European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 143, Issue 2 , Pages 79-83 , April 2009

The effect of extracellular adenosine triphosphate on the spontaneous contractility of human myometrial strips

  • Graham Hutchings

      Affiliations

    • Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    • Corresponding Author InformationCorresponding author at: Department of Obstetrics, 10th Floor, Cliniques Universitaires St Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium. Tel.: +32 2 764 1008; fax: +32 2 764 8913.
    • ,
  • Thomas Gevaert

      Affiliations

    • Department of Urology, University Hospital Gasthuisberg, Leuven, Belgium
    • ,
  • Jan Deprest

      Affiliations

    • Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    • ,
  • Bernd Nilius

      Affiliations

    • Department of Physiology, University Hospital Gasthuisberg, Leuven, Belgium
    • ,
  • Olivia Williams

      Affiliations

    • Department of Neonatology, Cliniques Universitaires St Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium
    • ,
  • Dirk De Ridder

      Affiliations

    • Department of Urology, University Hospital Gasthuisberg, Leuven, Belgium

Received 9 July 2008 ,Revised 29 October 2008 ,Accepted 28 December 2008.

References 

  1. Garfield RE, Ali M, Yallampalli C, Izumi H. Role of gap junctions and nitric oxide in control of myometrial contractility. Semin Perinatol. 1995;19(1):41–51
  2. Turnbull AC, Anderson AB. Uterine contractility and oxytocin sensitivity during human pregnancy in relation to the onset of labour. J Obstet Gynaecol Br Commonw. 1968;75(3):278–288
  3. Bulletti C, de Ziegler D. Uterine contractility and embryo implantation. Curr Opin Obstet Gynecol. 2005;17(3):265–276
  4. Bulletti C, de Ziegler D, Polli V, Diotallevi L, Del Ferro E, Flamigni C. Uterine contractility during the menstrual cycle. Hum Reprod. 2000;15(Suppl 1):81–89
  5. Kunz G, Beil D, Huppert P, Leyendecker G. Control and function of uterine peristalsis during the human luteal phase. Reprod Biomed Online. 2006;13(4):528–540
  6. Young RC, Zhang P. Inhibition of in vitro contractions of human myometrium by mibefradil, a T-type calcium channel blocker: support for a model using excitation–contraction coupling, and autocrine and paracrine signalling mechanisms. J Soc Gynecol Investig. 2005;12(May (4)):e7–e12
  7. Young RC. Tissue-level signaling and control of uterine contractility: the action potential-calcium wave hypothesis. J Soc Gynecol Investig. 2000;7(May–June (3)):146–152[Review]
  8. Young RC, Schumann R, Zhang P. The signalling mechanisms of long distance intercellular calcium waves (far waves) in cultured human uterine myocytes. J Muscle Res Cell Motil. 2002;23(4):279–284
  9. Hutchings G, Gevaert T, Deprest J, et al. Immunohistochemistry using an antibody to unphosphorylated connexin 43 to identify human myometrial interstitial cells. Reprod Biol Endocrinol. 2008;6:43;[September 16, 2008]
  10. Hirst GD, Edwards FR. Role of interstitial cells of Cajal in the control of gastric motility. J Pharmacol Sci. 2004;96(1):1–10
  11. Ziganshin AU, Zefirova JT, Zefirova TP, Ziganshina LE, Hoyle CH, Burnstock G. Potentiation of uterine effects of prostaglandin F2 alpha by adenosine 5′-triphosphate. Obstet Gynecol. 2005;105(6):1429–1436
  12. Shmygol A, Wray S. Modulation of agonist-induced Ca2+ release by SR Ca2+ load: direct SR and cytosolic Ca2+ measurements in rat uterine myocytes. Cell Calcium. 2005;37(3):215–223
  13. Piper AS, Hollingsworth M. P2-purinoceptors mediating spasm of the isolated uterus of the non-pregnant guinea-pig. Br J Pharmacol. 1996;117(8):1721–1729
  14. Aitken H, Poyser NL, Hollingsworth M. The effects of P2Y receptor agonists and adenosine on prostaglandin production by the guinea-pig uterus. Br J Pharmacol. 2001;132(3):709–721
  15. Blanks AM, Shmygol A, Thornton S. Regulation of oxytocin receptors and oxytocin receptor signaling. Semin Reprod Med. 2007;25(January (1)):52–59
  16. Word RA, Kamm KE, Casey ML. Contractile effects of prostaglandins, oxytocin and endothelin-1 in human myometrium in vitro: refractoriness of myometrial tissue of pregnant women to prostaglandin E2 and F2 alpha. J Clin Endocrinol Metab. 1992;75(October (4)):1027–1032

PII: S0301-2115(09)00013-X

doi: 10.1016/j.ejogrb.2008.12.004

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 143, Issue 2 , Pages 79-83 , April 2009

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