European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 146, Issue 2 , Pages 165-168 , October 2009

Assessment of the female fetal DNA concentration in the plasma of the pregnant women as preeclampsia indicator—Preliminary report

  • Engel Karina

      Affiliations

    • Department of Feto-Maternal Medicine, Pomeranian Medical University, 1 Unii Lubelskiej Street, 71-252 Szczecin, Poland
    • ,
  • Płonka Tomasz

      Affiliations

    • Department of Feto-Maternal Medicine, Pomeranian Medical University, 1 Unii Lubelskiej Street, 71-252 Szczecin, Poland
    • ,
  • Marek Bilar

      Affiliations

    • Department of Feto-Maternal Medicine, Pomeranian Medical University, 1 Unii Lubelskiej Street, 71-252 Szczecin, Poland
    • Corresponding Author InformationCorresponding author. Tel.: +48 91 425 3292; fax: +48 91 425 33 09.
    • ,
  • Orzińska Agnieszka

      Affiliations

    • Department of Immunohematology and Immunology of Transfusion Medicine, Institute of Hematology and Transfusion Medicine, 14 Gandhi Street, 02-776 Warsaw, Poland
    • ,
  • Brojer Ewa

      Affiliations

    • Department of Immunohematology and Immunology of Transfusion Medicine, Institute of Hematology and Transfusion Medicine, 14 Gandhi Street, 02-776 Warsaw, Poland
    • ,
  • Ronin-Walkowska Elżbieta

      Affiliations

    • Department of Feto-Maternal Medicine, Pomeranian Medical University, 1 Unii Lubelskiej Street, 71-252 Szczecin, Poland

Received 22 January 2009 ,Revised 26 April 2009 ,Accepted 15 June 2009.

References 

  1. Krabchi NC, Gadji M, Samassekou O, Gregoire MC, Forest JC, Drouin R. Quantification of fetal nucleated cells in maternal blood of pregnant women with a male trisomy 21 fetus using molecular cytogenetic techniques. Prenat Diagn. 2006;26:145–150
  2. Lo YM, Tein MSC, Lau TK, et al. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet. 1998;62:768–775
  3. Chen C-P, Chern S-R, Wang W. Fetal DNA analyzed in plasma from a mothers three consecutive pregnancies to detect paternally inherited aneuploidy. Clin Chem. 2001;47:937–939
  4. Lo YM, Lau TK, Chan LY, Leung TN, Chang AM. Quantitative analysis of the bidirectional fetomaternal transfer of nucleated cells and plasma DNA. Clin Chem. 2000;46:1301–1309
  5. Shimada K, Murakami K, Shozu M, Segawa T, Sumtani H, Inoue M. Sex determining region Y levels in maternal plasma: evaluation in abnormal pregnancy. J Obstet Gynecol Res. 2004;30:148–154
  6. Lo YMD, Zhang J, Leung TN, Lau TK, Chang AM, Hjelm NM. Rapid clearance of fetal DNA from maternal plasma. Am J Hum Genet. 1999;64:232–234
  7. Hahn S, Holzgreve W. Fetal cells and cell-free fetal DNA in maternal blood: new insights into preeclmpsia. Hum Reprod Update. 2002;8:501–508
  8. Hahn S, Huppertz B, Holzgreve W. Fetal cells and cell free fetal nucleic acids in maternal blood: new tools to study abnormal placentation?. Placenta. 2005;26:515–526
  9. Wong BC, Lo YM. Cell-free DNA and RNA in plasma as new tools for molecular diagnostics. Expert Rev Mol Diagn. 2003;3:785–797
  10. Costa JM, Giovangrandi Y, Ernault P, et al. Fetal RhD genotyping in maternal serum during the first trimester of pregnancy. Br J Haematol. 2002;119:255–260
  11. Hromadnicova I, Vechetova L, Vesela K, et al. Non-invasive fetal RHD exon 7 and exon 10 genotyping using real-time PCR testing of fetal DNA in maternal plasma. Fetal Diagn Ther. 2005;20:275–280
  12. Legler T, Lynen R, Maas J, et al. Prediction of fetal Rh D and Rh CcEe phenotype from maternal plasma with real-time polymerase chain reaction. Transfus Apheresis Sci. 2002;27:217–223
  13. Chiu RW, Lau TK, Cheung PT, Gong ZQ, Leung TN, Lo YM. Noninvasise prenatal exclusion of congenital adrenal hyperplasia by maternal plasma analysis: a feasibility study. Clin Chem. 2002;48:778–780
  14. Li Y, Holzgreve W, Page-Chrisianens GC, Gille JJ, Hahn S. Improved prenatal detection of a fetal point mutation for achondroplasia by use of size-fractionated circulatory DNA in maternal plasma—case report. Prenat Diagn. 2004;24:896–898
  15. Bischoff FZ, Sinacori MK, Dang DD, et al. Cell-free fetal DNA and intact fetal cells in maternal blood circulation: implication for first and second trimester non-invasive prenatal diagnosis. Hum Reprod Update. 2002;8:493–500
  16. Levine RJ, Qian C, Leshane ES, et al. Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia. Am J Obstet Gynecol. 2004;190:707–713
  17. Engel K, Plonka T, Bilar M, Orzinska A, Brojer E, Ronin-Walknowska E. The correlation between clinical characteristics of preeclampsia and the concentration of fetal DNA in maternal circulation. Eur J Obstet Gynecol. 2008;139:256–260
  18. Lo YMD, Leung TN, Tein MS, et al. Quantitative abnormalities of fetal DNA in maternal serum in pre-eclampsia. Clin Chem. 1999;45:184–188
  19. Swinkels DW, de Kok JB, Hendriks JC, Wigerinck E, Zusterzeel PLM, Steegers EA. Haemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome as a complication of preeclampsia in pregnant women increases the amount of cell-free fetal and maternal plasma and serum. Clin Chem. 2002;48:650–653
  20. Brojer E, Żupanska B, Guz K, Orzinska A, Kalinska A. Noninvasive determination of fetal RhD status by examination of cell-free DNA in maternal plasma. Transfusion. 2005;45:1473–1480
  21. Alizadeh M, Bernard M, Danic B, et al. Quantitative assessment of hematopoietic chimerism after bone marrow transplantation by real time quantitative polymerase chain reaction. Blood. 2002;99:4618–4625
  22. Smid M, Vassalo A, Lagona F, et al. Quantitative analysis of fetal DNA in maternal plasma in pathological conditions associated with placental abnormalities. Ann NY Acad Sci. 2001;945:132–137
  23. Zhong XY, Burk MR, Troeger C, et al. Fluctuation of maternal and fetal free extracellular circulatory DNA in maternal plasma. Obstet Gynecol. 2000;96:991–996
  24. Zhong XY, Laivuori H, Livingston JC, et al. Elevation of both maternal and fetal extracellular circulating deoxyribonucleic amid concentrations in the plasma of pregnant women with preeclampsia. Am J Obstet Gynecol. 2001;184:414–419

PII: S0301-2115(09)00420-5

doi: 10.1016/j.ejogrb.2009.06.016

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 146, Issue 2 , Pages 165-168 , October 2009

Article Tools