European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 152, Issue 1 , Pages 18-24 , September 2010

Turner syndrome and pregnancy: clinical practice. Recommendations for the management of patients with Turner syndrome before and during pregnancy

  • Laure Cabanes

      Affiliations

    • University Hospital Cochin – Saint-Vincent de Paul, Assistance Publique-Hopitaux de Paris, Université René Descartes, Boulevard de Port Royal, 75005 Paris, France
    • ,
  • Celine Chalas

      Affiliations

    • Biologist Reproductive Medicine, University Hospital Cochin – Saint-Vincent de Paul, Assistance Publique-Hopitaux de Paris, Université René Descartes, Boulevard de Port Royal, 75005 Paris, France
    • ,
  • Sophie Christin-Maitre

      Affiliations

    • Reference Centre for Rare Endocrine Disorders of Growth, University Hospital St Antoine, 184 Rue du Faubourg, Saint Antoine, 75012 Paris, France
    • ,
  • Brun Donadille

      Affiliations

    • Reference Centre for Rare Endocrine Disorders of Growth, University Hospital St Antoine, 184 Rue du Faubourg, Saint Antoine, 75012 Paris, France
    • ,
  • Marie Louise Felten

      Affiliations

    • Hospital Foch, 40 rue Worth, 92150 Suresnes, France
    • ,
  • Valerie Gaxotte

      Affiliations

    • Hospital Foch, 40 rue Worth, 92150 Suresnes, France
    • ,
  • Guillaume Jondeau

      Affiliations

    • Reference Centre for Marfan Syndrome and Related Diseases, University Hospital Bichat, 56 rue Henri Huchard, 7518 Paris, France
    • Appointed by the French Cardiology Society.
    • ,
  • Emmanuel Lansac

      Affiliations

    • Hospital Foch, 40 rue Worth, 92150 Suresnes, France
    • ,
  • Jacques Lansac

      Affiliations

    • French College of Obstetricians and Gynaecologits, 91 Boulevard Sebastopol, 75002 Paris, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 01 43 43 01 00; fax: +33 01 43 43 02 22.
    • ,
  • Hélène Letur

      Affiliations

    • Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 7514 Paris, France
    • Appointed by the French Study Group for Oocyte Donation (GEDO).
    • ,
  • Tatia N’Diaye

      Affiliations

    • University Hospital Jean Bernard, 86000 Poitiers, France
    • ,
  • Jeanine Ohl

      Affiliations

    • Reproductive Medicine Unit, University Hospital, 67000 Strasbourg, France
    • ,
  • Anne Pariente-Khayat

      Affiliations

    • Public Health, Biomedicine Agency, 1 avenue du stade de France, 93212 St Denis la Plaine cedex, France
    • ,
  • Dominique Roulot

      Affiliations

    • University Hospital Avicenne, 125 Route de Stalingrad, 93009 Bobigny, France
    • ,
  • François Thepot

      Affiliations

    • Biologist Reproductive Medicine, Biomedicine Agency, 1 avenue du stade de France, 93212 saint denis la plaine cedex, France
    • ,
  • Delphine Zénaty

      Affiliations

    • Reference Centre for Rare Endocrine Disorders of Growth, University Hospital, Robert Debré 48 Bd Serrurier, 75019 Paris France

Received 5 May 2010 ,Accepted 23 May 2010.

