European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 147, Issue 2 , Pages 166-172 , December 2009

Evaluation of the tocolytic effect of morphine in a mouse model of lipopolysaccharide-induced preterm delivery: The role of nitric oxide

  • Mehrak Javadi-Paydar

      Affiliations

    • Brain and Spinal Injury Repair Research Center, Imam Khomeini Hospital, Tehran, Iran
    • Basic Medical Sciences Research Center, Imam Khomeini Hospital, Tehran, Iran
  • ,
  • Ali Lesani

      Affiliations

    • Basic Medical Sciences Research Center, Imam Khomeini Hospital, Tehran, Iran
    • Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran
  • ,
  • Ramin Vakilipour

      Affiliations

    • Basic Medical Sciences Research Center, Imam Khomeini Hospital, Tehran, Iran
  • ,
  • Payam Ghazi

      Affiliations

    • Basic Medical Sciences Research Center, Imam Khomeini Hospital, Tehran, Iran
  • ,
  • Seyed Mohammad Tavangar

      Affiliations

    • Department of Pathology/Endocrinology & Metabolism Research Center, Shariati Hospital, Tehran, Iran
  • ,
  • Sedigheh Hantoushzadeh

      Affiliations

    • Vali-e-Asr Reproductive Health Research Center, Vali-e-Asr Hospital, Tehran, Iran
  • ,
  • Abbas Norouzi

      Affiliations

    • Brain and Spinal Injury Repair Research Center, Imam Khomeini Hospital, Tehran, Iran
    • Vali-e-Asr Reproductive Health Research Center, Vali-e-Asr Hospital, Tehran, Iran
  • ,
  • Ahmad Reza Dehpour

      Affiliations

    • Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran
    • Corresponding Author InformationCorresponding author. Tel.: +98 21 66402569; fax: +98 21 66402569.

Received 31 December 2008 ,Revised 29 April 2009 ,Accepted 19 August 2009.

