European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 138, Issue 2 , Pages 176-179 , June 2008

Isosorbide mononitrate vaginal gel versus misoprostol vaginal gel versus Dilapan-S® for cervical ripening before first trimester curettage

  • Frank Chih-Kang Chen

      Affiliations

    • Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Geburtsmedizin, Augustenburger Platz 1, 13353 Berlin, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 30 450 664069; fax: +49 30 4505 64901.
    • ,
  • Anna Bergann

      Affiliations

    • Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Frauenheilkunde und Geburtshilfe, Germany
    • ,
  • Jana Kroße

      Affiliations

    • Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Frauenheilkunde und Geburtshilfe, Germany
    • ,
  • Andrea Merholz

      Affiliations

    • Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Frauenheilkunde und Geburtshilfe, Germany
    • ,
  • Matthias David

      Affiliations

    • Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Frauenheilkunde und Geburtshilfe, Germany

Received 12 June 2006 ,Revised 18 July 2007 ,Accepted 17 September 2007.

References 

  1. Chwalisz K, Garfield E. Role of nitric oxide in the uterus and cervix: implications for the management of labor. J Perinat Med. 1998;26:448–457
  2. Bugalho A, Bique C, Almeida L, Bergstrom S. Application of vaginal misoprostol before cervical dilatation to facilitate first-trimester pregnancy interruption. Obstet Gynecol. 1994;83:729–731
  3. Esteve JL, Varela L, Velazco A, Tanda R, Cabezas E, Sanchez C. Early abortion with 800 micrograms of misoprostol by the vaginal route. Contraception. 1999;59:219–225
  4. Elsheikh A, Antsaklis A, Mesogitis S, et al. Use of misoprostol for the termination of second trimester pregnancies. Arch Gynecol Obstet. 2001;265:204–206
  5. Ekerhovd E, Bullarbo M, Andersch B, Norström A. Vaginal administration of the nitric oxide donor isosorbide mononitrate for cervical ripening at term: a randomized controlled study. Am J Obstet Gynecol. 2003;189:1692–1697
  6. David M, Chen FCK, Lichtenegger W. NO-donor nitroglycerin versus prostaglandin gemeprost for cervical ripening in the first trimester missed abortion. Int J Gynaecol Obstet. 2003;83:71–72
  7. Arteaga-Troncoso G, Villegas-Alvarado A, Belmont-Gomez A, Martinez-Herrera FJ, Villagrana-Zesati R, Guerra-Infante F. Intracervical application of the nitric oxide donor isosorbide dinitrate for induction of cervical ripening: a randomised controlled trial to determine clinical efficacy and safety prior to first trimester surgical evacuation of retained products of conception. BJOG. 2005;112:1615–1619
  8. Hidar S, Bouddebous M, Chaieb A, Jerbi M, Bibi M, Khairi H. Randomized controlled trial of vaginal misoprostol versus vaginal misoprostol and isosorbide dinitrate for termination of pregnancy at 13–29 weeks. Arch Gynecol Obstet. 2005;273:157–160
  9. Sharma Y, Kumar S, Mittal S, Misra R, Dadhwal V. Evaluation of glyceryl trinitrate, misoprostol, and prostaglandin E2 gel for preinduction cervical ripening in term pregnancy. J Obstet Gynecol Res. 2005;31:210–215
  10. Osman I, MacKenzie F, Norrie J, Murray HM, Greer IA, Norman JE. The “PRIM” study: a randomized comparison of prostaglandin E2 gel with the nitric oxide donor isosorbide mononitrate for cervical ripening before the induction of labor at term. Am J Obstet Gynecol. 2006;194:1012–1021
  11. Kline SB, Meng H, Munsick RA. Cervical dilation from laminara tents and synthetic osmotic dilators used for 6h before abortion. Obstet Gynecol. 1999;86:931–935
  12. Goldberg AB, Drey EA, Whitaker AK, Kang MS, Meckstroth KR, Darney PD. Misoprostol compared with laminaria before early second-trimester surgical abortion: a randomized trial. Obstet Gynecol. 2005;106:234–241
  13. David M, Chen FC. Comparison of isosorbide mononitrate (Mono Mack) and misoprostol (Cytotec) for cervical ripening in the first trimester missed abortion. Arch Gynecol Obstet. 2005;273:144–145
  14. Vaisanen-Tommiska M, Mikkola TS, Ylikorkala O. Misoprostol induces cervical nitric oxide release in pregnant, but not in nonpregnant, women. Am J Obstet Gynecol. 2005;193:790–796
  15. Edelman AB, Buckmaster JG, Goetsch MF, Nichols MD, Jensen JT. Cervical preparation using laminaria with adjunctive buccal misoprostol before second-trimester dilation and evacuation procedures: a randomized clinical trial. Am J Obstet Gynecol. 2006;194:425–430

PII: S0301-2115(07)00429-0

doi: 10.1016/j.ejogrb.2007.09.009

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 138, Issue 2 , Pages 176-179 , June 2008

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