European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 148, Issue 2 , Pages 144-146 , February 2010

Polymorphisms of FAS and FAS ligand genes in preeclamptic women

  • Pasquapina Ciarmela

      Affiliations

    • Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, Polytechnic University of Marche, via Tronto 10/a, 60020 Ancona, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 0712206270; fax: +39 0712206087.
    • ,
  • Sonia Boschi

      Affiliations

    • Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    • ,
  • Enrrico Bloise

      Affiliations

    • Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    • ,
  • Luca Marozio

      Affiliations

    • Department of Gynecology and Obstetrics, University of Turin, Turin, Italy
    • ,
  • Chiara Benedetto

      Affiliations

    • Department of Gynecology and Obstetrics, University of Turin, Turin, Italy
    • ,
  • Mario Castellucci

      Affiliations

    • Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, Polytechnic University of Marche, via Tronto 10/a, 60020 Ancona, Italy
    • ,
  • Felice Petraglia

      Affiliations

    • Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

Received 3 February 2009 ,Revised 24 June 2009 ,Accepted 20 October 2009.

References 

  1. Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet. 2001;357:53–56
  2. Lain KY, Roberts JM. Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA. 2002;287:3183–3186
  3. Gyongyossy A, Kelentey B. An experimental study of the effect of ischaemia of the pregnant uterus on the blood pressure. J Obstet Gynaecol Br Emp. 1958;65:617–624
  4. Roberts JM. Endothelial dysfunction in preeclampsia. Semin Reprod Endocrinol. 1998;16:5–15
  5. Gervasi MT, Chaiworapongsa T, Pacora P, et al. Phenotypic and metabolic characteristics of monocytes and granulocytes in preeclampsia. Am J Obstet Gynecol. 2001;185:792–797
  6. Knight M, Redman CW, Linton EA, Sargent IL. Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies. Br J Obstet Gynaecol. 1998;105:632–640
  7. DiFederico E, Genbacev O, Fisher SJ. Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am J Pathol. 1999;155:293–301
  8. Burton GJ, Jones CJ. Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta. Taiwan J Obstet Gynecol. 2009;48:28–37
  9. Heazell AE, Crocker IP. Live and let die—regulation of villous trophoblast apoptosis in normal and abnormal pregnancies. Placenta. 2008;29:772–783
  10. Frangsmyr L, Baranov V, Nagaeva O, Stendahl U, Kjellberg L, Mincheva-Nilsson L. Cytoplasmic microvesicular form of Fas ligand in human early placenta: switching the tissue immune privilege hypothesis from cellular to vesicular level. Mol Hum Reprod. 2005;11:35–41
  11. Iannolo G, Conticello C, Memeo L, De Maria R. Apoptosis in normal and cancer stem cells. Crit Rev Oncol Hematol. 2008;66:42–51
  12. Call JA, Eckhardt SG, Camidge DR. Targeted manipulation of apoptosis in cancer treatment. Lancet Oncol. 2008;9:1002–1011
  13. Lorenzo HK, Susin SA. Therapeutic potential of AIF-mediated caspase-independent programmed cell death. Drug Resist Updat. 2007;10:235–255
  14. Mollinedo F, Gajate C. Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy. Drug Resist Updat. 2006;9:51–73
  15. Trauth BC, Klas C, Peters AM, et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science. 1989;245:301–305
  16. Stoneman VE, Bennett MR. Role of Fas/Fas-L in vascular cell apoptosis. J Cardiovasc Pharmacol. 2009;53:100–108
  17. Sziller I, Nguyen D, Halmos A, Hupuczi P, Papp Z, Witkin SS. An A>G polymorphism at position −670 in the Fas (TNFRSF6) gene in pregnant women with pre-eclampsia and intrauterine growth restriction. Mol Hum Reprod. 2005;11:207–210
  18. Wallenburg HC. Prevention of pre-eclampsia: status and perspectives 2000. Eur J Obstet Gynecol Reprod Biol. 2001;94:13–22
  19. Ciarmela P, Florio P, Battistini S, et al. Mutational analysis of the inhibin alpha gene in preeclamptic women. J Endocrinol Invest. 2005;28:30–33
  20. Lahiri DK, Nurnberger JI. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 1991;19:5444
  21. Zhang Z, Shi Q, Sturgis EM, Spitz MR, Hong WK, Wei Q. Thymidylate synthase 5′- and 3′-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck. Clin Cancer Res. 2004;10:7903–7910
  22. Sun T, Miao X, Zhang X, Tan W, Xiong P, Lin D. Polymorphisms of death pathway genes FAS and FASL in esophageal squamous-cell carcinoma. J Natl Cancer Inst. 2004;96:1030–1036
  23. Pinti M, Troiano L, Nasi M, et al. Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: studies on centenarians. Cell Death Differ. 2002;9:431–438
  24. Fleiss J. Statistical methods for rates and proportion. NY: John Wiley and sons; 1981;Chapter 2
  25. Csanyi B, Bogacsi-Szabo E, Tomory G, et al. Y-chromosome analysis of ancient Hungarian and two modern Hungarian-speaking populations from the Carpathian Basin. Ann Hum Genet. 2008;72:519–534
  26. Guglielmino CR, De Silvestri A, Beres J. Probable ancestors of Hungarian ethnic groups: an admixture analysis. Ann Hum Genet. 2000;64:145–159
  27. Tomory G, Csanyi B, Bogacsi-Szabo E, et al. Comparison of maternal lineage and biogeographic analyses of ancient and modern Hungarian populations. Am J Phys Anthropol. 2007;134:354–368
  28. Lai HC, Sytwu HK, Sun CA, et al. Single nucleotide polymorphism at Fas promoter is associated with cervical carcinogenesis. Int J Cancer. 2003;103:221–225
  29. Abrahams VM, Straszewski-Chavez SL, Guller S, Mor G. First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Mol Hum Reprod. 2004;10:55–63
  30. Miko E, Szereday L, Barakonyi A, Jarkovich A, Varga P, Szekeres-Bartho J. Immunoactivation in preeclampsia: Vdelta2+ and regulatory T cells during the inflammatory stage of disease. J Reprod Immunol. 2009;80:100–108

PII: S0301-2115(09)00642-3

doi: 10.1016/j.ejogrb.2009.10.026

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 148, Issue 2 , Pages 144-146 , February 2010

Article Tools