Sildenafil reduces postoperative adhesion formation in a rat uterine horn model

Abstract 

Objective

The purpose of this experimental study was to evaluate the effect of oral sildenafil on postoperative adhesion formation in rats.

Study design

Thirty-two Wistar Albino rats were subjected to standardized lesion by cauterization of the uterine horn and abrasion of the adjacent parietal peritoneum. They were randomized to receive sildenafil at a daily dose of 15mg/kg, 7.5mg/kg and 3.75mg/kg or placebo. Sildenafil was administered by gavage 1h before the operation and daily for 5 days after the procedure. The extent and severity of adhesions were assessed on the 14th postoperative day.

Result(s)

The severity but not extent of adhesions in rats given 15mg/kg sildenafil was significantly less when compared with the other groups (<0.001).

Conclusion

Sildenafil diminishes peritoneal adhesion formation in rat.

Keywords: Sildenafil, Phosphodiesterase, Adhesion, Rat, Peritoneum, Postoperative