European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 144, Issue 1 , Pages 27-31 , May 2009

Inflammatory cytokine mRNA detection by real time PCR in chorioamniotic membranes from pregnant women with preterm premature rupture of membranes

  • J. Polettini

      Affiliations

    • Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil
    • ,
  • J.C. Peraçoli

      Affiliations

    • Department of Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil
    • ,
  • J.M.G. Candeias

      Affiliations

    • Department of Microbiology and Immunology, Institute of Biosciences, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil
    • ,
  • J.P. Araújo Júnior

      Affiliations

    • Department of Microbiology and Immunology, Institute of Biosciences, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil
    • ,
  • M.G. Silva

      Affiliations

    • Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil
    • Corresponding Author InformationCorresponding author at: Department of Pathology, Botucatu Medical School, São Paulo State University, Distrito de Rubião Júnior, CEP: 18618-970, Botucatu, São Paulo, Brazil. Tel.: +55 14 3811 6238; fax: +55 14 3815 2348.

Received 3 July 2008 ,Revised 9 December 2008 ,Accepted 19 January 2009.

References 

  1. Lee T, Silver H. Etiology and epidemiology of preterm premature rupture of the membranes. Clin Perinatol. 2001;28:721–734
  2. Silverman RK, Wojtowycz M. Risk factors in premature rupture of membranes. Prim Care Update Ob Gyns. 1998;5:181
  3. Simhan HN, Caritis SN, Krohn MA, Hillier SL. The vaginal inflammatory milieu and risk of early premature preterm rupture of membranes. Am J Obstet Gynecol. 2005;192:213–218
  4. Casanueva E, Ripoll C, Meza-Camacho C, Coutiño B, Ramírez-Peredo J, Parra A. Possible interplay between vitamin C deficiency and prolactin in pregnant women with premature rupture of membranes: facts and hypothesis. Med Hypotheses. 2005;64:241–247
  5. Yang J, Hartmann KE, Savitz DA, et al. Vaginal bleeding during pregnancy and preterm birth. Am J Epidemiol. 2004;160:118–125
  6. Purwar M, Ughade S, Bhagat B, Agarwal V, Kulkarni H. Bacterial vaginosis in early pregnancy and adverse pregnancy outcome. J Obstet Gynaecol Res. 2001;27:175–181
  7. Gonçalves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev. 2002;8:3–13
  8. Menon R, Fortunato SJ. Fetal membranes inflammatory cytokines: a switching mechanism between the preterm premature rupture of membranes and preterm labor pathways. J Perinat Med. 2004;32:391–399
  9. Jacobsson B, Mattsby-Baltzer I, Andersch B, et al. Microbial invasion and cytokine response in amniotic fluid in a Swedish population of women with preterm prelabor rupture of membranes. Acta Obstet Gynecol Scand. 2003;82:423–431
  10. Shobokshi A, Shaarawy M. Maternal serum and amniotic fluid cytokines in patients with preterm premature rupture of membranes with and without intrauterine infection. Int J Gynecol Obstet. 2002;79:209–215
  11. Menon R, Swan KF, Lyden TW, Rote NS, Fortunato S. Expression of inflammatory cytokines (interleukin-1β and interleukin-6) in amniochorionic membranes. Am J Obstet Gynecol. 1995;172:493–500
  12. Fortunato SJ, Menon R, Bryant C, Lombardi SJ. Programmed cell death (apoptosis) as a possible pathway to metalloproteinase activation and fetal membrane degradation in premature rupture of membranes. Am J Obstet Gynecol. 2000;182:1468–1476
  13. Fortunato SJ, Menon R, Lombardi SJ. Role of tumor necrosis factor-α in the premature rupture of membranes and preterm labor pathways. Am J Obstet Gynecol. 2002;187:1159–1162
  14. Bowen JM, Chamley L, Keelan JA, Mitchell MD. Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition. Placenta. 2002;23:257–273
  15. Laham N, Brennecke SP, Rice GE. Interleukin-8 release from human gestational tissue explants: effect of gestation, labor, and chorioamnionitis. Biol Reprod. 1999;61:823–827
  16. Dudley DJ, Collmer D, Mitchell MD, Trautman MS. Inflammatory cytokine mRNA in human gestational tissues: implications for term and preterm labor. J Soc Gynecol Investig. 1996;3:328–335
  17. Holst RM, Laurini R, Jacobsson B, et al. Expression of cytokines and chemokines in cervical and amniotic fluid: relationship to histological chorioamnionitis. J Matern Fetal Neonatal Med. 2007;20:885–893
  18. Hargitai B, Marton T, Cox PM. Examination of the human placenta. J Clin Pathol. 2004;57:785–792
  19. Figueroa R, Garry D, Elimian A, Patel K, Sehgal PB, Tejani N. Evaluation of amniotic fluid cytokines in preterm labor and intact membranes. J Matern Fetal Neonatal Med. 2005;18:241–247
  20. Daher S, Fonseca F, Ribeiro OG, Musatti CC, Gerbase-DeLima M. Tumor necrosis factor during pregnancy and the onset of labor and spontaneous abortion. Eur J Obstet Gynecol Reprod Biol. 1999;83:77–79
  21. Hirsch E, Filipovich Y, Mahendroo M. Signaling via the type I IL-1 and TNF receptors is necessary for bacterially-induced preterm labor in a murine model. Am J Obstet Gynecol. 2006;194:1334–1340
  22. Ghidini A, Salafia CM, Kirn V, Doria V, Spong CY. Biophysical profile in predicting acute ascending infection in preterm rupture of membranes before 32 weeks. Obstet Gynecol. 2000;96:201–206
  23. Hendsch SA, Stephens L, Markenson G, Bsat F. Prediction of pregnancy outcome in preterm premature rupture of membranes using vaginal pool amniotic fluid markers. Obstet Gynecol. 2001;97:S5
  24. Silva MG, Peraçoli JC, Sadatsune T, Abreu ES, Peraçoli MTS. Cervical Lactobacillus and leukocyte infiltration in preterm premature rupture of membranes. Int J Gynecol Obstet. 2003;81:175–182
  25. Conti P, Kempuraj D, Kandere K, et al. IL-10, an inflammatory/inhibitory cytokine, but not always. Immunol Lett. 2003;86:123–129
  26. Zhao Y, Li S, Tong X. Serum concentration of interleukin-6 in maternal serum and its expression in amniochorionic membranes of preterm premature rupture of membrane. Zhonghua Fu Chan Ke Za Zhi. 1999;34:138–139

PII: S0301-2115(09)00070-0

doi: 10.1016/j.ejogrb.2009.01.008

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 144, Issue 1 , Pages 27-31 , May 2009

Article Tools

* Image Usage & Resolution