European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 145, Issue 1 , Pages 22-26 , July 2009

Circulating microparticles, lupus anticoagulant and recurrent miscarriages

  • Jaume Alijotas-Reig

      Affiliations

    • Ageing & Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Vall d’Hebron University Hospital, Paseo Vall d’hebron 125-135, Faculty of Medicine, Universitat Autonoma, Barcelona, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 93 4894194; fax: +34 93 2607617.
    • ,
  • Carles Palacio-Garcia

      Affiliations

    • Flow Cytometry Unit, Haematology Service, Vall d’Hebron University Hospital, Universitat Autonoma, Barcelona, Spain
    • ,
  • Miquel Vilardell-Tarres

      Affiliations

    • Ageing & Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Vall d’Hebron University Hospital, Paseo Vall d’hebron 125-135, Faculty of Medicine, Universitat Autonoma, Barcelona, Spain

Received 5 August 2008 ,Revised 9 March 2009 ,Accepted 1 April 2009.

References 

  1. Alijotas-Reig J, Ferrer-Raventos JC. Recurrent miscarriage and inherited thrombophilia: diagnostic work-out and therapeutic management. Med Clin (Barc). 2005;125:626–631
  2. Greer IA. Thrombosis in pregnancy: maternal and fetal issues. Lancet. 1999;353:1258–1265
  3. Coulam CB. Epidemiology of recurrent spontaneous abortion. Am J Reprod Immunol. 1991;26:23–27
  4. Coulam CB, Faulk WP, McIntyre JA. Immunotherapy for recurrent spontaneous abortion and its analogies to treatment for cancer. Am J Reprod Immunol. 1991;25:114–119
  5. Taylor RN, de Groot C, Cho YK, Lim HK. Circulating factors as markers and mediators of endothelial cell dysfunction in preeclampsia. Semin Repord Endocrinol. 1998;16:17–31
  6. Meroni PL. Endothelial cell perturbation by anti-phospholipid antibodies in systemic lupus erythematosus. Lupus. 2007;16(Suppl.):17–19
  7. Meroni PL, Borghi MO, Raschi E, et al. Inflammatory response and the endothelium. Thromb Res. 2004;114:329–334
  8. Roubay RA. Tissue factor pathway and the antiphospholipid syndrome. J Autoimmun. 2000;15:217–220
  9. Kaplasnki G, Cacoub P, Farnarier C, et al. Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosus-related antiphospholipid syndrome: correlations with severity of thrombosis. Arthritis Rheum. 2000;43:55–64
  10. Meroni PL, Riboldi P. Pathogenic mechanisms of antiphospholipid syndrome: a new autoimmune disease. Drug Disc Today: Dis Mech. 2004;1:309–314
  11. Distler JH, Pisetsky DS, Huber L, Kalden JR, Gay S, Distler O. Microparticles as regulators of inflammation. Arthritis Rheum. 2005;52:3337–3348
  12. Wolf P. The nature and significance of platelet products in human plasma. Br J Haematol. 1967;13:269–288
  13. Germain ASJ, Sacks GP, Soorana S, Sargent IL, Redman CW. Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotophoblast microparticles. J Immunol. 2007;178:5949–5956
  14. Hamilton KK, Hattori R, Esmon CT, Sims PJ. Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex. J Biol Chem. 1990;265:3809–3814
  15. Hristov M, Erl W, Linder S, Weber PC. Apoptotic bodies from endothelial cells enhanced the number and initiate the differentiation of human endothelial progenitor cells in vitro. Blood. 2004;104:2761–2766
  16. Denzer K, van Eijk M, Kleijmeer MJ, Jakobson E, de Groot C, Geuze HJ. Follicular dendritic cells carry MHC class-II-expressing microvesicles at their surface. J Immunol. 2000;165:1259–1265
  17. Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, Geuze HJ. Exosome: from internal vesicle of the multivesicular body to intercellular signalling device. J Cell Sci. 2000;113:3365–3374
  18. Fourcade O, Simon MF, Viode C, et al. Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell. 1995;80:919–927
  19. Brogan PA, Shah V, Brachet C, et al. Endothelial and platelet microparticles in vascultis of the young. Arthritis Rheum. 2004;50:927–936
  20. Distler JH, Huber LC, Reich CF, Gay S, Distler O, Pisetsky DS. The release of microparticles by apoptoticcells and their effects on macrophages. Apoptosis. 2005;
  21. Butikofer P, Kuypers FA, Xu CM, Chiu DT, Lubin B. Enrichment of two glyosyl-phosphatidylinositol-anchored proteins, acetylcholinenesterase and decay accelerating factor, in vesicles released from human red blood cells. Blood. 1989;74:1481–1485
  22. Salzer U, Hinterdorfer P, Hunger P, Borken C, Prohaska R. Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin. Blood. 2002;99:2569–2577
  23. Jy W, Horstman LL, Jimenez JJ, Ahn YS. Measuring circulating cell-derived microparticles. J Thromb Haemost. 2004;2:1842–1843
  24. Kupferminc MJ, Eldor A. Inherited thrombophilia and gestational vascular complications. Semin Thromb Haemost. 2003;29:185–193
