European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 138, Issue 2 , Pages 135-140 , June 2008

Comparing two dinoprostone agents for cervical ripening and induction of labor: A randomized trial

  • Anna Maria Marconi

      Affiliations

    • Department of Obstetrics & Gynecology, DMSD San Paolo, University of Milano, Via A. di Rudini’ 8, 20142 Milano, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 02 503 23064; fax: +39 02 936 50639.
  • ,
  • Patrizia Bozzetti

      Affiliations

    • Department of Obstetrics & Gynecology, DMSD San Paolo, University of Milano, Via A. di Rudini’ 8, 20142 Milano, Italy
  • ,
  • Alberto Morabito

      Affiliations

    • Department of Statistics, DMSD San Paolo, University of Milano, Via A. di Rudini’ 8, 20142 Milano, Italy
  • ,
  • Giorgio Pardi

      Affiliations

    • Department of Obstetrics & Gynecology, DMSD San Paolo, University of Milano, Via A. di Rudini’ 8, 20142 Milano, Italy

Received 16 July 2006 ,Revised 6 August 2007 ,Accepted 8 August 2007.

References 

  1. Kelly AJ, Kavanagh J, Thomas J. Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term. Cochrane Database Syst Rev 2003 (4). Art. No.: CD003101. doi:10.1002/14651858.CD003101.
  2. Chyu JK, Strassner HT. Prostaglandin E2 for cervical ripening: a randomized comparison of Cervidil versus Prepidil. Am J Obstet Gynecol. 1997;177:606–611
  3. Ottinger WS, Menard MK, Brost BC. A randomized clinical trial of prostaglandin E2 intracervical gel and a slow release vaginal pessary for preinduction cervical ripening. Am J Obstet Gynecol. 1998;179:349–353
  4. Wieland D, Friedman F. Comparing two dinoprostone agents for preinduction cervical ripening at term. J Reprod Med. 1999;44:724–728
  5. Vollebregt A, van’t Hof DB, Exalto N. Prepidil compared to Propess for cervical ripening. Eur J Obstet Gynecol Reprod Biol. 2002;104:116–119
  6. Miller AM, Rayburn WF, Smith CV. Patterns of uterine activity after intravaginal prostaglandin E2 during preinduction cervical ripening. Am J Obstet Gynecol. 1991;165:1006–1009
  7. Green C, Pedder G, Mason G. A randomized trial of Propess against prostin gel for the induction of labour at term. Br J Obstet Gynaecol. 1998;105(Suppl. 17):82
  8. Rabl M, Joura EA, Yűcel Y, Egarter C. A randomized trial of vaginal prostaglandin E2 for induction of labor. Insert vs tablet. J Reprod Med. 2002;47:115–119
  9. Mukhopadhyay M, Lim KJH, Fairlie FM. Is propess a better method of induction of labour in nulliparous women?. J Obstet Gynaecol. 2002;22:294–295
  10. D’Aniello G, Bocchi C, Florio P, et al. Cervical ripening and induction of labor by prostaglandin E2: comparison between intracervical gel and vaginal pessary. J Matern Fetal Neonatal Med. 2003;14:158–162
  11. Facchinetti F, Venturini P, Verocchi G, Volpe A. Comparison of two preparations of dinoprostone for pre-induction of labour in nulliparous women with very unfavourable cervical condition: a randomized clinical trial. Eur J Obstet Gynecol Reprod Biol. 2005;119:189–193
  12. Strobelt N, Meregalli V, Ratti M, Mariani S, Zani G, Morana S. Randomized study on removable PGE2 vaginal insert versus PGE2 cervical gel for cervical priming and labor induction in low-Bishop-score pregnancy. Acta Obstet Gynecol Scand. 2006;85:302–305
  13. ACOG technical bulletin: induction of labor. Int J Gynaecol Obstet 1996; 53:65–72.
  14. Freeman RK. Problems with intrapartum fetal heart rate monitoring interpretation and patient management. Obstet Gynecol. 2002;100:813–826
  15. Zanini A, Ghidini A, Norchi S, Beretta E, Cortinovis I, Bottino S. Pre-induction cervical ripening with prostaglandin E2 gel: intracervical versus intravaginal route. Obstet Gynecol. 1990;76:681–683
  16. Arias F. Pharmacology of oxytocin and prostaglandins. Clin Obstet Gynecol. 2000;43:455–468
  17. Stewart JD, Rayburn WF, Farmer KC, Liles EM, Schipul AH, Stanley JR. Effectiveness of prostaglandin E2 intracervical gel (Prepidil), with immediate oxytocin, versus vaginal insert (Cervidil) for induction of labor. Am J Obstet Gynecol. 1998;179:1175–1180
  18. Hennessey MH, Rayburn WF, Stewart JD, Liles EC. Pre-eclampsia and induction of labor: a randomized comparison of prostaglandin E2 as an intracervical gel, with oxytocin immediately, or a sustained-release vaginal insert. Am J Obstet Gynecol. 1998;179:1204–1209
  19. Bolnick JM, Velazquez MD, Gonzalez JL, Rappaport VJ, McIlwain-Dunivan G, Rayburn WF. Randomized trial between two active labor management protocols in the presence of an unfavorable cervix. Am J Obstet Gynecol. 2004;190:124–128
  20. Papanikolaou EG, Plachouras N, Drougia A, et al. Comparison of misoprostol and dinoprostone for elective induction of labour in nulliparous women at full term: a randomized prospective study. Reprod Biol Endocrinol. 2004;2:70–77
  21. Ramsey PS, Meyer L, Walkes BA, et al. Cardiotocographic abnormalities associated with dinoprostone and misoprostol cervical ripening. Obstet Gynecol. 2005;105:85–90
  22. Megalo A, Petignat P, Hohlfeld P. Influence of misoprostol or prostaglandin E(2) for induction of labor on the incidence of pathological CTG tracing: a randomized trial. Eur J Obstet Gynecol Reprod Biol. 2004;116:34–38
  23. Sanchez-Ramos L, Kaunitz AM. Misoprostol for cervical ripening and labor induction: a systematic review of the literature. Clin Obstet Gynecol. 2000;43:475–488

 Preliminary account of this work was presented at the 2003 Annual Meeting of the Society for Gynecologic Investigation, Washington, DC.

PII: S0301-2115(07)00360-0

doi: 10.1016/j.ejogrb.2007.08.009

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 138, Issue 2 , Pages 135-140 , June 2008