European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 138, Issue 2 , Pages 152-157 , June 2008

Proliferative responses in the placenta after endotoxin exposure in preterm fetal sheep

  • Yves Garnier

      Affiliations

    • Department of Obstetrics and Gynecology, University Hospital RWTH Aachen, Germany
    • Department of Obstetrics and Gynecology, University Hospital Cologne, Germany
    • Corresponding Author InformationCorresponding author at: University Hospital of Cologne, Department of Obstetrics and Gynecology, Kerpenerstrasse 34, D-50924 Cologne, Germany. Tel.: +49 221 478 4910; fax: +49 221 478 4929.
    • ,
  • Mamed Kadyrov

      Affiliations

    • Institute of Anatomy II, University Hospital RWTH Aachen, Germany
    • ,
  • Markus Gantert

      Affiliations

    • Department of Obstetrics and Gynecology, University Hospital RWTH Aachen, Germany
    • Department of Obstetrics and Gynecology, University Hospital Cologne, Germany
    • ,
  • Anke Einig

      Affiliations

    • Department of Obstetrics and Gynecology, University Hospital RWTH Aachen, Germany
    • Institute of Anatomy II, University Hospital RWTH Aachen, Germany
    • ,
  • Werner Rath

      Affiliations

    • Department of Obstetrics and Gynecology, University Hospital RWTH Aachen, Germany
    • ,
  • Berthold Huppertz

      Affiliations

    • Institute of Anatomy II, University Hospital RWTH Aachen, Germany
    • Institute of Cell Biology, Histology and Embryology, Medical University Graz, Austria

Received 2 August 2006 ,Revised 5 August 2007 ,Accepted 22 August 2007.

References 

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  2. Dammann O, Leviton A. Infection remote from the brain, neonatal white matter damage, and cerebral palsy in the preterm infant. Semin Pediatr Neurol. 1998;5:190–201
  3. Garnier Y, Coumans AB, Jensen A, Hasaart TH, Berger R. Infection-related perinatal brain injury: the pathogenic role of impaired fetal cardiovascular control. J Soc Gynecol Investig. 2003;10:450–459
  4. Grether JK, Nelson KB. Maternal infection and cerebral palsy in infants of normal birth weight. JAMA. 1997;278:207–211
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  6. Yoon BH, Romero R, Park JS, et al. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol. 2000;182:675–681
  7. Lahra MM, Jeffery HE. A fetal response to chorioamnionitis is associated with early survival after preterm birth. Am J Obstet Gynecol. 2004;190:147–151
  8. Wu YW, Colford JM. Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. JAMA. 2000;284:1417–1424
  9. Coumans AB, Garnier Y, Supcun S, Jensen A, Berger R, Hasaart TH. The effects of low-dose endotoxin on the umbilicoplacental circulation in preterm sheep. J Soc Gynecol Investig. 2004;11:289–293
  10. Garnier Y, Coumans A, Jensen A, Berger R, Hasaart THM. Endotoxaemiamia severely affects circulation during normoxia and asphyxia in immature fetal sheep. J Soc Gynecol Investig. 2001;8:134–142
  11. Garnier Y, Berger R, Alm S, et al. Systemic endotoxin administration results in increased S100B protein blood levels and periventricular brain white matter injury in the preterm fetal sheep. Eur J Obstet Gynecol Reprod Biol. 2006;124:15–22
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  13. Opal SM, Scannon PJ, Vincent JL, White M, Carroll SF, Palardy JE, et al. Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock. J Infect Diss. 1999;180:1584–1589
  14. Sato TA, Keelan JA, Mitchell MD. Critical paracrine interactions between TNF-alpha and IL-10 regulate lipopolysaccharide-stimulated human choriodecidual cytokine and prostaglandin E2 production. J Immunol. 2003;170:158–166
  15. Malek A, Sager R, Schneider H. Effect of hypoxia, oxidative stress and lipopolysaccharides on the release of prostaglandins and cytokines from human term placental explants. Placenta. 2001;22(Suppl. A):S45–S50
  16. Ejima K, Koji T, Tsuruta D, Nanri H, Kashimura M, Ikeda M. Induction of apoptosis in placentas of pregnant mice exposed to lipopolysaccharides: possible involvement of Fas/Fas ligand system. Biol Reprod. 2000;62:178–185
  17. Asagiri K, Nakatsuka M, Konishi H, et al. Involvement of peroxynitrite in LPS-induced apoptosis of trophoblasts. J Obstet Gynaecol Res. 2003;29:49–55
  18. Duncan JR, Cock ML, Rees S, Harding R. The effects of repeated endotoxin exposure on placental structure in sheep. Placenta. 2003;24:786–789
  19. Adamson SL, Whiteley KJ, Langille BL. Endothelin-1 constricts fetoplacental microcirculation and decreases fetal O2 consumption in sheep. Am J Physiol. 1996;270:H16–H23
  20. Wanecek M, Weitzberg E, Rudehill A, Oldner A. The endothelin system in septic and endotoxin shock. Eur J Pharmacol. 2000;407:1–15
  21. Battistini B, Forget MA, Laight D. Potential roles for endothelins in systemic inflammatory response syndrome with a particular relationship to cytokines. Shock. 1996;5:167–183
  22. Lundberg JM, Ahlborg G, Hemsen A, et al. Evidence for release of endothelin-1 in pigs and humans. J Cardiovasc Pharmacol. 1991;17(Suppl.):350–353

☆ The paper contains data that has been presented at, and awarded a prize by, the German Society for Gynaecology and Obstetrics in 2004.

PII: S0301-2115(07)00365-X

doi: 10.1016/j.ejogrb.2007.08.016

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 138, Issue 2 , Pages 152-157 , June 2008

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