References 

  1. Hovatta O. Pregnancies in women with Turner's syndrome. Ann Med. 1999;31:106–110
  2. Lin AE, Lippe B, Rosenfeld RG. Further delineation of aortic dilation, dissection, and rupture in patients with Turner syndrome. Pediatrics. 1998;102:e12
  3. Mazzanti L, Cacciari E. Congenital heart disease in patients with Turner's syndrome. Italian Study Group for Turner Syndrome (ISGTS). J Pediatr. 1998;133:688–692
  4. Sybert VP. Cardiovascular malformations and complications in Turner syndrome. Pediatrics. 1998;101:E11
  5. Gotzsche CO, Krag-Olsen B, Nielsen J, Sorensen KE, Kristensen BO. Prevalence of cardiovascular malformations and association with karyotypes in Turner's syndrome. Arch Dis Child. 1994;71:433–436
  6. Lippe B. Turner syndrome. Endocrinol Metab Clin North Am. 1991;20:121–152
  7. Delbaere A, Englert Y. Turner's syndrome and oocyte donation. Gynecol Obstet Fertil. 2002;30:970–978
  8. Karnis MF, Zimon AE, Lalwani SI, Timmreck LS, Klipstein S, Reindollar RH. Risk of death in pregnancy achieved through oocyte donation in patients with Turner syndrome: a national survey. Fertil Steril. 2003;80:498–501
  9. Carlson M, Silberbach M. Dissection of the aorta in Turner syndrome: two cases and review of 85 cases in the literature. J Med Genet. 2007;44:745–749
  10. ASMR . Increased maternal cardiovascular mortality associated with pregnancy in women with Turner syndrome. Fertil Steril. 2005;83:1074–1075
  11. ASMR . Increased maternal cardiovascular mortality associated with pregnancy in women with Turner syndrome. Fertil Steril. 2008;90:S185–S186
  12. Floreani A, Molaro M, Baragiotta A, Naccarato R. Chronic cholestasis associated with Turner's syndrome. Digestion. 1999;60:587–589
  13. Roulot D, Degott C, Chazouilleres O, Oberti F, Cales P, Carbonell N, et al. Vascular involvement of the liver in Turner's syndrome. Hepatology. 2004;39:239–247
  14. Albareda MM, Gallego A, Enriquez J, Rodriguez JL, Webb SM. Biochemical liver abnormalities in Turner's syndrome. Eur J Gastroenterol Hepatol. 1999;11:1037–1039
  15. HAS. Syndrome de Turner: protocole national de diagnostic et de soins. 2008:1–53. http://www.has-sante.fr/portail/jcms/c_632797/ald-n-31-syndrome-de-turner.
  16. Immer FF, Bansi AG, Immer-Bansi AS, McDougall J, Zehr KJ, Schaff HV, et al. Aortic dissection in pregnancy: analysis of risk factors and outcome. Ann Thorac Surg. 2003;76:309–314
  17. Matura LA, Ho VB, Rosing DR, Bondy CA. Aortic dilatation and dissection in Turner syndrome. Circulation. 2007;116:1663–1670
  18. Sachdev V, Matura LA, Sidenko S, Ho VB, Arai AE, Rosing DR, et al. Aortic valve disease in Turner syndrome. J Am Coll Cardiol. 2008;51:1904–1909
  19. Pacini L, Digne F, Boumendil A, Muti C, Detaint D, Boileau C, et al. Maternal complication of pregnancy in Marfan syndrome. Int J Cardiol. 2008;
  20. Easterling TR, Benedetti TJ, Schmucker BC, Carlson K, Millard SP. Maternal hemodynamics and aortic diameter in normal and hypertensive pregnancies. Obstet Gynecol. 1991;78:1073–1077
  21. Fenichel P, Letur H. Procreation in Turner's syndrome: which recommendations before, during and after pregnancy?. Gynecol Obstet Fertil. 2008;36:891–897
  22. Letur H, Fenichel P. Hypofertility in Turner's syndrome. Lett Gynecol. 2008;333:16–18
  23. Ostberg JE, Brookes JA, McCarthy C, Halcox J, Conway GS. A comparison of echocardiography and magnetic resonance imaging in cardiovascular screening of adults with Turner syndrome. J Clin Endocrinol Metab. 2004;89:5966–5971
  24. Roman MJ, Devereux RB, Kramer-Fox R, O’Loughlin J. Two-dimensional echocardiographic aortic root dimensions in normal children and adults. Am J Cardiol. 1989;64:507–512
  25. Bondy CA. Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group. J Clin Endocrinol Metab. 2007;92:10–25
  26. Elsheikh M, Casadei B, Conway GS, Wass JA. Hypertension is a major risk factor for aortic root dilatation in women with Turner's syndrome. Clin Endocrinol (Oxf). 2001;54:69–73

☆ On behalf of the joint practice committee of the French College of Obstetricians and Gynaecologists, the French Cardiologic Society, the French Chest and Cardiovascular Surgery Society, the French Society of Anaesthesia and Intensive Care, the French Endocrine Society, the French study group for oocyte donation, and the Biomedicine Agency.

PII: S0301-2115(10)00264-2

doi: 10.1016/j.ejogrb.2010.05.019

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 152, Issue 1 , Pages 18-24 , September 2010

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