European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 105, Issue 2 , Pages 132-135 , 15 November 2002

Multidrug resistance 3 gene mutation 1712delT and estrogen receptor α gene polymorphisms in Finnish women with obstetric cholestasis

  • Marja-Liisa Eloranta

      Affiliations

    • Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    • ,
  • Jaana T.M Heiskanen

      Affiliations

    • Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    • ,
  • Mikko J Hiltunen

      Affiliations

    • Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland
    • Chromosome and DNA Laboratory of the Division of Diagnostic Services, Kuopio University Hospital, 70211 Kuopio, Finland
    • ,
  • Arto J Mannermaa

      Affiliations

    • Chromosome and DNA Laboratory of the Division of Diagnostic Services, Kuopio University Hospital, 70211 Kuopio, Finland
    • ,
  • Kari R.A Punnonen

      Affiliations

    • Department of Clinical Chemistry, Kuopio University Hospital, 70211 Kuopio, Finland
    • ,
  • Seppo T Heinonen

      Affiliations

    • Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    • Corresponding Author InformationCorresponding author. Tel.: +358-17-172-325; fax: +358-17-172-486.

Received 6 May 2001 ,Revised 25 July 2001 ,Accepted 4 April 2002.

References 

  1. Berg B, Helm G, Petersohn L, Tryrding N. Cholestasis of pregnancy: clinical and laboratory studies. Acta Obstet. Gynaecol. Scand. 1986;65:107–113
  2. Heinonen S, Kirkinen P. Pregnancy outcome with intrahepatic cholestasis. Obstet. Gynaecol. 1999;94:189–193
  3. Alsulyman OM, Ouzounian JG, Ames-Castro M, Goodwin TM. Intrahepatic cholestasis of pregnancy: perinatal outcome associated with expectant management. Am. J. Obstet. Gynaecol. 1996;175:957–960
  4. Fisk NM, Sotrey GN. Fetal outcome in obstetric cholestasis. Br. J. Obstet. Gynaecol. 1988;95:1137–1143
  5. Rioseco AJ, Ivankovic MB, Manzur A, Hamed F, Kato SR, Parer JT, et al.  Intrahepatic cholestasis of pregnancy: a retrospective case–control study of perinatal outcome. Am. J. Obstet. Gynaecol. 1994;170:890–895
  6. Hirvioja ML, Tuimala R, Vuori J. The treatment of intrahepatic cholestasis of pregnancy by dexamethasone. Br. J. Obstet. Gynaecol. 1992;99:109–111
  7. Palma J, Reyes H, Ribalta J, et al.  Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy. Hepatology. 1992;15:1043–1047
  8. Hirvioja ML, Kivinen S. Inheritance of intrahepatic cholestasis of pregnancy in one kindred. Clin. Genet. 1993;43:315–317
  9. Holzbach RT, Sivak DA, Braun WE. Familial recurrent intrahepatic cholestasis of pregnancy, a genetic study providing evidence for transmission of a sex-limited, dominant trait. Gastroenterology. 1983;85:175–179
  10. Reyes H, Simon FR. Intrahepatic cholestasis of pregnancy: an estrogen-related disease. Semin. Liver Dis. 1993;13:289–301
  11. Jacquemin E, Cresteil D, Manouvrier S, Boute O, Hadchouel M. Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy. Lancet. 1999;353:210–211
  12. Tyni T, Ekholm E, Pihko H. Pregnancy complications are frequent in long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. Am. J. Obstet. Gynaecol. 1998;178:603–608
  13. Cohen C, Lawson D, DeRose PB. Sex and androgenic steroid receptor expression in hepatic adenomas. Hum. Pathol. 1998;29:1428–1432
  14. Yaich L, Dupont WD, Cavener DR, Parl FF. Analysis of PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood. Cancer Res. 1992;52:77–83
  15. Vandenplas S, Grobler-Rabie A, Brebner K. Blot hybridization of genomic DNA. J. Med. Genet. 1984;21:164–172
  16. Mattila KM, Axelman K, Rinne JO, Blomberg M, Lehtimaki T, Laippala P, et al.  Interaction between estrogen receptor 1 and the epsilon4 allele of apolipoprotein E increases the risk of familial Alzheimer’s disease in women. Neurosci. Lett. 2000;17:45–48
  17. Salmen T, Heikkinen AM, Mahonen A, Kroger H, Komulainen M, Saarikoski S, et al.  Early postmenopausal bone loss is associated with PvuII estrogen receptor gene polymorphism in Finnish women: effect of hormone replacement therapy. J. Bone Miner. Res. 2000;15:315–321
  18. Peltonen L, Jalanko A, Varilo T. Molecular genetics of the Finnish disease heritage. Hum. Mol. Genet. 1999;8:1913–1923

PII: S0301-2115(02)00160-4

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 105, Issue 2 , Pages 132-135 , 15 November 2002

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