European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 136, Issue 2 , Pages 155-159 , February 2008

Enzyme linked immunosorbent assay (ELISA) as screening method for anti-paternal allo-antibodies in patients with recurrent pregnancy loss (RPL)

  • Nina Rogenhofer

      Affiliations

    • Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Ludwig-Maximilians-University, München Großhadern, Marchioninistrasse 15, D-81377 München, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 8970950; fax: +498970953844.
    • ,
  • Bettina Toth

      Affiliations

    • Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Ludwig-Maximilians-University, München Großhadern, Marchioninistrasse 15, D-81377 München, Germany
    • ,
  • Stephan Kiessig

      Affiliations

    • German Association for Humanplasma, Ludwigshafen, Germany
    • ,
  • Peter Hellstern

      Affiliations

    • Institute of Hemostaseology and Transfusion Medicine, Klinikum Ludwigshafen, Germany
    • ,
  • Uwe Taborski

      Affiliations

    • German Association for Humanplasma, Ludwigshafen, Germany
    • ,
  • Siegfried Scholz

      Affiliations

    • Laboratory for Immungenetics, Childrens Hospital, Ludwig-Maximilians-University, Munich, Germany
    • ,
  • Christian J. Thaler

      Affiliations

    • Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Ludwig-Maximilians-University, München Großhadern, Marchioninistrasse 15, D-81377 München, Germany
    • Tel.: +49 8970950; fax: +49 8970954588.

Received 10 February 2006 ,Revised 18 September 2006 ,Accepted 5 March 2007.

References 

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  11. McIntyre JA, Faulk WP. Recurrent spontaneous abortion in human pregnancy: results of immunogenetical, cellular and humoral studies. Am J Reprod Immunol Microbiol. 1983;4:165
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  14. Stein J, Blanck K, Löhrs B, Scholz S, Thaler CJ. In-vitro and in vivo effects of polyvalent immunoglobulins in patients with recurrent spontaneous abortion and antipaternal non-HLA antibodies. Geb Fra. 2000;60:251–256
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  19. Orgad S, Gazit E, Carp HJ. Shared HLA antigens in couples with 5 or more, compared to 3 or 4 consecutive recurrent miscarriages. Early Pregnancy. 2000;4(2):144–153
  20. Matsubayashi H, Maruyama T, Ozawa N, et al. Anti-paternal antibodies by flow cytometry in the management of alloimmunization on recurrent miscarriages. Am J Reprd Immunol. 2000;44(5):284–288
  21. Stephenson M, Wu V, Mackinnon M, Sadoway J, Keown P. Standardization of flow cytometric crossmatch (FCXM) for investigation of unexplained habitual abortion. Am J Reprod Immunol. 1995;33(1):1–9
  22. Maruyama T, Makino T, Sugi T, et al. Flow cytometric crossmatch and early pregnancy loss in women with a history of recurrent spontaneous abortions who underwent paternal leukocyte immunotherapy. Am J Obstet Gynecol. 1993;168(5):1528–1536
  23. Buchholz T, Lohse P, Rogenhofer N, Kosian E, Pihusch R, Thaler CJ. Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages. Hum Reprod. 2003;18(11):2473–2477
  24. Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295–306
  25. Rowe P, Comhaire F, Hargreave T, Mellows H. WHO manual for the standardized investigation and diagnosis of the infertile couple. World Health Organization. Cambridge University Press; 1993;

PII: S0301-2115(07)00128-5

doi: 10.1016/j.ejogrb.2007.03.002

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 136, Issue 2 , Pages 155-159 , February 2008

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