European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 146, Issue 2 , Pages 188-192 , October 2009

The effects of topical isoflavones on postmenopausal skin: Double-blind and randomized clinical trial of efficacy

  • Andrea B. Moraes

      Affiliations

    • Division of Endocrinology Gynecology – Department of Gynecology – UNIFESP, Brazil
    • ,
  • Mauro A. Haidar

      Affiliations

    • Division of Endocrinology Gynecology – Department of Gynecology – UNIFESP, Brazil
    • ,
  • José Maria Soares Júnior

      Affiliations

    • Division of Endocrinology Gynecology – Department of Gynecology – UNIFESP, Brazil
    • Corresponding Author InformationCorresponding author at: Rua Sena Madureira 1245 apt 11, 04021051 – São Paulo, SP, Brazil. Tel.: +55 11 5 813685; fax: +55 11 5 813685.
    • ,
  • Manuel J. Simões

      Affiliations

    • Department of Morphology – UNIFESP, Brazil
    • ,
  • Edmund C. Baracat

      Affiliations

    • Departamento de Obstetrícia e Ginecologia da Faculdade de Medicina da Universidade de São Paulo, Brazil
    • ,
  • Marisa T. Patriarca

      Affiliations

    • Division of Endocrinology Gynecology – Department of Gynecology – UNIFESP, Brazil

Received 3 September 2008 ,Revised 27 February 2009 ,Accepted 7 April 2009.

References 

  1. Castelo-Branco C, Pons F, Gratacos E, et al. Relationship between skin collagen and bone changes during aging. Maturitas. 1994;18:199–206
  2. Brincat M, Moniz CF, Studd JWW, et al. Sex hormones and skin collagen content in postmenopausal women. Br Med J. 1993;287:1337–1338
  3. Holzer G, Riegler E, Honigsmann H, et al. Effects and side-effects of 2% progesterone cream on the skin of peri- and postmenopausal women: results from a double-blind, vehicle-controlled, randomized study. Br J Dermatol. 2005;153:626–634
  4. Haapasaari KM, Raudaskoski T, Kallionen M, et al. Systemic therapy with estrogen or estrogen with progestin has no effect on skin collagen in postmenopausal women. Maturitas. 1997;27(2):153–162
  5. Oikarinen A. Systemic estrogens have no conclusive beneficial effect on human skin connective tissue. Acta Obstet Gyencol Scand. 2000;79:250–254
  6. Schmidt JB, Bender M, Demschi K, et al. Treatment of skin aging with topical estrogens. Int J Dermatol. 1994;35(9):669–674
  7. Varila E, Rantala I, Oikarinen A, et al. The effect of topical estradiol on skin collagen of postmenopausal women. Br J Obstet Gynecol. 1995;102:985–989
  8. Patriarca MT, Goldman KZ, Dos Santos JM, et al. Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2007;130:202–205
  9. Vérdier-Sévrain S, Bonté F, Gilchrest B. Biology of estrogens in skin: implications for skin aging. Exp Dermatol. 2006;15:83–94
  10. Wolff EF, Narayan D, Taylor HS. Long-term effects of hormone therapy on skin rigidity and wrinkles. Fertil Steril. 2005;84:285–588
  11. Naftolin F. Prevention during the menopause is critical for good health: skin studies support protacted hormone therapy. Fertil Steril. 2005;84:293–294
  12. Zouboulis CC, Chen WC, Thornton MJ, Qin K, Rosenfield R. Sexual hormones in human skin. Horm Metab Res. 2007;39:85–95
  13. Nachtigall LE, Nachtigall MJ. Menopausal changes, quality of life, and therapy. Clin Obstet Gynecol. 2004;47:485–488
  14. Mosquette R, Simões MJ, da Silva ID, et al. The effects of soy extract on the uterus of castrated adult rats. Maturitas. 2007;56:173–183
  15. Setchell KD, Brown NM, Desai P, et al. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr. 2001;131:1362S–2175S
  16. Kessel B. Alternatives to estrogen for menopausal women. Proc Soc Exp Biol Med. 1998;217:38–44
  17. Bayerl C, Keil D. Isoflavanoide in der Behandlung der Hautalterung postmenopausaler Frauen. Akt Dermatol. 2002;28:14–18
  18. Izumi T, Saito M, Obata A, Masayuki AR, Yamaguchi H, Matsuyama A. Oral intake of soy isoflavone aglycone improves the aged skin of adult women. J. Nutr Sci Vitaminol. 2007;53:57–62
  19. Circosta C, De Pasquale R, Palumbo DR, Sampieri S, Occhiuto F. Effects of isoflavones from red clover (Trifolium pretense) on skin changes induced by ovariectomy in rats. Phitother Res. 2006;20(12):1096–1099
  20. Galhardo CL, Soares JM, Simões RS, Haidar MA, Rodrigues de Lima G, Baracat EC. Estrogen effects on the vaginal pH, flora and cytology in late postmenopause after a long period without hormone therapy. Clin Exp Obstet Gynecol. 2006;33:85–89
  21. Fuchs KO, Solis O, Tapawan R, Paranjpe J. The effects of no estrogen and glycolic acid cream on tue facial skin of postmenopausal women: a randomized histologyc study. Cutis. 2003;71:481–488
  22. Schmidt JB, Binder M, Macheiner W, Kainz C, Gitsch G, Beilmayer C. Treatment of skin aging symptoms in perimenopausal females with estrogen compounds. Maturitas. 1994;20:25–30
  23. Credi P, Faivre B, Agache P, Richard E, Haudiquet V, Sauvanet JP. Effect of a conjugated oestrogen cream on ageing facial skin. A comparative study with placebo cream. Maturitas. 1994;19:211–223
  24. Kanda N, Watanabe S. 17 beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression. J Invest Dermatol. 2004;123:319–328
  25. Kanda N, Watanabe S. 17 beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression. J Invest Dermatol. 2003;121:1500–1509
  26. Haczynski J, Tarkowski R, Jarzabek K. Human cultured skin fibroblasts express estrogen receptor alpha and beta. Int J Mol Med. 2002;10:149–153
  27. Ashcroft GS, Dodsworth J, Van Boxtel E, Tarnuzzer RW, Horan MA, Schultz GS. Estrogen accelerates cutaneous bound healing associated with an increase in TGFbeta 1 levels. Nat Med. 1997;11:1209–1215
  28. Rondon AS, da Silva LP, Simões RS, Mosquette R, Soares JM, Simões MJ. Efeitos da radiação ultravioleta na pele. RBM. 2005;62:127–130
  29. Kang S, Chung JH, Lee JH, Fisher GJ, Wan YS, Duell EA. Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo. J Invest Dermatol. 2003;120:835–841
  30. Kaari C, Haidar MA, Soares JM, et al. Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study. Maturitas. 2006;53:49–58

PII: S0301-2115(09)00255-3

doi: 10.1016/j.ejogrb.2009.04.007

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 146, Issue 2 , Pages 188-192 , October 2009

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