European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 147, Issue 2 , Pages 192-194 , December 2009

Effects of strontium ranelate, raloxifene and misoprostol on bone mineral density in ovariectomized rats

  • Nefise Ahmet-Camcioglu

      Affiliations

    • Department of Obstetrics and Gynecology, Trakya University, Faculty of Medicine, 22030 Edirne, Turkey
    • ,
  • Tulay Okman-Kilic

      Affiliations

    • Department of Obstetrics and Gynecology, Trakya University, Faculty of Medicine, 22030 Edirne, Turkey
    • Corresponding Author InformationCorresponding author at: Kocasinan Mah. Sadik Ahmet Cad., 26. Sok. Celik 26 Beyazsaray Ap. Kat: 2/2, 22030 Edirne, Turkey. Tel.: +90 284 235 76 41; fax: +90 284 235 76 52.
    • ,
  • Gulay Durmus-Altun

      Affiliations

    • Department of Nuclear Medicine, Trakya University, Faculty of Medicine, 22030 Edirne, Turkey
    • ,
  • Galip Ekuklu

      Affiliations

    • Department of Public Health, Trakya University, Faculty of Medicine, 22030 Edirne, Turkey
    • ,
  • Mustafa Kucuk

      Affiliations

    • Department of Obstetrics and Gynecology, Trakya University, Faculty of Medicine, 22030 Edirne, Turkey

Received 9 January 2009 ,Revised 27 August 2009 ,Accepted 7 September 2009.

References 

  1. Castelo-Branco C, Palacios S, Calaf J, Vazquez F, Lanchares JL. Available medical choices for the management of menopause. Maturitas. 2005;52:61–70
  2. Tuck SP, Francis RM. Osteoporosis. Postgraduate Medical Journal. 2002;78:526–532
  3. Weinreb M, Suponitzky I, Keila S. Systemic administration of an anabolic dose of PGE2 in young rats increases the osteogenic capacity of bone marrow. Bone. 1997;20(6):521–526
  4. Yao W, Jee SSW, Zhou H, et al. Anabolic effect of prostaglandin E2 on cortical bone of aged male rats comes mainly from modeling dependent bone gain. Bone. 1999;25(6):697–702
  5. Sonmez AS, Birincioglu M, Özer MK, Kutlu R, Chuong CJ. Effects of misoprostol on bone loss in ovariectomized rats. Prostaglandins and other Lipid Mediators. 1999;57:113–118
  6. Yasar L, Sönmez AS, Utku N, et al. Effect of misoprostol on bone mineral density in women with postmenopausal osteoporosis. Prostaglandins and Other Lipid Mediators. 2006;79:199–205
  7. Seeman E, Eisman JA . Treatment of osteoporosis: why, whom, when and how to treat. MJA. 2004;180(6):298–303
  8. Marie PJ, Hott M, Modrowski D, et al. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. Journal of Bone and Mineral Research. 1993;8(5):607–615
  9. Delannoy P, Bazot D, Marie PJ. Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice. Metabolism. 2002;51(7):906–911
  10. Amman P, Shen V, Robin B, Mauras Y, Bonjour JP, Rizzoli R. Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. Journal of Bone and Mineral Research. 2004;19:2012–2020
  11. Turner CH, Sato M, Bryant HU. Raloxifene preserves bone strength and bone mass in ovariectomized rats. Endocrinology. 1994;136(5):2001–2005
  12. Evans G, Bryant HU, Magee DE. Raloxifene inhibits bone turnover and prevents further cancellous bone loss in adult ovariectomized rats with established osteopenia. Endocrinology. 1996;137(10):4139–4144
  13. Iwamoto J, Yeh JK, Schmidt A, et al. Raloxifene and vitamin K2 combine to improve the femoral neck strength of ovariectomized rats. Calcified Tissue International. 2005;77(2):119–126
  14. Kawaguchi H, Pilbeam CC, Vargas SJ, Morse EE, Lorenzo JA. Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured. Journal of Clinical Investigation. 1995;96:539–548
  15. Rogers A, Clowes JA, Pereda CA, Eastell R. Different effects of raloxifene and estrogene on interleukin-1β and interleukin-1 receptor antagonist production using in vitro and ex vivo studies. Bone. 2007;40:105–110
  16. Mo A, Yao W, Li C, et al. Bipedal stance exercise and prostaglandin E2 (PGE2) and its synergistic effect in increasing bone mass and in lowering the PGE dose required to prevent ovariectomized-induced cancellous bone loss in aged rats. Bone. 2002;31(3):402–406
  17. Iwamoto J, Takeda T, Ichimura S. Effect of administration of lipoprostaglandin E1 on physical activity and bone resorption in patients with neurogenic intermittent claudication. Journal of Orthopaedic Science. 2001;6:242–247
  18. Blake GM, Fogelman I. Theoretical model for the interpretation of BMD scans in patients stopping strontium ranelate treatment. Journal of Bone and Mineral Research. 2006;21(9):1417–1424

PII: S0301-2115(09)00539-9

doi: 10.1016/j.ejogrb.2009.09.001

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 147, Issue 2 , Pages 192-194 , December 2009

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