Laparoscopic versus open myomectomy—A meta-analysis of randomized controlled trials

Jin, Chu; Hu, Yan; Chen, Xia-chan; Zheng, Fei-yun; Lin, Feng; Zhou, Kai; Chen, Feng-di; Gu, Hang-zhi

doi:10.1016/j.ejogrb.2009.03.009

« Previous Next »European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 145, Issue 1 , Pages 14-21, July 2009

Laparoscopic versus open myomectomy—A meta-analysis of randomized controlled trials

Chu Jin
- School of Information and Engineering, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
- Co-first author, contributed equally.
Yan Hu
- Department of Gynecology, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
- Co-first author, contributed equally.
Xia-chan Chen
- Medical Department, Run’an People's Hospital, Wenzhou 325000, Zhejiang Province, China
Fei-yun Zheng
- Department of Gynecology, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
Feng Lin
- Department of Gynecology, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
- Corresponding author. Tel.: +86 0577 88117586; fax: +86 0577 88069555.
Kai Zhou
- Department of Gynecology, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
Feng-di Chen
- Department of Gynecology, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
Hang-zhi Gu
- Department of Gynecology, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China

Received 18 January 2008; received in revised form 23 January 2009; accepted 1 March 2009. published online 10 April 2009.

Abstract

The objective of this study was to determine the better method of myomectomy by comparing laparoscopic and open myomectomy for patients with fibroids with regard to operative parameters and outcomes.

A systematic review was performed on published studies identified by the databases PubMed, EMBASE, the China Biological Medicine Datadase (CBMdisc), Ovid and the Cochrane Library, as well as cross-references. Randomized controlled trials on laparoscopic versus open myomectomy were assessed on operative parameters and outcomes. Six studies and 576 patients were studied. Analysis was performed using the statistical software Review Manager Version 4.2. The data available show that laparoscopic myomectomy was associated with less hemoglobin drop, reduced operative blood loss, more patients fully recuperated at day 15, diminished postoperative pain, and fewer overall complications but longer operation time. However, major complications, pregnancy and recurrence were comparable in the two groups.

The data show that if performed by suitably specialized surgeons in selected patients, laparoscopic myomectomy is a better choice than open surgery.

Keywords: Laparoscopic, Open, Myomectomy, Meta-analysis