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Abstract
A technique was required to identify the start of the ovarian cycle in hysterectomized women. Daily observations of the excretion of pregnanediol relative to creatinine by menstruant women during the course of 15 ovulatory cycles have been used to establish (a) that the centre of the pregnanediol peak can be located from as few as two pregnanediol measurements per week and (b) that this centre precedes the start of menstruation by 7.14 ± 0.07 days (mean ± SEM). With this information the onset of menstrual bleeding in an ovulatory cycle can be predicted. Comparison of the prediction with the observation of menstrual onset in 50 cycles gave a mean deviation of 0.276 ± 0.109 days with a maximum deviation of 1.9 days. In three women observed before and after hysterectomy there was no significant change in the length of the ovarian cycle. It is concluded that this procedure provides a way of identifying the start of a new ovarian cycle in women who have no uterus. The procedure is only applicable to ovulatory cycles.
Keywords
References
- Hormonal profile of the cycle in 68 normally menstruating women.Acta Endocrinol. 1980; 94: 89-98
- Incidence of ovulation from the menarche to the menopause: observations of 622 New Zealand women.NZ Med J. 1983; 96: 645-648
- Indices of ovulation: comparison of plasma and salivary levels of progesterone and urine pregnanediol.J Endocrinol. 1984; 100: 75-80
- Incidence of ovulation in women approaching the menopause.J Biosocial Sci. 1979; 11: 39-48
- Incidence of ovulation in young women.J Biosocial Sci. 1980; 12: 345-352
- Rapid gas chromatographic assay for progesterone metabolites in urine.Clin Biochem. 1973; 6: 307-320
- The determination of creatinine by means of automatic chemical analysis.Am J Clin Pathol. 1961; 35: 83-88
- Ovarian follicular development from the onset of luteal regression in humans and sheep.in: Follicular Maturation and Ovulation. 3rd edn. International Congress Series 560. Excerpta Medica, Amsterdam1982: 1-18
- The future function and fortune of ovarian tissue which is retained in vivo after hysterectomy.Am J Obstet Gynecol. 1977; 128: 626-632
Article info
Publication history
Accepted:
September 16,
1987
Identification
Copyright
© 1988 Published by Elsevier Inc.
