Examination of the association between male gender and preterm delivery☆
Received 4 December 2007; received in revised form 22 March 2008; accepted 23 July 2008. published online 26 August 2008.
Abstract
Objective
To examine possible reasons why a male fetus constitutes a risk factor for preterm delivery.
Study design
Retrospective study of deliveries from hospital database in a UK teaching hospital. The population comprised all deliveries >23 weeks over an 11-year period, excluding multiples, terminations and pregnancies with major abnormalities including indeterminate gender. Obstetric variables and outcomes were initially compared in male and female babies for preterm births in different gestation bands, extreme (<28 weeks), severe (29–32 weeks) and moderate (33–36 weeks). For each, the odds ratios with 95% confidence intervals for preterm delivery were calculated. Then, using binary logistic regression with adjusted odds ratios with 95% confidence intervals, putative causal pathways that might explain the male excess were tested.
Results
75,725 deliveries occurred, of which 4003 (5.3%) were preterm. Males delivered preterm more frequently (OR 1.13, 95% CI 1.06–1.20). This was due to spontaneous (OR 1.30, 95% CI 1.19–1.42) but not iatrogenic (OR 0.96, 95% CI 0.87–1.05) preterm birth. There was an increased risk of pre eclampsia among preterm females. Although males were larger, and male pregnancies were more frequently nulliparous and affected by some other obstetric complications (abruption, urinary tract infection), these did not account for their increased risk. Any effect of growth restriction could not be properly determined.
Conclusions
Being male carries an increased risk of spontaneous but not iatrogenic preterm birth. The reasons behind this remain obscure.
ABSTRACT