European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 149, Issue 2 , Pages 178-181 , April 2010

The degree of cycle irregularity correlates with the grade of endocrine and metabolic disorders in PCOS patients

  • Thomas Strowitzki

      Affiliations

    • Dept. of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Voßstraße 9, 69115 Heidelberg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 6221 567910; fax: +49 6221 565356.
  • ,
  • Edison Capp

      Affiliations

    • Dept. of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Voßstraße 9, 69115 Heidelberg, Germany
    • Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Laboratório de Ginecologia e Obstetrícia Molecular, Hospital de Clínicas de Porto Alegre, Brazil
  • ,
  • Helena von Eye Corleta

      Affiliations

    • Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Laboratório de Ginecologia e Obstetrícia Molecular, Hospital de Clínicas de Porto Alegre, Brazil

Received 20 August 2009 ,Revised 7 December 2009 ,Accepted 20 December 2009.

References 

  1. Eisenhardt S, Schwarzmann N, Henschel V, et al. Early effects of metformin in women with polycystic ovary syndrome: a prospective randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab. 2006;91(March (3)):946–952
  2. Lobo RA. What are the key features of importance in polycystic ovary syndrome?. Fertil Steril. 2003;80(August (2)):259–261
  3. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(January (1)):41–47
  4. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev. 1997;18(December (6)):774–800
  5. Baron J. Diagnosis and therapy of hirsutism. Zentralbl Gynakol. 1974;96:129–142
  6. Tai MM. A mathematical model for the determination of total area under glucose tolerance and other metabolic curves. Diabetes Care. 1994;17(February (2)):152–154
  7. Albareda M, Rodriguez-Espinosa J, Murugo M, de Leiva A, Corcoy R. Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia. 2000;43(December (12)):1507–1511
  8. Cussons AJ, Stuckey BG, Walsh JP, Burke V, Norman RJ. Polycystic ovarian syndrome: marked differences between endocrinologists and gynaecologists in diagnosis and management. Clin Endocrinol (Oxf). 2005;62(March (3)):289–295
  9. Polson DW, Adams J, Wadsworth J, Franks S. Polycystic ovaries—a common finding in normal women. Lancet. 1988;1(April (8590)):870–872
  10. Jonard S, Robert Y, Dewailly D. Revisiting the ovarian volume as a diagnostic criterion for polycystic ovaries. Hum Reprod. 2005;20(October (10)):2893–2898
  11. González Centeno A, Nahum Hernández P, Mendoza R, Ayala AR. Correlation between menstruation disorders and insulin resistance. Ginecol Obstet Mex. 2003;71(June):312–317
  12. Castillo-Martínez L, López-Alvarenga JC, Villa AR, González-Barranco J. Menstrual cycle length disorders in 18- to 40-y-old obese women. Nutrition. 2003;19(April (4)):317–320
  13. van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J. Predictive value of menstrual cycle pattern, body mass index, hormone levels and polycystic ovaries at age 15 years for oligo-amenorrhoea at age 18 years. Hum Reprod. 2004;19(February (2)):383–392
  14. Legro RS, Bentley-Lewis R, Driscoll D, Wang SC, Dunaif A. Insulin resistance in the sisters of women with polycystic ovary syndrome: association with hyperandrogenemia rather than menstrual irregularity. J Clin Endocrinol Metab. 2002;87(May (5)):2128–2133
  15. Cupisti S, Kajaia N, Dittrich R, Duezenli H, W Beckmann M, Mueller A. Body mass index and ovarian function are associated with endocrine and metabolic abnormalities in women with hyperandrogenic syndrome. Eur J Endocrinol. 2008;158(May (5)):711–719
  16. van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J. Endocrine features of polycystic ovary syndrome in a random population sample of 14–16 year old adolescents. Hum Reprod. 1999;14(September (9)):2223–2229
  17. Falsetti L, Schivardi MR, Omodei U, Gastaldi A. Polycystic ovary syndrome: long-term evolution. Acta Eur Fertil. 1989;20(May–June (3)):133–136
  18. Chang WY, Knochenhauer ES, Bartolucci AA, Azziz R. Phenotypic spectrum of polycystic ovary syndrome: clinical and biochemical characterization of the three major clinical subgroups. Fertil Steril. 2005;83(June (6)):1717–1723
  19. Behera M, Price T, Walmer D. Estrogenic ovulatory dysfunction or functional female hyperandrogenism: an argument to discard the term polycystic ovary syndrome. Fertil Steril. 2006;86(November (5)):1292–1295
  20. Trivax B, Azziz R. Diagnosis of polycystic ovary syndrome. Clin Obstet Gynecol. 2007;50(March (1)):168–177
  21. Geisthovel F, Rabe T. The ESHRE/ASRM consensus on polycystic ovary syndrome (PCOS)—an extended critical analysis. Reprod Biomed Online. 2007;14(April (4)):522–535
  22. In:  Leidenberger F,  Strowitzki T,  Ortmann O editor. Klinische Endokrinologie für Frauenärzte. Heidelberg: Springer-Verlag; 2009;
  23. Nawroth P, Zorn M, Aulmann M, et al. Leistungsverzeichnis. Zentrallabor Universität Heidelberg; 2009;[accessed 07.10.09] www.klinikum.uni-heidelberg.de/leistungsvezeichnis.7398.0.html

PII: S0301-2115(09)00746-5

doi: 10.1016/j.ejogrb.2009.12.024

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 149, Issue 2 , Pages 178-181 , April 2010