European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 139, Issue 1 , Pages 46-52 , July 2008

Longitudinal changes in the continuous glucose profile measured by the CGMS® in healthy pregnant women and determination of cut-off values

  • Tina Siegmund

      Affiliations

    • Clinic of Obstetrics, Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany
  • ,
  • Neda Talai Rad

      Affiliations

    • Clinic of Obstetrics, Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany
  • ,
  • Claudia Ritterath

      Affiliations

    • Clinic of Obstetrics, Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany
  • ,
  • Gerda Siebert

      Affiliations

    • Institute of Medical Biometry, Universitätsmedizin Berlin, Berlin, Germany
  • ,
  • Wolfgang Henrich

      Affiliations

    • Clinic of Obstetrics, Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany
  • ,
  • Kai J. Buhling

      Affiliations

    • Clinic of Obstetrics, Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany
    • Department of Gynecologic Endocrinology, Universitätsfrauenklinik Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 30 4505 64293; fax: +49 30 4505 64901.

Received 4 March 2007 ,Revised 12 November 2007 ,Accepted 17 December 2007.

References 

  1. Buch I, Hornnes PJ, Kühl C. Glucose tolerance in early pregnancy. Acta Endocrinol. 1986;112:263–266
  2. Kühl C. Glucose metabolism during and after pregnancy in normal and gestational diabetic women. Acta Endocrinol. 1975;79:709–719
  3. Kühl C, Holst J. Plasma glucagon and the insulin: glucagon ratio in gestational diabetes. Diabetes. 1976;25(1):16–23
  4. American Diabetes Association (ADA) . Gestational diabetes mellitus. Diabetes Care. 2002;25:94–96
  5. German Diabetes Association. Guidelines of the working group Diabetes and Pregnancy (also available at http://www.deutsche-diabetes-gesellschaft.de, updated June 2001).
  6. De Veciana M. Glucose monitoring in women with insulin requiring gestational diabetes mellitus. Diabetes Metab Rev. 1998;14:25–30
  7. Homko CJ, Sivan E, Reece EA. Is self-monitoring of blood glucose necessary in the management of gestational diabetes mellitus?. Diabetes Care. 1998;21:B118–B122
  8. Kjos SL, Buchanan TA. Gestational diabetes mellitus. N Engl J Med. 1999;23:1749–1756
  9. Metzger BE, Coustan DR. The organizing committee: summary and recommendations of the Fourth International Workshop-Conference on GDM. Diabetes Care. 1998;21:B161–B167
  10. Koschinsky T, Heinemann L. Sensors for glucose monitoring: technical and clinical aspects. Diabetes Metab Res. 2001;17:113–123
  11. Buhling KJ, Kurzidim B, Wolf C, et al. Introductory experience with the continuous glucose monitoring system (CGMS®; Medtronic Minimed®) in detecting hyperglycemia by comparing the self-monitoring of blood glucose (SMBG) in non-pregnant women and in pregnant women with impaired glucose tolerance and gestational diabetes. Exp Clin Endocrinol Diabetes. 2004;112:556–560
  12. Buhling KJ, Winkler T, Wolf C, et al. Optimal timing for postprandial glucose measurement in pregnant women with diabetes and a non-diabetic pregnant population evaluated by the continuous glucose monitoring system (CGMS®). J Perinat Med. 2005;33:125–131
  13. Langer O. Ultrasound biometry evolves in the management of diabetes in pregnancy. Ultrasound Obstet Gynecol. 2005;26:585–595
  14. Cousins L, Rigg L, Hollingsworth D, Brink G, Aurand J, Yen SS. The 24-h excursion and diurnal rhythm of glucose, insulin, and C-peptide in normal pregnancy. Am J Obstet Gynecol. 1980;136:483–488
  15. Gillmer MD, Beard RW, Brooke FM, Oakley NW. Carbohydrate metabolism in pregnancy. Part I. Diurnal plasma glucose profile in normal and diabetic woman. BMJ. 1975;16:399–402
  16. Phelps RL, Metzger BE, Freinkel N. Carbohydrate metabolism in pregnancy: XVII, diurnal profiles of plasma glucose, insulin, free fatty acids, triglycerides, cholesterol, and individual amino acids in late normal pregnancy. Am J Obstet Gynecol. 1981;140:730–736
  17. Yogev Y, Avi BH, Rony C, Barak R, Moshe H, Oded L. Diurnal glycemic profile in obese and normal weight nondiabetic pregnant woman. Am J Obstet Gynecol. 2004;191:949–953
  18. Cypryk K, Pertynska-Marczewska M, Szymczak W, Wilcynski J, Lewinski A. Evaluation of metabolic control in women with gestational diabetes mellitus by the continuous glucose monitoring system: a pilot study. Endocrinol Pract. 2006;12(3):245–250
  19. Schumacher A, Sidor J, Buhling KJ. Continuous glucose monitoring using the glucose sensor CGMS® during betamethasone therapy in non-diabetic pregnant women. Z Geburtshilfe Neonatol. 2006;210:184–190
  20. Parretti E, Mecacci F, Papini M, et al. Third-trimester maternal glucose levels from diurnal profiles in nondiabetic pregnancies, correlation with sonographic parameters of fetal growth. Diabetes Care. 2001;24:1319–1323
  21. Sivan E, Reece EA, Chen X, Boden G, Homko CJ. Longitudinal study of carbohydrate metabolism in healthy obese pregnant women. Diabetes. 1997;20:1470–1475
  22. Jovanovic-Peterson L, Peterson CM, Reed GF. Maternal postprandial glucose levels and infant birth weight. The Diabetes in early pregnancy study. Am J Obstet Gynecol. 1991;164:103–111
  23. Porter H, Lookinland S, Belfort MA. Evaluation of a new real-time blood continuous glucose monitoring system in pregnant women without gestational diabetes. A pilot study. J Perinat Neonatal Nurs. 2004;18(2):93–102

PII: S0301-2115(07)00519-2

doi: 10.1016/j.ejogrb.2007.12.006

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 139, Issue 1 , Pages 46-52 , July 2008