European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 134, Issue 1 , Pages 44-50 , September 2007

Amnionitis with Ureaplasma urealyticum or other microbes leads to increased morbidity and prolonged hospitalization in very low birth weight infants

  • Lieselotte Kirchner

      Affiliations

    • Department of Neonatology and Intensive Care, University Hospital of Pediatrics, Waehringer Guertel 18-20, 1090 Vienna, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 1 40 400 3232; fax: +43 1 40 400 3165.
  • ,
  • Hanns Helmer

      Affiliations

    • Division of Gynecology and Obstetrics, University Hospital of Gynecology, Vienna, Austria
  • ,
  • Georg Heinze

      Affiliations

    • Core Unit for Medical Statistics and Informatics, Medical University of Vienna, Vienna, Austria
  • ,
  • Martin Wald

      Affiliations

    • Department of Neonatology and Intensive Care, University Hospital of Pediatrics, Waehringer Guertel 18-20, 1090 Vienna, Austria
  • ,
  • Mathias Brunbauer

      Affiliations

    • Division of Gynecology and Obstetrics, University Hospital of Gynecology, Vienna, Austria
  • ,
  • Manfred Weninger

      Affiliations

    • Department of Neonatology and Intensive Care, University Hospital of Pediatrics, Waehringer Guertel 18-20, 1090 Vienna, Austria
  • ,
  • Daniela Zaknun

      Affiliations

    • Department of Neonatology and Intensive Care, University Hospital of Pediatrics, Waehringer Guertel 18-20, 1090 Vienna, Austria

Received 10 August 2004 ,Revised 7 June 2006 ,Accepted 25 September 2006.

