European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 160, Issue 1 , Pages 1-5 , January 2012

Efficacy of auto-crosslinked hyaluronan gel for adhesion prevention in laparoscopy and hysteroscopy: a systematic review and meta-analysis of randomized controlled trials

  • Valerio Mais

      Affiliations

    • Division of Gynaecology, Obstetrics and Pathophysiology of Human Reproduction, Department of Surgery, Maternal–Fetal Medicine and Imaging, University of Cagliari, 09124 Cagliari, Italy
    • Corresponding Author InformationCorresponding author at: Division of Gynecology, Obstetrics and Pathophysiology of Human Reproduction, Department of Surgery, Maternal–Fetal Medicine and Imaging, University of Cagliari, Ospedale S. Giovanni di Dio, Via Ospedale 46, 09124 Cagliari, Italy. Tel.: +39 070652797; fax: +39 070668575.
    • ,
  • Maria G. Cirronis

      Affiliations

    • Division of Gynaecology, Obstetrics and Pathophysiology of Human Reproduction, Department of Surgery, Maternal–Fetal Medicine and Imaging, University of Cagliari, 09124 Cagliari, Italy
    • ,
  • Michele Peiretti

      Affiliations

    • Division of Gynaecology, European Institute of Oncology, 20141 Milano, Italy
    • ,
  • Giuliano Ferrucci

      Affiliations

    • Informa S.r.l., 00154 Roma, Italy
    • ,
  • Ester Cossu

      Affiliations

    • Division of Gynaecology, Obstetrics and Pathophysiology of Human Reproduction, Department of Surgery, Maternal–Fetal Medicine and Imaging, University of Cagliari, 09124 Cagliari, Italy
    • ,
  • Gian B. Melis

      Affiliations

    • Division of Gynaecology, Obstetrics and Pathophysiology of Human Reproduction, Department of Surgery, Maternal–Fetal Medicine and Imaging, University of Cagliari, 09124 Cagliari, Italy

Received 3 March 2011 ,Revised 12 July 2011 ,Accepted 31 August 2011.

References 

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  3. Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg. 2001;18:260–273
  4. Lower AM, Hawthorn RJS, Clark D, et al. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24,046 patients. Hum Reprod. 2004;19:1877–1885
  5. Deans R, Abbott J. Review of intrauterine adhesions. J Minim Invasive Gynecol. 2010;17:555–569
  6. Reijnen MM, Falk P, van Goor H, Holmdahl L. The antiadhesive agent sodium hyaluronate increases the proliferation rate of human peritoneal mesothelial cells. Fertil Steril. 2000;74:146–151
  7. Metwally M, Watson A, Lilford R, Vandekerckhove P. Fluid and pharmacological agents for adhesion prevention after gynaecological surgery. Cochrane Database Syst Rev. 2006;2:CD001298
  8. Mais V, Bracco GL, Litta P, Gargiulo T, Melis GB. Reduction of postoperative adhesions with an auto-crosslinked hyaluronan gel in gynaecological laparoscopic surgery: a blinded, controlled, randomized, multicentre study. Hum Reprod. 2006;21:1248–1254
  9. Renier D, Bellato P, Bellini D, Pavesio A, Pressato D, Borrione A. Pharmacokinetic behaviour of ACP gel, an autocrosslinked hyaluronan derivative, after intraperitoneal administration. Biomaterials. 2005;26:5368–5374
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  16. Acunzo G, Guida M, Pellicano M, et al. Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective randomized, controlled study. Hum Reprod. 2003;18:1918–1921
  17. De Iaco PA, Muzzupapa G, Bovicelli A, et al. Hyaluronan derivative gel (Hyalobarrier gel) in intrauterine adhesion (IUA) prevention after operative hysteroscopy. Ellipse. 2003;19:15–18
  18. Pellicano M, Bramante S, Cirillo D, et al. Effectiveness of autocrosslinked hyaluronic acid gel after laparoscopic myomectomy in infertile patients: a prospective, randomized, controlled study. Fertil Steril. 2003;80:441–444
  19. Guida M, Acunzo G, Di Spiezio Sardo A, et al. Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study. Hum Reprod. 2004;19:1461–1464
  20. Pellicano M, Guida M, Bramante S, et al. Reproductive outcome after autocrosslinked hyaluronic acid gel application in infertile patients who underwent laparoscopic myomectomy. Fertil Steril. 2005;83:498–500
  21. Sawada T, Nishizawa H, Nishio E, Kadowaki M. Postoperative adhesion prevention with an oxidized regenerated cellulose adhesion barrier in infertile women. J Reprod Med. 2000;45:387–389
  22. Metwally M, Gorvy D, Watson A, Li TC. Hyaluronic acid fluid agents for the prevention of adhesions after fertility-preserving gynecological surgery: a meta-analysis of randomized controlled trials. Fertil Steril. 2007;87:1139–1146

PII: S0301-2115(11)00494-5

doi: 10.1016/j.ejogrb.2011.08.002

European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume 160, Issue 1 , Pages 1-5 , January 2012

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