European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 143, Issue 2 , Pages 75-78 , April 2009

The safety of quinolones—A meta-analysis of pregnancy outcomes

  • Benjamin Bar-Oz

      Affiliations

    • The Motherisk Program, Hospital for Sick Children, Toronto, Canada
    • Department of Neonatology, Hadassah and Hebrew University Medical Center, Jerusalem, Israel
    • Corresponding Author InformationCorresponding author at: Department of Neonatology, Hadassah and Hebrew University Medical Center, Mount Scopus P.O.B 24035, Jerusalem 91240, Israel. Tel.: +972 2 5844432; fax: +972 2 5813068.
  • ,
  • Myla E. Moretti

      Affiliations

    • The Motherisk Program, Hospital for Sick Children, Toronto, Canada
  • ,
  • Radinka Boskovic

      Affiliations

    • The Motherisk Program, Hospital for Sick Children, Toronto, Canada
  • ,
  • Lisa O’Brien

      Affiliations

    • The Motherisk Program, Hospital for Sick Children, Toronto, Canada
  • ,
  • Gideon Koren

      Affiliations

    • The Motherisk Program, Hospital for Sick Children, Toronto, Canada

Received 22 May 2008 ,Revised 12 November 2008 ,Accepted 28 December 2008.

References 

  1. Hooper DC. Mechanisms of action of antimicrobials: focus on fluoroquinolones. Clin Infect Dis. 2001;32(Suppl 1):S9–S15
  2. Giamarellou H, Kolokythas E, Petrikkos G, Gazis J, Aravantinos D, Sfikakis P. Pharmacokinetics of three newer quinolones in pregnant and lactating women. Am J Med. 1989;87(5A):49S–51S
  3. Linseman DA, Hampton LA, Branstetter DG. Quinolone-induced arthropathy in the neonatal mouse. Morphological analysis of articular lesions produced by pipemidic acid and ciprofloxacin. Fundam Appl Toxicol. 1995;28(1):59–64
  4. Yabe K, Satoh H, Ishii Y, et al. Early pathophysiologic feature of arthropathy in juvenile dogs induced by ofloxacin, a quinolone antimicrobial agent. Vet Pathol. 2004;41(6):673–681
  5. von Keutz E, Ruhl-Fehlert C, Drommer W, Rosenbruch M. Effects of ciprofloxacin on joint cartilage in immature dogs immediately after dosing and after a 5-month treatment-free period. Arch Toxicol. 2004;78(7):418–424
  6. Danisovicova A, Brezina M, Belan S, et al. Magnetic resonance imaging in children receiving quinolones: no evidence of quinolone-induced arthropathy. A multicenter survey. Chemotherapy. 1994;40(3):209–214
  7. Ferech M, Coenen S, Malhotra-Kumar S, et al. European Surveillance of Antimicrobial Consumption (ESAC): outpatient quinolone use in Europe. J Antimicrob Chemother. 2006;58(2):423–427
  8. Goossens H, Ferech M, Vander SR, Elseviers M. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet. 2005;365(9459):579–587
  9. Linder JA, Huang ES, Steinman MA, Gonzales R, Stafford RS. Fluoroquinolone prescribing in the United States: 1995 to 2002. Am J Med. 2005;118(3):259–268
  10. Berkovitch M, Pastuszak A, Gazarian M, Lewis M, Koren G. Safety of the new quinolones in pregnancy. Obstet Gynecol. 1994;84(4):535–538
  11. Czeizel AE, Sorensen HT, Rockenbauer M, Olsen J. A population-based case–control teratologic study of nalidixic acid. Int J Gynaecol Obstet. 2001;73(3):221–228
  12. Dudas I, Puho E, Czeizel AE. Population-based case–control study of oxoline acid use during pregnancy for birth outcomes. Congenit Anom (Kyoto). 2006;46(1):39–42
  13. Koren G. Use of the new quinolones during pregnancy. Can Fam Phys. 1996;42:1097–1099
  14. Larsen H, Nielsen GL, Schonheyder HC, Olesen C, Sorensen HT. Birth outcome following maternal use of fluoroquinolones. Int J Antimicrob Agents. 2001;18(3):259–262
  15. Schaefer C, Amoura-Elefant E, Vial T, et al. Pregnancy outcome after prenatal quinolone exposure. Evaluation of a case registry of the European Network of Teratology Information Services (ENTIS). Eur J Obstet Gynecol Reprod Biol. 1996;69(2):83–89
  16. Wilton LV, Pearce GL, Mann RD. A comparison of ciprofloxacin, norfloxacin, ofloxacin, azithromycin and cefixime examined by observational cohort studies. Br J Clin Pharmacol. 1996;41(4):277–284
  17. Wogelius P, Norgaard M, Gislum M, Pedersen L, Schonheyder HC, Sorensen HT. Further analysis of the risk of adverse birth outcome after maternal use of fluoroquinolones. Int J Antimicrob Agents. 2005;26(4):323–326
  18. Loebstein R, Addis A, Ho E, et al. Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study. Antimicrob Agents Chemother. 1998;42(6):1336–1339
  19. Einarson TR. Pharmacoeconomic applications of meta-analysis for single groups using antifungal onychomycosis lacquers as an example. Clin Ther. 1997;19(3):559–569
  20. Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52(6):377–384
  21. Ferrero S, Ragni N. Inflammatory bowel disease: management issues during pregnancy. Arch Gynecol Obstet. 2004;270(2):79–85
  22. Bomford JAL, Ledger JC, O’Keeffe BJ, Reiter C. Ciprofloxacin use during pregnancy. Drugs. 1993;45(Suppl 3):461–462
  23. Koul PA, Wani JI, Wahid A. Ciprofloxacin for multiresistant enteric fever in pregnancy. Lancet. 1995;346(8970):307–308
  24. Moskovitz DN, Bodian C, Chapman ML, et al. The effect on the fetus of medications used to treat pregnant inflammatory bowel-disease patients. Am J Gastroenterol. 2004;99(4):656–661
  25. Santolaria N, Vial T, Bellemin B, Evreux IC. Pregnancy outcome after first trimester fluoroquinolone exposure. Therapie. 1998;53(4):179
  26. Pastuszak A, Andreou R, Schick B, et al. New postmarketing surveillance data supports a lack of association between quinolone use in pregnancy and fetal and neonatal complications. Reprod Toxicol. 1995;9(6):584
  27. Camp BW, Broman SH, Nichols PL, Leff M. Maternal and neonatal risk factors for mental retardation: defining the ‘at-risk’ child. Early Hum Dev. 1998;50(2):159–173

PII: S0301-2115(09)00016-5

doi: 10.1016/j.ejogrb.2008.12.007

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 143, Issue 2 , Pages 75-78 , April 2009