References 

  1. Berg TG, Philpot KL, Welsh MS, Sanger WG, Smith CV. Ureaplasma/Mycoplasma-infected amniotic fluid: pregnancy outcome in treated and nontreated patients. J Perinatol. 1999;19(4):275–277
  2. Eschenbach DA. Ureaplasma urealyticum and premature birth. Clin Infect Dis. 1993;17(Suppl. 1):100–106
  3. Gray DJ, Robinson HB, Malone J, Thomson RB. Adverse outcome in pregnancy following amniotic fluid isolation of Ureaplasma urealyticum. Prenat Diagn. 1992;12(2):111–117
  4. Yoon BH, Chang JW, Romero R. Isolation of Ureaplasma urealyticum from the amniotic cavity and adverse outcome in preterm labor. Obstet Gynecol. 1998;92(1):77–82
  5. Yoon BH, Romero R, Park JS, et al. Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol. 1998;179(5):1254–1260
  6. Yoon BH, Romero R, Lim JH, et al. The clinical significance of detecting Ureaplasma urealyticum by the polymerase chain reaction in the amniotic fluid of patients with preterm labor. Am J Obstet Gynecol. 2003;189(4):919–924
  7. Dusick AM. Medical outcomes in preterm infants. Sem Perinatol. 2001;21:164–167
  8. Palta M, Gabbert D, Weinstein MR, Peters ME. Multivariante assessment of traditional risk factors for chronic lung disease in very low birth weight neonates. J Pediatr. 1991;119:285–292
  9. Crouse DT, Odrezin GT, Cutter GR, et al. Radiographic changes associated with tracheal isolation of Ureaplasma urealyticum from neonates. Clin Infect Dis. 1993;17(Suppl. 1):122–130
  10. Groneck P, Goetze-Speer B, Speer CP. Inflammatory bronchopulmonary response of preterm infants with microbial colonisation of the airways at birth. Arch Dis Child Fetal Neonatal. 1996;74(1):F51–F55
  11. Hannaford K, Todd DA, Jeffery H, John E, Blyth K, Gilbert GL. Role of Ureaplasma urealyticum in lung disease of prematurity. Arch Dis Child Fetal Neonatal Ed. 1999;81(3):F162–F167
  12. Kotecha S, Hodge R, Schaber JA, Miralles R, Silverman M, Grant WD. Pulmonary Ureaplasma urealyticum is associated with the development of acute lung inflammation and chronic lung disease in preterm infants. Pediatr Res. 2004;55(1):61–68
  13. Ollikainen J, Heiskanen-Kosma T, Korppi M, Katila ML, Heinonen K. Clinical relevance of Ureaplasma urealyticum colonization in preterm infants. Acta Paediatr. 1998;87(10):1075–1078
  14. Pacifico L, Panero A, Roggini M, Rossi N, Bucci G, Chiesa C. Ureaplasma urealyticum and pulmonary outcome in a neonatal intensive care population. Pediatr Infect Dis J. 1997;16(6):579–586
  15. Wang EE, Ohlsson A, Kellner JD. Association of Ureaplasma urealyticum colonization with chronic lung disease of prematurity: results of a metaanalysis. J Pediatr. 1995;127(4):640–644
  16. Ghezzi F, Gomez R, Romero R, et al. Elevated interleukin-8 concentrations in amniotic fluid of mothers whose neonates subsequently develop bronchopulmonary dysplasia. Eur J Obstet Gynecol Reprod Biol. 1998;78(1):5–10
  17. Lyon A. Chronic lung disease of prematurity. The role of intra-uterine infection. Eur J Peditr. 2000;159(11):798–802
  18. Yoon BH, Romero R, Moon JB, et al. Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 2001;185(5):1130–1136
  19. Vermont Oxford Network Database. Manual of operations for infants born in 2002.
  20. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Ass. 1958;53:457–581
  21. Horowitz S, Mazor M, Romero R, Horowitz J, Glezerman M. Infection of the amniotic cavity with Ureaplasma urealyticum in the midtrimester of pregnancy. J Reprod Med. 1995;40(5):375–379
  22. Gravett MG, Hummel D, Eschenbach DA, Holmes KK. Preterm labor associated with subclinical amniotic fluid infection and with bacterial vaginosis. Obstet Gynecol. 1986;67(2):229–237
  23. Berger A, Witt A, Haiden N, Kretzer V, Heinze G, Kohlhauser C. Microbial invasion of the amniotic cavity at birth is associated with adverse short-term outcome of preterm infants. J Perinat Med. 2003;31:115–121
  24. De Dooy JJ, Mahieu LM, Van Bever HP. The role of imflammation in the development of chronic lung disease in neonates. Eur J Pediatr. 2001;160(8):457–463
  25. Ollikainen J. Perinatal Ureaplasma urealyticum infection increases the need for hospital treatment during the first year of life in preterm infants. Pediatr Pulmonol. 2000;30(5):402–405
  26. Mazor M, Horowitz S, Meril T, Bar-Am I. Eradication of Ureaplasma urealyticum from amniotic fluid. Isr J Med Sci. 1992;28(5):296–298
  27. Mazor M, Chaim W, Horowitz S, Leiberman JG, Glezerman M. Successful treatment of preterm labour by eradication of Ureaplasma urealyticum with erythromycin. Arch Gynecol Obstet. 1993;253(4):215–218
  28. Romero R, Hagay Z, Nores J, Sepulveda W, Mazor M. Eradication of Ureaplasma urealyticum from the amniotic fluid with transplacental antibiotic treatment. Am J Obstet Gynecol. 1992;166(2):618–620
  29. Kenyon S, Boulvain M, Neilson J. Antibiotics for preterm rupture of membranes. Cochrane Database Syst Rev. 2003;(2):CD001058
  30. Waites KB, Crouse DT, Cassell GH. Therapeutic considerations for Ureaplasma urealyticum infections in neonates. Clin Infect Dis. 1993;17(Suppl. 1):208–214
  31. Waites KB, Sims PJ, Crouse DT, et al. Serum concentrations of erythromycin after intravenous infusion in preterm neonates treated for Ureaplasma urealyticum infection. Pediatr Infect Dis J. 1994;13(4):287–293
  32. Klein LL, Gibbs RS. Use of microbial cultures and antibiotics in the prevention of infection-associated preterm birth. Am J Obstet Gynecol. 2004;190(June (6)):1493–1502
  33. Lyon AJ, McColm J, Middlemist L, Fergusson S, Mclntosh N, Ross PW. Randomised trial of erythromycin on the development of chronic lung disease in preterm infants. Arch Dis Child Fetal Neonatal Ed. 1998;78(1):F10–F14
  34. Heikkinen T, Laine K, Neuvonen PJ, Ekblad U. The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. Br J Obstet Gynaecol. 2000;107:770–775

PII: S0301-2115(06)00516-1

doi: 10.1016/j.ejogrb.2006.09.013

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 134, Issue 1 , Pages 44-50 , September 2007