European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 152, Issue 1 , Pages 50-54, September 2010

The effects of ritodrine and magnesium sulfate on maternal and fetal Doppler blood flow patterns in women with preterm labor☆☆☆

  • N. Cenk Sayin

      Affiliations

    • Trakya University, Faculty of Medicine, Department of Obstetrics & Gynecology, Edirne, Turkey
    • Corresponding Author InformationCorresponding author at: Trakya Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum A.D., 22030 Edirne, Turkey. Tel.: +90 505 447 26 39; fax: +90 284 235 27 30.
    • ,
  • Sezer Arda

      Affiliations

    • Trakya University, Faculty of Medicine, Department of Obstetrics & Gynecology, Edirne, Turkey
    • ,
  • Füsun G. Varol

      Affiliations

    • Trakya University, Faculty of Medicine, Department of Obstetrics & Gynecology, Edirne, Turkey
    • ,
  • Necdet Süt

      Affiliations

    • Trakya University, Faculty of Medicine, Department of Biostatistics, Edirne, Turkey

Received 16 November 2009; received in revised form 9 March 2010; accepted 25 May 2010. published online 07 June 2010.

Abstract 

Objective

To determine the effects of ritodrine and magnesium sulfate on maternal–fetal blood flows.

Study design

A total of 85 pregnant women between 26th and 36th weeks with preterm labor, and 83 healthy pregnant women were included. Patients in the study group were randomly assigned to receive either ritodrine (with the addition of verapamil) (n=46) or magnesium sulfate (n=39). Blood flow examinations on the umbilical artery (UA), middle cerebral artery (MCA), bilateral uterine arteries (Ut.A) and ductus venosus (DV) were performed before and 48h after initiating therapy.

Results

UA pulsatility index (PI) significantly differed in women receiving tocolysis compared to controls after 48h. DV PI increased in women receiving MgSO4, whereas it decreased in the ritodrine and control groups. Ut.A values did not significantly change after 48h in the groups.

In women between the 26th and 32nd weeks, UA, MCA and DV PI did not significantly change after 48h in the three groups. However, in women between the 32nd and 36th weeks UA and MCA PI significantly differed in the treatment groups compared to controls after 48h. DV PI increased in women receiving MgSO4, whereas it decreased in the ritodrine and control groups.

Conclusions

MgSO4 and ritodrine affect blood flow patterns after 48h in some maternal–fetal vessels. These effects on blood flow are particularly significant in women between 32nd and 36th weeks. The effects of both drugs on fetal and maternal Doppler flows seem similar, except the increased resistance to flow in DV in women receiving MgSO4.

Keywords: Doppler, Magnesium sulfate, Preterm, Ritodrine, Tocolysis

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☆ The authors have no connection to any of the companies or products mentioned in this article.

☆☆ Presented at the XXI European Congress of Perinatal Medicine, Istanbul, September 10–13, 2008.

PII: S0301-2115(10)00266-6

doi:10.1016/j.ejogrb.2010.05.021

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 152, Issue 1 , Pages 50-54, September 2010

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