European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 144, Issue 1 , Pages 44-47 , May 2009

Leiomyoma pseudocapsule after pre-surgical treatment with gonadotropin-releasing hormone agonists: Relationship between clinical features and immunohistochemical changes

  • Marianna De Falco

      Affiliations

    • Department of Obstetrical-Gynaecological and Urological Science and Reproductive Medicine, University “Federico II” of Naples, Via S. Pansini, 5, 80131 Naples, Italy
    • ,
  • Stefania Staibano

      Affiliations

    • Department of Biomorphological and Functional Science, University “Federico II” of Naples, Via S. Pansini, 5, 80131 Naples, Italy
    • ,
  • Massimo Mascolo

      Affiliations

    • Department of Biomorphological and Functional Science, University “Federico II” of Naples, Via S. Pansini, 5, 80131 Naples, Italy
    • ,
  • Chiara Mignogna

      Affiliations

    • Department of Biomorphological and Functional Science, University “Federico II” of Naples, Via S. Pansini, 5, 80131 Naples, Italy
    • ,
  • Luigi Improda

      Affiliations

    • Department of Obstetrical-Gynaecological and Urological Science and Reproductive Medicine, University “Federico II” of Naples, Via S. Pansini, 5, 80131 Naples, Italy
    • ,
  • Francesca Ciociola

      Affiliations

    • Department of Obstetrical-Gynaecological and Urological Science and Reproductive Medicine, University “Federico II” of Naples, Via S. Pansini, 5, 80131 Naples, Italy
    • ,
  • Ilma F. Carbone

      Affiliations

    • Department of Obstetrical-Gynaecological and Urological Science and Reproductive Medicine, University “Federico II” of Naples, Via S. Pansini, 5, 80131 Naples, Italy
    • ,
  • Andrea Di Lieto

      Affiliations

    • Department of Obstetrical-Gynaecological and Urological Science and Reproductive Medicine, University “Federico II” of Naples, Via S. Pansini, 5, 80131 Naples, Italy
    • Corresponding Author InformationCorresponding author at: Via Luca Giordano, 120, 80127, Napoli, Italy. Tel.: +39 081 746 2954; fax: +39 081 746 2954.

Received 3 July 2008 ,Revised 22 December 2008 ,Accepted 4 February 2009.

References 

  1. Lethaby A, Vollenhoven B, Sowter M. Pre-operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids. Cochrane Library 2007 [issue 4].
  2. Stewart EA. Uterine fibroids. Lancet. 2001;357:293–298
  3. In:  Martius H editors. Trattato di Ginecologia. Roma: Abruzzini Editore; 1953;
  4. Walocha JA, Litwin JA, Miodoński AJ. Vascular system of intramural leiomyomata revealed by corrosion casting and scanning electron microscopy. Hum Reprod. 2003;18(5):1088–1093
  5. De Falco M, Staibano S, Pollio F, et al. Expression of proliferating cell nuclear antigen and bcl-2 during a pseudomenopausal state induced by pre-surgical treatment of uterine leiomyomas with gonadotropin-releasing hormone analogues plus tibolone. Int J Gynecol Pathol. 2005;24(3):286–291
  6. De Falco M, Staibano S, D’Armiento FP, et al. Pre-operative treatment of uterine leiomyomas: clinical findings and expression of transforming growth factor-beta3 and connective tissue growth factor. J Soc Gynecol Investig. 2006;13(4):297–303
  7. Vercellini P, Trespidi L, Zaina B, Vicentini S, Stellato G, Crosignani PG. Gonadotropin-releasing hormone agonist treatment before abdominal myomectomy: a controlled trial. Fertil Steril. 2003;79(6):1390–1395
  8. Di Lieto A, De Falco M, Staibano S, et al. Effects of gonadotropin-releasing hormone agonists on uterine volume and vasculature and on the immunohistochemical expression of basic fibroblast growth factor (bFGF) in uterine leiomyomas. Int J Gynecol Pathol. 2003;22(4):353–358
  9. Di Lieto A, De Falco M, Pollio F, et al. Clinical response, vascular change, and angiogenesis in gonadotropin-releasing hormone analogue-treated women with uterine myomas. J Soc Gynecol Investig. 2005;12(2):123–128
  10. Dubuisson JB, Fauconnier A, Fourchotte V, Babaki-Fard K, Coste J, Chapron C. Laparoscopic myomectomy: predicting the risk of conversion to an open procedure. Hum Reprod. 2001;16(8):1726–1731
  11. Beyth Y. Gonadotropin-releasing hormone analog treatment should not precede conservative myomectomy [letter]. Fertil Steril. 1990;53:187–188
  12. Acien P, Quereda F. Abdominal myomectomy: results of a simple operative technique. Fertil Steril. 1996;65:41–51
  13. Sreenan JJ, Prayson RA, Biscotti CV, Thornton MH, Easley KA, Hart WR. Histopathologic findings in 107 uterine leiomyomas treated with leuprolide acetate compared with 126 controls. Am J Surg Pathol. 1996;20(4):427–432
  14. Mizutani T, Sugihara A, Nakamuro K, Terada N. Suppression of cell proliferation and induction of apoptosis in uterine leiomyoma by gonadotropin-releasing hormone agonist (leuprolide acetate). J Clin Endocrinol Metab. 1998;84(4):1253–1255
  15. Vu K, Greenspan DL, Wu TC, Zacur HA, Kurman RJ. Cellular proliferation, estrogen receptor, progesterone receptor, and Bcl-2 expression in GnRH agonist-treated uterine leiomyomas. Hum Pathol. 1998;29:359–363
  16. Huang SC, Chou CY, Lin YS, et al. Enhanced deoxyribonucleic acid damage and repair but unchanged apoptosis in uterine leiomyomas treated with gonadotropin-releasing hormone agonist. Am J Obstet Gynecol. 1997;177(2):417–424

PII: S0301-2115(09)00093-1

doi: 10.1016/j.ejogrb.2009.02.006

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 144, Issue 1 , Pages 44-47 , May 2009

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