European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 149, Issue 2 , Pages 170-174 , April 2010

Decreased active, total and altered active to total ghrelin ratio in normal weight women with the more severe form of polycystic ovary syndrome

  • Dimitrios Panidis

      Affiliations

    • Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 119, Mitropoleos Str., 54622, Thessaloniki, Greece
    • ,
  • Chrisostomos Asteriadis

      Affiliations

    • Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 119, Mitropoleos Str., 54622, Thessaloniki, Greece
    • ,
  • Neoklis A. Georgopoulos

      Affiliations

    • Division of Reproductive Endocrinology, University of Patras Medical School, Greece
    • Department of Obstetrics and Gynecology, University of Patras Medical School, Greece
    • ,
  • Ilias Katsikis

      Affiliations

    • Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 119, Mitropoleos Str., 54622, Thessaloniki, Greece
    • ,
  • Vassiliki Zournatzi

      Affiliations

    • Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 119, Mitropoleos Str., 54622, Thessaloniki, Greece
    • ,
  • Artemis Karkanaki

      Affiliations

    • Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 119, Mitropoleos Str., 54622, Thessaloniki, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 6932315022; fax: +30 2310 822 509.
    • ,
  • Alexandros D. Saltamavros

      Affiliations

    • Division of Reproductive Endocrinology, University of Patras Medical School, Greece
    • Department of Obstetrics and Gynecology, University of Patras Medical School, Greece
    • ,
  • George Decavalas

      Affiliations

    • Department of Obstetrics and Gynecology, University of Patras Medical School, Greece
    • ,
  • Evanthia Diamanti-Kandarakis

      Affiliations

    • Division of Endocrinology, First Department of Medicine, Laiko Hospital, Medical School, University of Athens, Athens, Greece

Received 9 June 2009 ,Revised 30 October 2009 ,Accepted 21 December 2009.

References 

  1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656–660
  2. Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature. 2001;409:194–198
  3. Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology. 2000;141:4325–4328
  4. Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001;86:5992–5995
  5. Van Der Lely AJ, Tschop M, Heiman M, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004;25:426–457
  6. Shiiya T, Nakazato M, Mizuta M, et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab. 2002;87:240–244
  7. Tschop M, Weyer C, Tataranni PA, Devanaryan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes. 2001;50:707–709
  8. Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41–47
  9. Goodarzi MO, Korenman SG. The importance of insulin resistance in polycystic ovary syndrome. Fertil Steril. 2003;80:255–258
  10. Pagotto U, Gambineri A, Vicennati V, Heiman ML, Tschop M, Pasquali R. Plasma ghrelin, obesity, and the polycystic ovary syndrome, correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab. 2002;87:5625–5629
  11. Schofl C, Horn R, Schill T, Schlosser HW, Muller MJ, Brabant G. Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2002;87:4607–4610
  12. Moran LJ, Noakes M, Clifton PM, et al. Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. J Clin Endocrinol Metab. 2004;89:3337–3344
  13. Mitkov M, Pehlivanov B, Orbetzova M. Serum ghrelin level in women with polycystic ovary syndrome and its relationship with endocrine and metabolic parameters. Gynecol Endocrinol. 2008;24:625–630
  14. Glinborg D, Andersen M, Hagen C, et al. Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS) Adiponectin, ghrelin, leptin and body composition in hirsute Women with PCOS and controls. Eur J Endocrinol. 2006;155:337–345
  15. Wasko R, Komarowska H, Warenik-Szymankiewicz A, Sowinski J. Elevated ghrelin plasma levels in patients with polycystic ovary syndrome. Horm Metab Res. 2004;36:170–173
  16. Panidis D, Farmakiotis D, Koliakos G, et al. Comparative study of plasma ghrelin levels in women with polycystic ovary syndrome, in hyperandrogenic women and in normal controls. Hum Reprod. 2005;20:2127–2132
  17. Zwirska-Korczala K, Sodowski K, Konturek SJ, et al. Postprandial response of ghrelin and PYY and indices of low-grade chronic inflammation in lean young women with polycystic ovary syndrome. J Physiol Pharmacol. 2008;59(Suppl. 2):161–178
  18. Liu J, Prudom CE, Nass R, et al. Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men. J Clin Endocrinol Metab. 2008;93:1980–1987
  19. In:  Zawadski JK,  Dunaif A editor. Polycystic ovary syndrome. Boston: Blackwell Scientific Publications; 1992;
  20. Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet. 2007;370:685–697
  21. Tai MM. A Mathematical model for the determination of total area under glucose tolerance and other metabolic curves. Diabetes Care. 1994;17:152–154
  22. Fernandez-Fernandez R, Tena-Sempere M, Aguilar E, Pinilla L. Ghrelin effects on gonadotropin secretion in male and female rats. Neurosci Lett. 2004;362:103–107
  23. Vulliemoz NR, Xiao E, Xia-Zhang L, Germond M, Rivier J, Ferin M. Decrease in luteinizing hormone pulse frequency during a five hour peripheral ghrelin infusion in the ovariectomized rhesus monkey. J Clin Endocrinol Metab. 2004;89:5718–5723
  24. Barreiro ML, Tena-Sempere M. Ghrelin and reproduction: a novel signal linking energy status and infertility?. Mol Cell Endocrinol. 2004;29:1–9

PII: S0301-2115(09)00741-6

doi: 10.1016/j.ejogrb.2009.12.019

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 149, Issue 2 , Pages 170-174 , April 2010

Article Tools