European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 121, Issue 2 , Pages 195-201 , 1 August 2005

Is endometrial apoptosis evidence of endometrial aging in unexplained infertility? a preliminary report

  • Cemal Tamer Erel

      Affiliations

    • Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
    • Corresponding Author InformationCorresponding author. Present address: Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Kasaneler Sk., Nigarhanim Apt. No. 28/11 Erenkoy, 81070 Istanbul, Turkey. Tel.: +90 212 414 30 00/21448 (Office), +90 532 2946022 (Mobile); fax: +90 212 2341714.
    • ,
  • Yavuz Aydin

      Affiliations

    • Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
    • ,
  • Semih Kaleli

      Affiliations

    • Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
    • ,
  • Sennur Ilvan

      Affiliations

    • Department of Pathology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
    • ,
  • Levent Mehmet Senturk

      Affiliations

    • Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey

Received 27 June 2004 ,Revised 19 January 2005 ,Accepted 21 January 2005.

References 

  1. Raff MC. Social controls on cell survival and cell death. Nature. 1992;356:397–400
  2. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239–257
  3. Arends MJ, Morris RG, Wyllie AH. Apoptosis: the role of endonuclease. Am J Pathol. 1990;136:593–608
  4. Bortner CD, Odernburg NBE, Crdlowski JA. The role of fragmentation in apoptosis. Trends Cell Biol. 1995;5:21–28
  5. Dominguez F, Remohr J, Pellicer A, Simon C. Human endometrial receptivity: a genomic approach. RBO. 2003;6:332–338
  6. Kokawa K, Shikone T, Nakano R. Apoptosis in the human uterine endometrium during the menstrual cycle. J Clin Endocrinol Metab. 1996;81:4144–4147
  7. Shikone T, Kokawa K, Yamota M, Nakano R. Apoptosis of human ovary and uterine endometrium during the menstrual cycle. Horm Res. 1997;48(Suppl 3):27–34
  8. Von Rango U, Classen-Linke I, Krusche CA, Beier HM. The receptive endometrium is characterized by apoptosis in the glands. Hum Reprod. 1998;13:3177–3189
  9. Galan A, Herrer R, Remohi J, Pellicer A, Simon C. Embryonic regulation of endometrial epithelial apoptosis during human implantation. Hum Reprod. 2000;15(Suppl 6):74–80
  10. Garcia-Velasco JA, Arici A. Apoptosis and the pathogenesis of endometriosis. Semin Reprod Med. 2003;21:165–172
  11. Maliqueo M, Clementi M, Gabler F, et al. Expression of steroid receptors and proteins related to apoptosis in endometria of women with polycystic ovary syndrome. Fertil Steril. 2003;80(Suppl 2):812–819
  12. Tabibzadeh S. Molecular control of the implantation window. Hum Reprod Update. 1998;4:465–471
  13. Yasuda M, Umamura S, Osamura RY, Kenja T. Apoptotic cells in the human endometrium and placental villi; pitfalls in applying the TUNEL method. Arch Histol Cytol. 1995;58:185–190
  14. Umamura S, Yasuda M, Osamura RY, Kawarada Y, Sugiyama T. Enhancement of TdT mediated dUTTP-biotin nick end labeling method using mung bean nuclease, a single stranded DNA digestion enzyme. J Histochem Cytochem. 1996;44:125–132
  15. Kligman I, Rosenwaks Z. Differentiating clinical profiles: predicting good responders, poor responders, and hyperresponders. Fertil Steril. 2001;76:1185–1190
  16. Sadraie SH, Saito H, Kaneko T, Saito T, Hiroi M. Effects of aging on ovarian fecundity in terms of the incidence of apoptotic granulosa cells. J Assist Reprod Genet. 2000;17:168–173
  17. Wu J, Zhang L, Wang X. Maturation and apoptosis of human oocytes in vitro are age-related. Fertil Steril. 2000;74:1137–1141
  18. Miller MM, Teng CJ, Mitmaker B, Wang E. Characterization of the tissue regression process in the uterus of older mice as apoptotic by the presence of Tp30, an isoform of terminin. Eur J Histochem. 1995;39:91–100
  19. Noyes N, Hampton BS, Berkeley A, Licciardi F, Grifo J, Krey L. Factors useful in predicting the success of oocyte donation: a 3-year retrospective analysis. Fertil Steril. 2001;76:92–97
  20. Mirkin S, Gimeno TG, Bovea C, Stadtmauer L, Gibbons WE, Oehninger S. Factors associated with an optimal pregnancy outcome in an oocyte donation program. J Assist Reprod Genet. 2003;20:400–408
  21. Toner JP, Grainger DA, Frazier LM. Clinical outcomes among recipients of donated eggs: an analysis of the U.S. national experienced, 1996–1998. Fertil Steril. 2002;78:1038–1045
  22. Yaron Y, Botchan A, Amit A, Kogosowski A, Yovel I, Lessing JB. Endometrial receptivity: the age-related decline in pregnancy rates and the effect of ovarian function. Fertil Steril. 1993;60:314–318
  23. Sauer MV, Cohen MA. Egg and embryo donation. In:  Gardner DK,  Weissman A,  Howles CM,  Shoham Z editor. The Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspective. 2nd ed.. London: Taylor and Francis Group; 2004;p. 843
  24. Garcia-Velasco JA, Isaza V, Caligara C, Pellicer A, Remohi J, Simon C. Factors that determine discordant outcome from shared oocytes. Fertil Steril. 2003;80:54–60
  25. Cano F, Simon C, Remohi J, Pellicer A. Effect of aging on the female reproductive system: evidence for a role of uterine senescence in the decline in female fecundity. Fertil Steril. 1995;64:584–589
  26. Dahmoun M, Boman K, Cajander S, Westin P, Backstrom T. Apoptosis, proliferation, and sex hormone receptors in superficial parts of human endometrium at the end of the secretory phase. J Clin Endocrinol Metab. 1999;84:1737–1743
  27. Vaskivuo TE, Stenback F, Karhumaa P, Risteli J, Dunkel L, Tapanainen JS. Apoptosis and apoptosis-related proteins in human endometrium. Mol Cell Endocrinol. 2000;165:75–83
  28. Giudice LC. Elucidating endometrial function in the post-genomic era. Hum Reprod Update. 2003;9:223–235
  29. Damario MA, Lesnick TG, Lessey BA, et al. Endometrial markers of uterine receptivity utilizing the donor oocyte model. Hum Reprod. 2001;16:1893–1899
  30. Ceydeli N, Kaleli S, Calay Z, Erel CT, Akbas F, Ertungealp E. Increased endometrial stromal cell vitronectin (ανβ3) expression in women with unexplained infertility. In: 18th Annual Meeting. European Society of Human Reproduction and Embryology, vol. O-226. Human Reproduction, 1–3 July, Vienna. 2002;p. 79
  31. Kowalski AA, Vale-Cruz DS, Simmen FA, Simmen RC. Uterine androgen receptors: roles in estrogen-mediated gene expression and DNA synthesis. Biol Reprod. 2004;[Epub ahead of print]
  32. Cermik D, Selam B, Taylor HS. Regulation of HOXA-10 expression by testosterone in vitro and in the endometrium of patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003;88:238–243
  33. Gerhard I, Bechthold E, Eggert-Kruse W, Heberling D, Runnebaum B. Value of endometrial biopsies and serum hormone determinations in women with infertility. Hum Reprod. 1990;5:906–914

PII: S0301-2115(05)00020-5

doi: 10.1016/j.ejogrb.2005.01.012

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 121, Issue 2 , Pages 195-201 , 1 August 2005

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