European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 138, Issue 2 , Pages 180-186 , June 2008

Plasma homocysteine concentrations and the single nucleotide polymorphisms in the methionine synthase gene (MTR 2756A>G): Associations with the polycystic ovary syndrome: An observational study

  • M. Palep-Singh

      Affiliations

    • Department of Gynaecology, Saint Mary's University Teaching Hospital, CMMC NHS Trust, Hathersage Road, Manchester, M13 0JH, UK
    • Corresponding Author InformationCorresponding author at: Reproductive Medicine and Surgery, Department of Gynaecology, Saint Mary's University Teaching Hospital, CMMC NHS Trust, Hathersage Road, Manchester M13 0JH, UK. Tel.: +441612766358.
    • ,
  • H.M. Picton

      Affiliations

    • Reproduction & Early Development Research Group, Faculty of Medicine and Health, University of Leeds, D Floor Clarendon Wing, Belmont Grove, Leeds LS2 9NS, UK
    • ,
  • Z.R. Yates

      Affiliations

    • Reproduction & Early Development Research Group, Faculty of Medicine and Health, University of Leeds, D Floor Clarendon Wing, Belmont Grove, Leeds LS2 9NS, UK
    • ,
  • J.H. Barth

      Affiliations

    • Department of Chemical Pathology & Biochemistry, Leeds General Infirmary, Leeds LS2 9NS, UK
    • ,
  • A.H. Balen

      Affiliations

    • Reproductive Medicine Unit, Leeds Teaching Hospitals NHS Trust, C Floor Clarendon Wing, Belmont Grove, Leeds LS2 9NS, UK

Received 9 March 2007 ,Revised 13 November 2007 ,Accepted 27 December 2007.

References 

  1. Harmon DL, Shields DC, Woodside JV, et al. Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet Epidemiol. 1999;17(4):298–309
  2. Ma J, Stampfer MJ, Christensen B, et al. A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 1999;8(9):825–829
  3. Balen AH. The current understanding of polycystic ovary syndrome. Obstetr Gynaecol. 2004;6:66–74
  4. Wijeyaratne CN, Balen AH, Barth JH, Belchetz PE. Clinical manifestations and insulin resistance (IR) in polycystic ovary syndrome (PCOS) among South Asians and Caucasians: is there a difference?. Clin Endocrinol (Oxf). 2002;57(3):343–350
  5. Fauser BC. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41–47
  6. Balen AH, Laven JS, Tan SL, Dewailly D. Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update. 2003;9(6):505–514
  7. Palep-Singh M, Picton HM, Yates ZR, Barth J, Balen AH. Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study. Hum Fertil (Camb). 2007;10(1):33–41
  8. Talbott E, Guzick D, Clerici A, et al. Coronary heart disease risk factors in women with polycystic ovary syndrome. Arterioscler Thromb Vasc Biol. 1995;15(7):821–826
  9. Takahashi K, Okada M, Ozaki T, Uchida A, Yamasaki H, Kitao M. Transvaginal ultrasonographic morphology in polycystic ovarian syndrome. Gynecol Obstet Invest. 1995;39(3):201–206
  10. Wu MH, Tang HH, Hsu CC, Wang ST, Huang KE. The role of three-dimensional ultrasonographic images in ovarian measurement. Fertil Steril. 1998;69(6):1152–1155
  11. Herrmann W, Schorr H, Geisel J, Riegel W. Homocysteine, cystathionine, methylmalonic acid and B-vitamins in patients with renal disease. Clin Chem Lab Med. 2001;39(8):739–746
  12. Herrmann W, Schorr H, Purschwitz K, Rassoul F, Richter V. Total homocysteine, vitamin B(12), and total antioxidant status in vegetarians. Clin Chem. 2001;47(6):1094–1101
  13. Herrmann W. The importance of hyperhomocysteinemia as a risk factor for diseases: an overview. Clin Chem Lab Med. 2001;39(8):666–674
  14. Wijeyaratne CN, Nirantharakumar K, Balen AH, Barth JH, Sheriff R, Belchetz PE. Plasma homocysteine in polycystic ovary syndrome: does it correlate with insulin resistance and ethnicity?. Clin Endocrinol (Oxf). 2004;60(5):560–567
  15. Palep-Singh M, Picton HM, Barth JH, Balen AH. Ethnic variations in the distribution of obesity and biochemical metabolic abnormalities in fertility clinic attendees. J Reprod Med; in press.
  16. Loverro G, Lorusso F, Mei L, Depalo R, Cormio G, Selvaggi L. The plasma homocysteine levels are increased in polycystic ovary syndrome. Gynecol Obstet Invest. 2002;53(3):157–162
  17. Schachter M, Raziel A, Friedler S, Strassburger D, Bern O, Ron-El R. Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine. Hum Reprod. 2003;18(4):721–727
  18. Yates Z, Lucock M. Methionine synthase polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism. Haematologica. 2002;87(7):751–756
  19. Silaste ML, Rantala M, Sampi M, Alfthan G, Aro A, Kesaniemi YA. Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women. J Nutr. 2001;131(10):2643–2647
  20. Lee HC, Jeong YM, Lee SH, et al. Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility. Hum Reprod. 2006;21(12):3162–3170

PII: S0301-2115(08)00004-3

doi: 10.1016/j.ejogrb.2007.12.015

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 138, Issue 2 , Pages 180-186 , June 2008

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