  25. Infante-Rivard C, David M, Gauthier R, Rivard GE. Lupus anticoagulants, anticardiolipin antibodies, and fetal loss: a case–control study. N Engl J Med. 1991;325:1063–1066
  26. Branch WR, Khamashta MA. Antiphospholpid syndrome: obstetric diagnosis, management, and controversies. Obstet Gynecol. 2003;101:1333–1448
  27. Alijotas J. Towards the understanding of heterogeneity of clinical manifestations related to antiphospholipid antibodies. Med Clin (Barc). 2005;125:187–189
  28. Laude I, Rongieres C, Boyer C, et al. Circulating procoagulant microparticles in women with unexplained pregnancy loss: a new insight. Thromb Haemost. 2001;85:18–21
  29. Bevers EM, Comfurius P, Dekkers DW, Harmsma M, Zwaal RF. Trnasmembrane phospholipids distribution in blood cells: control mechanism and pathophysiological significance. J Biol Chem. 1998;379:973–986
  30. Barry OP, Practico D, Lawson JA, Fitzgerald GA. Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. J Clin Invest. 1997;99:2118–2127
  31. Mesri M, Altieri DC. Endothelial cell activation by leukocyte microparticles. J Immunol. 1998;16:4382–4387
  32. Mallat Z, Benamer H, Hugel JM, et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation. 2000;101:841–848
  33. Galli M, Grassi I, Barbui T. Platelet-derived microvesicles in thrombotic thrombocytopenic purpura and haemolytic uremic syndromes. Thromb Haemost. 1996;75:427–431
  34. Jimenez JJ, Jy W, Mauro LM, Hortsman LL, Ahn YS. Elevated endothelial microparticles in thrombotic trombocitopenic purpura: findings from brain and renal mirovascular cell culture and patients with active disease. Br J Haematol. 2001;112:81–90
  35. Joop K, Nieuwland R, Berrckmans RJ, et al. Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanism. Thromb Haemost. 2001;85:810–820
  36. Minagar A, Jimenez JJ, Jy W, et al. Elevated plasma endothelial microparticles in multiple sclerosis. Neurology. 2001;56:1319–1324
  37. Bretelle F, Sabatier F, Desprez D, et al. Circulating microparticles: a marker of procoagulant state in normal pregnancy and pregnancy complicated by preeclampsia or intra uterine growth restriction. Thromb Haemost. 2003;89:486–492
  38. Carp H, Dardik R, Lubetsky A, et al. Prevalence of circulating procoagulant microparticles in women with recurrent miscarriage: a case-controlled study. Hum Reprod. 2004;19:191–195
  39. Combes B, Simon AC, Grau GE, et al. In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant. J Clin Invest. 1999;104:93–102
  40. Omatsu K, Kobayashi T, Murakami Y, et al. Phophatidylserine/phosphatidylcholine microvesicles can induce pre-eclampsia-like changes in pregnant mice. Semin Thromb Haemost. 2005;31:314–320
  41. Van Wijk MJ, Svedas E, Boer K, Nieuwland R, Vanbavel E, Kublickiene KR. Isolated microparticles, but not whole plasma, from women with preeclampsia impair entothelium-dependent relaxation in isolated myometrial arteries from healthy pregnant women. Am J Obstet Gyneol. 2002;187
  42. Greer IA. Endothelial cell microparticles and antiphospholipid syndrome: pathologic explanations and diagnostic opportunities. Thromb Haemost. 2004;91:636–638
  43. Dignat-George F, Camoin L, Sabatier F, et al. Endothelial microparticles: a potential contribution to the thrombotic complications of the antiphospholipid syndrome. Thromb Haemost. 2004;91:667–673
  44. D’Cruz D, Hughes G. Antibodies, thrombosis and the endothelium. Br J Rheumatol. 1996;33:2–5
  45. Galli M, Luciani D, Bertolini G, Barbui T. Lupus anticoagulants are stronger risk factors of thrombosis than anticardiolipina antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood. 2003;101:1827–1832
  46. Beutler B, Bazzoni F. TNF, apoptosis and autoimmunity a common threat?. Blood Cells Mol Dis. 1998;24:216–230
  47. Chironi GN, Boulanger CM, Simon A, Dignat-George F, Freyssenet JM, Tedgui A. Endothelial microparticles in disease. Cell Tissue Res. 2009;335:143–151
  48. Jy W, Tiede M, Bidot CJ, Hortsmann LL, Jiménez JJ, Chirinos J. Platelet activation rather than endothelial injury identifies risk of thrombosis in subjects positive for antiphiospholipid antibodies. Thromb Res. 2007;121:319–325
  49. Pereira J, Alfaro G, Goycoolea M, et al. Circulating platelet-derived microparticles in systemic lupus erythematosus Association with increased thrombin generation and procoagulant state. Thromb Haemost. 2006;95:94–99
  50. Toth B, Niewland R, Kern M, et al. Systemic changes in haemostatic balance are not associated with increased levels of circulating microparticles in women with recurrent spontaneous abortion. Am J Reprod Immunol. 2008;59:159–166

PII: S0301-2115(09)00246-2

doi: 10.1016/j.ejogrb.2009.04.002

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 145, Issue 1 , Pages 22-26 , July 2009

Article Tools