European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 96, Issue 2 , Pages 183-186 , June 2001

The role of tamoxifen in the treatment of symptomatic uterine leiomyomata — a pilot study

Received 3 January 2000 ,Revised 29 June 2000 ,Accepted 28 July 2000.

References 

  1. Creasman WT. Disorders of uterine corpus. In: Scott JR, Disaia PJ, Hammond CB, Spellacy WN, editors. J.B. Danfort’s obstetric and gynecology. Philadelphia: Lippincott company, 1994. p. 925–55.
  2. Nelson WO. Endometrial and myometrial changes, including fibromatous nodules, induced in the uterus of the guinea pig by the prolonged administration of estrogenic hormone. Anat. Rec. 1937;68:99–102
  3. Lipschütz A. Experimental fibroids and the antifibromatogenic action of steroid hormones. JAMA. 1942;120:172–175
  4. John AH, Martin R. Growth of leiomyoma with estrogen progestogen therapy. J. Reprod. Med. 1971;6:56–58
  5. Sadan O, van Iddekinge B, van Gelderen CJ, Savage N, Becker PJ, van der Walt LA, et al. Oestrogen and progesterone receptor concentrations in leiomyoma and normal myometrium. Ann. Clin. Biochem. 1987;24:263–267
  6. Pickergill A. GnRH agonists and add-back therapy: is there a perfect combination?. Br. J. Obstet. Gynaecol. 1998;105:475–485
  7. Fuchs Young R, Howe S, Hale L, Miles R, Walker C. Inhibition of estrogen stimulated growth of uterine leiomyoma by selective estrogen receptor modulators. Mol. Carcinog. 1996;17:151–159
  8. Howe SR, Gottardis MM, Everitt JI, Walker C. Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo. Endocrinology. 1995;136:4996–5003
  9. Howe SR, Pass HI, Ethier SP, Matthews WJ, Walker C. Presence of an insulin like growth factor I autocrine loop predicts uterine fibroid responsiveness to tamoxifen. Cancer Res. 1996;56:4049–4055
  10. Lumsden MA, West CP, Baird DT. Tamoxifen prolongs luteal phase in premenopausal women but has no effect on the size of uterine fibroids. Clin. Endocrinol. Oxf. 1989;31:335–343
  11. Dilts PV, Hopkins MP, Chang AE, Cody RL. Rapid growth of leiomyoma in Patiens receiving tamoxifen. Am. J. Obstet. Gynecol. 1992;166:167–168
  12. Shushan A, Peretz T, Uziely B, Lewin A, Mor Yosef S. Ovarian cysts in premenopausal and postmenopausal tamoxifen treated women with breast cancer receiving tamoxifen. Am. J. Obstet. Gynecol. 1996;174:141–144
  13. Shulman A, Cohen I, Altaras MM, Maymon R, Ben Nun I, Tepper R, et al. Ovarian cyst formation in two pre-menopausal patients treated with tamoxifen for breast cancer. Hum. Reprod. 1994;9:1427–1429
  14. Stearns V, Gelmann EP. Does tamoxifen cause cancer in humans?. J. Clin. Oncol. 1998;16:779–792
  15. Burroughs KD, Kiguchi K, Howe SR, Fuchs Young R, Trono D, Barrett JC, et al. Regulation of apoptosis in uterine leiomyomata. Endocrinology. 1997;138:3056–3064

PII: S0301-2115(00)00468-1

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 96, Issue 2 , Pages 183-186 , June 2001

Article Tools

* Image Usage & Resolution