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European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 136, Issue 1
, Pages 29-33
, January 2008
Determination of metformin transfer across the human placenta using a dually perfused ex vivo placental cotyledon model
References
- . Metformin in management of pregnant insulin-independent diabetics. Diabetologia. 1979;16:241–245
- . Effects of in-utero exposure to oral hypoglycaemic drugs. Lancet. 1991;338:866–869
- . Oral hypoglycaemic agents in 118 diabetic pregnancies. Diabet Med. 2000;17:507–511
- . The safety of oral hypoglycemic agents in the first trimester of pregnancy: a meta-analysis. Can J Clin Pharmacol. 2003;10:179–183
- . Metformin vs. insulin in A2 diabetics; a randomized clinical trial. Am J Obstet Gynecol. 2005;191:17
- . Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome. Metabolism. 1999;48:511–519
- . Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy. Hum Reprod. 2004;19:510–521
- . Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, d-chiro-inositol) for polycystic ovary syndrome. Cochrane Database Syst Rev. 2003;CD003053
- . Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril. 2001;75:46–52
- . Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab. 2002;87:524–529
- . Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome. Diabet Med. 2004;21:829–836
- . Metformin and gestational diabetes. Curr Diab Rep. 2003;3:303–312
- . Insignificant transfer of glyburide occurs across the human placenta. Am J Obstet Gynecol. 1991;165:807–812
- . Comparative placental transport of oral hypoglycemic agents in humans: a model of human placental drug transfer. Am J Obstet Gynecol. 1994;171:653–660
- . A comparison of glyburide and insulin in women with gestational diabetes mellitus. N Engl J Med. 2000;343:1134–1138
- . Comparison of glyburide and insulin for the management of gestational diabetes in a large managed care organization. Am J Obstet Gynecol. 2005;193:118–124
- . Metformin in obstetric and gynecologic practice: a review. Obstet Gynecol Surv. 2004;59:118–127
- . Should we continue or stop insulin sensitizing drugs during pregnancy?. Curr Opin Obstet Gynecol. 2004;16:245–250
- . Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. Mol Pharmacol. 2003;63:844–848
- Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005;20:379–386
- . Metformin transport by renal basolateral organic cation transporter hOCT2. Pharm Res. 2005;22:255–259
- . Dual in vitro perfusion of an isolated lobe of human placenta: method and instrumentation. Contrib Gynecol Obstet. 1985;13:40–47
- . Determination of metformin in plasma using a new ion pair solid phase extraction technique and ion pair liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;798:203–209
- . Transfer across the perfused human placenta of antipyrine, sodium and leucine. Am J Obstet Gynecol. 1972;114:822–828
- . Models for placental transfer studies of drugs. Clin Pharmacokinet. 1995;28:161–180
- Placental transfer of SR49059 in the human dually perfused cotyledon in vitro. Placenta. 2001;22:870–875
- . Placental drug transporters. Curr Drug Metab. 2004;5:125–131
- . Placental passage of metformin in women with polycystic ovary syndrome. Fertil Steril. 2005;83:1575–1578
PII: S0301-2115(07)00080-2
doi: 10.1016/j.ejogrb.2007.01.013
© 2007 Elsevier Ireland Ltd. All rights reserved.
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European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 136, Issue 1
, Pages 29-33
, January 2008