References 

  1. Holmgren C, Esplin MS, Hamblin S, Molenda M, Simonsen S, Silver R. Evaluation of the use of anti-TNF-α in an LPS-induced murine model. J Reprod Immunol. 2008;78:134–139
  2. Kaga N, Katsuki Y, Kajikawa S, Shibutani Y. Preventive effect of ritodrine hydrochloride and/or urinary trypsin inhibitor against lipopolysaccharide-induced preterm delivery in mice. Acta Obstet Gynecol Scand. 1997;76:811–816
  3. Romero R, Mazor M. Infection and preterm labor. Clin Obstet Gynecol. 1988;31(3):553–584
  4. Xu DX, Chen YH, Wang H, Zhao L, Wang JP, Wei W. Effect of N-acetylcysteine on lipopolysaccharide induced intra uterine fetal death and intra uterine growth retardation in mice. Toxicol Sci. 2005;88:525–533
  5. Xu DX, Chen YH, Wang H, Zhao L, Wang JP, Wei W. Tumor necrosis factor alpha partially contributes to lipopolysaccharide induced intra uterine fetal growth restriction and skeletal development retardation in mice. Toxicol Lett. 2006;163:20–29
  6. Kajikawa S, Kaga N, Futamura Y, Kakinuma C, Shibutani Y. Lipotheichoic acid induces preterm delivery in mice. J Pharmacol Toxical Methods. 1998;39:147–154
  7. Xu DX, Wang H, Zhao L, Ning H, Zhang C, Chen YH. Effects of low dose lipopolysccharid (LPS) pretreatment on LPS-induced intra-uterine fetal death and preterm labor. Toxicology. 2007;234:167–175
  8. Fidel PL, Romero R, Wolf N, et al. Systemic and local cytokine profiles in endotoxin-induced preterm parturition in mice. Am J Obstet Gynecol. 1994;170:1467–1475
  9. Gravett MG, Witkin SS, Haluska GJ, Edwards JL, Cook MJ, Novy MJ. An experimental model for intraamniotic infection and preterm labor in rhesus monkey. Am J Obstet Gynecol. 1994;171:1660–1667
  10. Zhu Y, Paintar JE. Expression of opioid receptor and ligands in pregnant mouse uterus and placenta. Biol Reprod. 1998;59:925–932
  11. Moncada SR, Palmer MG, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 1995;43:109–142
  12. Bricker L, Lavender T. Parenteral opioida for labor pain relief: a systemic review. Am J Obstet Gynecol. 2002;186:S94–109
  13. Yallampalli C, Garfield RE, Byan-Smith M. Nitric oxide inhibits uterine contractility during pregnancy but not during delivery. Endocrinol. 1993;133:1899–1902
  14. Helmbrecht GD, Farhat MY, Lochbaum L, et al. l-Arginine reverse the adverse pregnancy changes induced by nitric oxide synthase inhibition in the rat. Am J Obstet Gynecol. 1996;175:800–805
  15. Yallampalli C, Burnmscrn I, Chwalisz K, Garfield RE, Dong YL. Preterm birth in rats produced by the synergistic action of a nitric oxide inhibitor (NG-nitro-targinine methyl ester) and an antiprogestin (onapristone). Am J Obstet Gynecol. 1996;175:207–212
  16. Tiboni GM, Glampietro F. Inhibition of nitric oxide synthesis causes preterm delivery in the mouse. Hum Reprod. 2000;15:1838–1842
  17. Welters ID, Menzebach A, Goumon Y, et al. Morphine inhibits NF-KB nuclear binding in human nutrophils and monocytes by a nitric oxide dependent mechanism. Anesthesiology. 2000;92:1677–1684
  18. Magazine HI, Liu Y, Bilfinger TV, Fricchione GL, Stefano GB. Morphine-induced conformational changes in human monocytes, granulocytes and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. J Immunol. 1996;156:4845–4850
  19. Kaga N, Katsuki Y, Obata M, Shibutani Y. Repeated administration of low-dose lipopolysaccharide induces preterm delivery in mice: a model for human preterm parturition and for assessment of the therapeutic ability of drugs against preterm delivery. Am J Ostet Gynecol. 1996;174:754–759
  20. de Pace V, Chiossi G, Facchinetti F. Clinical use of nitric oxide donors and l-arginine in obstetrics. J Matern Fetal Neonatal Med. 2007;20(8):569–579[Review]
  21. Marinoni E, Di Iorio R, Villaccio B, Alberini A, Rota F, Cosmi EV. Amniotic fluid nitric oxide metabolite levels and nitric oxide synthase localization in feto-placental tissues are modified in association with human labor. Eur J Obstet Gynecol Reprod Biol. 2000;89:47–54
  22. Kelly NM, Cross AS. Interlukin-6 is a better marker of lethality than tumor necrosis factor in endotoxin treated mice. FEMS Microbiol Immunol. 1992;89:317–322
  23. Ogando DG, Paz D, Cella M, Franchi AM. The fundamental role of increased production of nitric oxide in lipopolysaccharide-induced embryonic resorption in mice. Reproduction. 2003;125:95–110
  24. Athanassakis I, Aifantis I, Ranella A, Giouremou K, Vassiliadis S. Inhibition of nitric oxide production rescues LPS-induced fetal abortion in mice. Nitric Oxide. 1999;3:216–224
  25. Weber NC, Kandler J, Schlack W, Grueber Y, Frabdorf J, Preckel B. Intermitted pharmacologic pretreatment by xenon, isoflurane, nitrous oxide and the opioid morphine prevents tumor necrosis factor alpha induced adhesion molecule expression in human umbilical vein endothelial cells. Anesthesiology. 2008;108:199–207
  26. Santolaya-Forgas J, Romero R, Mehendale R. The effect of continuous morphine administration on maternal plasma oxytocin concentration and uterine contractions after open fetal surgery. J Maternal-Fetal Neonatal Med. 2006;19(4):231–238
  27. Fimiani C, Mattocks D, Cavani F, et al. Morphine and anandamide stimulate intracellular calcium transient in human arterial endothelial cells: coupling to nitric oxide release. Cell Signal. 1999;11:189–193
  28. Tseng L, Mazella J, Goligorsky MS, Rialas CM, Stefano GB. Dopamine and morphine stimulate nitric oxide release in human endometrial glandular epithelial cells. J Soc Gynecol Investig. 2000;7(6):343–347
  29. McKay DG, Wong TC. The effect of bacterial endotoxin on the placenta of the rat. Am J Pathol. 1963;42:357–377
  30. Russell JA, Gosden RG, Humphreys EM, et al. Interruption of parturition in rats by morphine: a result of inhibition of oxytocin secretion. J Endocrinol. 1989;121(3):521–536
  31. Russell JA, Leng G, Coombes JE, et al. Pethidine (meperidine) inhibition of oxytocin secretion and action in parturient rats. Am J Physiol. 1991;261:R358–R368

PII: S0301-2115(09)00503-X

doi: 10.1016/j.ejogrb.2009.08.014

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 147, Issue 2 , Pages 166-172 , December 2009