European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 105, Issue 2 , Pages 136-142 , 15 November 2002

Structural, functional and circulatory placental changes associated with impaired glucose metabolism

  • Pia Saldeen

      Affiliations

    • Department of Obstetrics and Gynecology, Malmö University Hospital, Lund University, Malmö, Sweden
    • Corresponding Author InformationCorresponding author. IVF Unit, Curakliniken, P.O. Box 20037, S-20074 Malmö, Sweden. Tel.: +46-40-987055 (O), 511550 (R); fax: +46-40-987055 (O), 511550 (R).
    • ,
  • Per Olofsson

      Affiliations

    • Department of Obstetrics and Gynecology, Malmö University Hospital, Lund University, Malmö, Sweden
    • ,
  • Ricardo N Laurini

      Affiliations

    • Department of Obstetrics and Gynecology, San Joao University Hospital, Porto, Portugal

Received 16 November 2000 ,Revised 26 January 2002 ,Accepted 2 April 2002.

References 

  1. Persson B, Gentz J, Lunell NO. Diabetes in pregnancy. In: Scarpelli EM, Cosmi EV, editors. Reviews in perinatal Medicine. New York: Raven, 1978. p. 1–55.
  2. Hauguel de Mouzon S, Louizeau M, Girard J. Functional alterations of type I insulin-like growth factor receptor in placenta of diabetic rats. Biochem. J. 1992;288(1):273–279
  3. Teasdale F. Histomorphometry of the placenta of the diabetic woman: class A diabetes mellitus. Placenta. 1981;2:241–522
  4. Dadak C, Kefalides A, Sinzinger H, Weber G. Reduced umbilical artery prostacyclin formation in complicated pregnancies. Am. J. Obstet. Gynecol. 1982;144:792–795
  5. Stuart MJ, Sunderji SG, Walenga RW, Setty BNY. Abnormalities in vascular arachidonic acid metabolism in the infant of the diabetic mother. Br. Med. J. 1985;290:1700–1702
  6. Figueroa R, Omar HA, Tejani N, Wolin MS. Gestational diabetes alters human placental vascular responses to changes in oxygen tension. Am. J. Obstet. Gynecol. 1993;168:1616–1622
  7. Wilkes BM, Mento PF, Hollander AM. Reduced thromboxane receptor affinity and vascular responses in placentae from diabetic pregnancies. Placenta. 1994;15:845–855
  8. Kuhn DC, Botti JJ, Cherouny PH, Demers LM. Eicosanoid production and transfer in the placenta of the diabetic pregnancy. Prostaglandins. 1990;40:205–215
  9. Walters WAW, Boura ALA. Regulation of fetal vascular tone in the human placenta. Reprod. Fertil. Dev. 1991;3:475–481
  10. Saldeen P, Olofsson P, Parhar RS, Al-Sedairy S. Prostanoid production in umbilical vessels and its relation to glucose tolerance and umbilical artery flow resistance. Eur. J. Obstet. Gynecol. Reprod. Biol. 1996;68:35–41
  11. Saldeen P, Olofsson P, Parhar RS, Al-Sedairy S. Prostanoid production in the umbilicoplacental arterial tree relative to impaired glucose tolerance. Early Hum. Dev. 1998;50:175–183
  12. Wang J, Zhen E, Guo Z, Lu Y. Effect of hyperlipidemic serum on lipid peroxidation, synthesis of prostacyclin and thromboxane by cultured endothelial cells: protective effect of antioxidants. Free Radical Biol. Med. 1989;7:243–249
  13. Olofsson P, Laurini RN, Lingman G, Marsál K. Feto-maternal circulatory changes related to placental morphology in diabetes mellitus. Echocardiography. 1990;7:613–618
  14. World Health Organization Expert Committee on Diabetes Mellitus. Technical Report Series No. 727, Geneva, 1985. p. 9–17.
  15. Gudmundsson S, Marsál K. Umbilical artery and uteroplacental blood flow velocity waveforms in normal pregnancy: a cross-sectional study. Acta Obstet. Gynecol. Scand. 1988;67:347–354
  16. Al Frayh AS, Haque KN. Intrauterine and fetal growth standards for Saudi Arabia and the Gulf region. Saudi Med. J. 1993;14:133–137
  17. Saldeen P, Esquivel CO, Björck C-G, Berqvist D, Saldeen T. Thromboxane production in umbilical vein grafts. Thromb. Res. 1984;33:259–267
  18. Laurini RN, Visser GHA, van Ballegooie E, Schoots CJF. Morphological findings in placentae of insulin-dependent diabetic patients treated with continuous subcutaneous insulin infusion (CSII). Placenta. 1987;8:153–165
  19. Benirschke K, Kaufmann P. Maternal diseases complicating pregnancy: diabetes, tumors, preeclampsia, lupus anticoagulant. In: Pathology of the human placenta. 3rd ed. New York: Springer, 1995. p. 476–536.
  20. Yagel S, Anteby EY, Shen O, Cohen SM, Friedman Z, Achiron R. Placental blood flow measured by simultaneous multigate spectral Doppler imaging in pregnancies complicated by placental vascular abnormalities. Ultrasound Obstet. Gynecol. 1999;14:262–266
  21. Gudmundsson S, Marsal J, Dubiel M, Maly P, Marsal K, Laurini R. Power Doppler, X-ray contrast angiography and morphological imaging of the human placenta. Prenatal Neonatal Med. 2000;5:27–34
  22. Montenegro N, Laurini R, Brandao O, Nogueira R, Matias A, Santos F, et al.  Placental findings in fetuses with absent or reversed end-diastolic flow in the umbilical artery (ARED flow): a reappraisal. J. Matern. Fetal. Invest. 1997;7:175–179
  23. Saldeen P, Olofsson P, Marsál K. Lack of association between Doppler velocimetry and synthesis of prostacyclin and thromboxane in umbilical cord vessels from growth retarded fetuses. Acta Obstet. Gynecol. Scand. 1995;74:103–108
  24. Sinclair AJ. Free radical mechanisms and vascular complications of diabetes mellitus. Diabetes Rev. 1993;2:7–10
  25. Force T, Milani R, Hibberd P, Lorenz R, Uedelhoven W, Leaf A, et al.  Aspirin-induced decline in prostacyclin production in patients with coronary artery disease is due to decreased endoperoxide shift: analysis of effects of a combination of aspirin and n − 3 fatty acids on the eicosanoid profile. Circulation. 1991;84:2286–2293
  26. Gryglewski RJ, Botting RM, Vane JR, Prostacyclin: from discovery to clinical application. In: Rubanyi GM, editor. Cardiovascular significance of endothelium-derived vasoactive factors. Mount Kisco: Futura Publishers, 1991. p. 3–28.
  27. Takenshi A, Benirschke K. Renal vein thrombosis of the newborn and its relation to maternal diabetes. Biol. Neonate. 1961;3:237–240

PII: S0301-2115(02)00161-6

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 105, Issue 2 , Pages 136-142 , 15 November 2002

Article Tools

* Image Usage & Resolution