European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 105, Issue 2 , Pages 120-123 , 15 November 2002

Mucin-like carcinoma-associated antigen in paired serum and breast milk samples of lactating mothers and sera of their neonates in the early postpartum period

  • Galini Giannaki

      Affiliations

    • Neonatal Unit of the Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, University of Athens, Athens, Greece
    • ,
  • Angeliki Sarandakou

      Affiliations

    • Hormone Laboratory of the Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, University of Athens, 76 Vas. Sophias Avenue, GR-115 28 Athens, Greece
    • ,
  • Demetrios Rizos

      Affiliations

    • Hormone Laboratory of the Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, University of Athens, 76 Vas. Sophias Avenue, GR-115 28 Athens, Greece
    • ,
  • Kyriaki Xyni

      Affiliations

    • Neonatal Unit of the Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, University of Athens, Athens, Greece
    • ,
  • Efthimia Protonotariou

      Affiliations

    • Hormone Laboratory of the Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, University of Athens, 76 Vas. Sophias Avenue, GR-115 28 Athens, Greece
    • ,
  • Iphigenia Phocas

      Affiliations

    • Hormone Laboratory of the Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, University of Athens, 76 Vas. Sophias Avenue, GR-115 28 Athens, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30-1-722-9854; fax: +30-1-728-6229.

Received 21 February 2002 ,Accepted 18 April 2002.

References 

  1. Bieglmayer C, Szepesi T, Neunteufel W. Follow-up of metastatic breast cancer patients with a mucin-like carcinoma-associated antigen (MCA): comparison to CA 15.3 and CEA. Cancer Lett. 1988;42:199–206
  2. Stähli C, Takacs B, Miggiano V, Stachelin T, Carman H. Monoclonal antibodies against antigens on breast cancer cells. Experientia. 1985;41:1377–1384
  3. Stähli C, Caravatti M, Aeschbacher M, Kociba C, Takacs B, Carman H. A mucinous carcinoma-associated antigen (MCA) defined by three monoclonal antibodies against different epitopes. Cancer Res. 1988;413:3–10
  4. Sekine H, Ohno T, Kufe D. Purification and characterisation of a high molecular weight glycoprotein detectable in human milk and breast carcinomas. J. Immunol. 1985;135:3610–3615
  5. Bieglmayer C, Szepesi T, Kopp B, et al.  CA 15.3, MCA, CAM 26, CAM 29 are members of a polymorphic family of mucin-like glycoproteins. Tumor Biol. 1991;12:138–148
  6. Bieglmayer C, Szepesi T, Neunteufel W, Nowotny C. MCA, a monoclonal antibody-defined breast-tumor-associated antigen and its relation to CA 15.3. Tumor Biol. 1989;10:232–242
  7. Iakubovskaia RI, Kazachkina NI, Karnakova TA, et al.  Study of the integral antigen of the membranes of fatty globules of human milk. Eksp. Onkol. 1990;12(4):61–65
  8. Zenklusen HR, Stähli C, Gudat F, von Overbeck J, Rolink J, Heitz PU. The immunohistochemical reactivity of a new anti-epithelial monoclonal antibody (Mab b-12) against breast carcinoma and other normal and neoplastic human tissues. Virchows Arch. A Pathol. Anat. 1988;413:3–10
  9. Sarandakou A, Rizos D, Botsis D, et al.  Mucin-like carcinoma-associated antigen (MCA) during normal pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol. 2001;96:51–54
  10. Puetz I, Lang G, Winkler M, Rath W. Serum konzentrationen des tumormarker MCA in verlauf der schwangerschaft (serum concentrations of the MCA tumor marker during pregnancy). Zentrabl Gynäkol. 1996;118(7):409–411
  11. Agrawal B, Reddish MA, Krants MJ, Longenecker BM. Does pregnancy immunize against breast cancer?. Cancer Res. 1995;55(11):2257–2261
  12. Botello F, Clark DA. How might pregnancy immunize against breast cancer?. Am. J. Reprod. Immunol. 1998;39(4):279–283

PII: S0301-2115(02)00157-4

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 105, Issue 2 , Pages 120-123 , 15 November 2002

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