European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 105, Issue 2 , Pages 166-169 , 15 November 2002

IUD use and the risk of endometrial cancer

  • Abraham Benshushan

      Affiliations

    • Department of Obstetrics and Gynecology, Hebrew University, Hadassah Ein-Kerem Medical Center, Jerusalem, Israel
    • Corresponding Author InformationCorresponding author. Present address: Department of Obstetrics and Gynecology, St. Louis University, 6420 Clayton Rd. Suite 290, St. Louis, MO 63117-1811, USA. Tel.: +1-314-781-4772/514-8713 (R); fax: +1-314-781-1330.
    • ,
  • Ora Paltiel

      Affiliations

    • Department of Social Medicine, Hebrew University, Hadassah Ein-Kerem Medical Center, Jerusalem, Israel
    • ,
  • Nathan Rojansky

      Affiliations

    • Department of Obstetrics and Gynecology, Hebrew University, Hadassah Ein-Kerem Medical Center, Jerusalem, Israel
    • ,
  • Amnon Brzezinski

      Affiliations

    • Department of Obstetrics and Gynecology, Hebrew University, Hadassah Ein-Kerem Medical Center, Jerusalem, Israel
    • ,
  • Neri Laufer

      Affiliations

    • Department of Obstetrics and Gynecology, Hebrew University, Hadassah Ein-Kerem Medical Center, Jerusalem, Israel

Received 9 March 2002 ,Accepted 17 April 2002.

References 

  1. Alvarez F, Brache V, Fernandez E, et al.  New insights on the mode of action of intrauterine contraceptive devices in women. Fertil. Steril. 1988;49:768–773
  2. Ortiz ME, Croxatto HB. The mode of action of IUDs. Contraception. 1987;36:37–53
  3. Tursi A, Mastrorilli A, Ribatti D, Loiudice L, Contino R, Claudatus L. Possible role of mast cells in the mechanism of action of intra-uterine contraceptive devices. Am. J. Obstet. Gynecol. 1984;148:1064–1066
  4. El-Badrawi HH, Haffez ESE, Barnhart NI, Fayad M, Shafeek A. Ultrastructural changes in the human endometrium with copper and non-medicated IUDs in utero. Fertil. Steril. 1981;36:41–49
  5. Gonzalez-Angulo A, Aznar-Ramos R, Feria-Valesco F. Ultrastructural changes found in endometrium of women using Lippes intra-uterine devices. J. Reprod. Med. 1973;10:44–51
  6. Umapathysivam K, Jones WR. Effects of contraceptive agents on the biochemical and protein composition of human endometrium. Contraception. 1980;22:425–440
  7. Kontula K, Janne O, Luukkainen T, Vihko R. Progesterone binding protein in human myometrium, influence of metal ions on binding. J. Clin. Endocrinol. Metab. 1974;38:500–503
  8. Tamaya T, Nakata Y, Ohno Y, Nioka S, Furuta N, Okada H. The mechanism of action of copper intra-uterine device. Fertil. Steril. 1976;27:767–772
  9. Benshushan A, Paltiel O, Brzezinski A, Tanos V, Barchana A, Shoshani O, et al.  Ovulation induction and risk of endometrial cancer: a pilot study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2001;98:53–57
  10. Hartge P, Brinton LA, Rosenthal JF, Cahil JI, Hoover RN, Waksberg J. Random digit dialing in selecting a population-based control group. Am. J. Epidemiol. 1984;120:825–833
  11. Castellsague X, Thompson D, Dubrow R. Intra-uterine device use and the risk of endometrial cancer. Int. J. Cancer. 1993;54:911–916
  12. Parazzini F, La Vecchia C, Moroni S. Intrauterine device use and the risk of endometrial cancer. Br. J. Cancer. 1994;70:672–673
  13. Sturgeon SR, Brinton LA, Berman ML, et al.  Intrauterine device use and endometrial cancer risk. Int. J. Epidemiol. 1997;26:496–500
  14. Hill Da, Weiss NS, Voigt LF, Beresford SA. Endometrial cancer in relation to intra-uterine device use. Int. J. Cancer. 1997;70:278–281
  15. Rosenblatt KA, Thomas DB. Intrauterine devices and endometrial cancer. The WHO collaborative study of neoplasia and steroid contraceptives. Contraception. 1996;54:329–332

PII: S0301-2115(02)00153-7

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 105, Issue 2 , Pages 166-169 , 15 November 2002

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