Maternal caffeine consumption and sine causa recurrent miscarriage

Erato M. Stefanidou; Laura Caramellino; Ambra Patriarca; Guido Menato

doi:10.1016/j.ejogrb.2011.04.024

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Maternal caffeine consumption and sine causa recurrent miscarriage

Erato M. Stefanidou

Email the author Erato M. Stefanidou

Laura Caramellino

Correspondence information about the author Laura Caramellino

Email the author Laura Caramellino

Ambra Patriarca

Guido Menato

Department of Obstetrics and Gynecology, University of Turin, Sant’Anna Hospital, Via Ventimiglia 3, 10126 Turin, Italy

DOI: http://dx.doi.org/10.1016/j.ejogrb.2011.04.024

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Abstract

Objective

The objective of this study was to examine whether the risk of sine causa recurrent miscarriage is associated with caffeine consumption during the periconceptional period and early gestation after controlling for pregnancy-related symptoms.

Study design

A retrospective case–control study was conducted in the Department of Obstetrics and Gynecology, University of Turin between 2008 and 2009. Fifty-two sine causa recurrent miscarriers and 260 healthy pregnant women were assessed. Data were analyzed using SPSS 17 for Windows.

Results

Caffeine consumption during the periconceptional period and early gestation was higher in sine causa recurrent miscarriers compared to healthy pregnant women. Moreover, each caffeine intake of 100 mg/day was associated with an increased odds ratio for sine causa recurrent miscarriage of 2724 (p for trend 0.001; 95% confidence interval [CI], 2.715–2.733), after adjusting for relevant confounding covariates.

Conclusion

Caffeine intake may increase the risk of sine causa recurrent miscarriage regardless of pregnancy-related symptoms and relevant covariates (such as age and tobacco use).

Keywords:

Sine causa recurrent miscarriage, Caffeine, Pregnancy

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Maternal caffeine consumption and sine causa recurrent miscarriage

Correspondence

Correspondence

Article Info

Abstract

Objective

Study design

Results

Conclusion

Keywords:

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