Guidelines for the management of ovarian cancer during pregnancy

  • Author Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Henri Marret
    Correspondence
    Corresponding author at: Tours University Hospital, Hôpital Bretonneau, Department of Gynaecology and Obstetrics, Foetal Medicine, Medicine and Reproductive Biology, Tours 37044 cedex 1, France. Tel.: +33 47 47 47 41; fax: +33 (0)2 47 47 92 73.
    Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Affiliations
    Centre Hospitalier Regionale et Universitaire de Tours, Hôpital Bretonneau, Tours 37044 cédex 1, France
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  • Author Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Catherine Lhommé
    Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Affiliations
    Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
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  • Author Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Fabrice Lecuru
    Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Affiliations
    Hopital Européen Gorges Pompidou 20, rue Leblanc 75 Paris 15ème, France
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  • Author Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Michel Canis
    Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Affiliations
    Hotel Dieu CHU bd Léon Malfreyt, 63058 Clermont Ferrand, France
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  • Author Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Jean Lévèque
    Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Affiliations
    Centre Hospitalier Universitaire de Rennes 16 bd de Bulgarie, 35200 Rennes, France
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  • Author Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Francois Golfier
    Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Affiliations
    Centre Hospitalier Lyon Sud: Chemin du Grand Revoyet - 69495 Pierre Bénite, France
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  • Author Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Philippe Morice
    Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
    Affiliations
    Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Search for articles by this author
  • Author Footnotes
    1 On behalf of the French Working Group on Gynecological Cancers in Pregnancy SFOG (Société Française d’Oncologie Gynècologique), SFCP (Société Française de Chirurgie Pelvienne), CNGOF (Collège National des Gynécologues Obstétriciens Français).
Published:December 17, 2009DOI:https://doi.org/10.1016/j.ejogrb.2009.12.001

      Abstract

      Adnexal masses may be detected during prenatal ultrasound, and ovarian cancer may be suspected during pregnancy. Even though such masses are rarely malignant (1/10,000 to 1/50,000 pregnancies), the possibility of borderline tumour or cancer must be considered. It is a common assumption by both patients and physicians that if an ovarian cancer is diagnosed during pregnancy, treatment necessitates sacrificing the well-being of the fetus. However, in most cases, it is possible to offer appropriate treatment to the mother without placing the fetus at serious risk.
      The care of a pregnant woman with cancer involves evaluation of sometimes competing maternal and fetal risks and benefits. These recommendations attempt to balance these risks and benefits; however, they should be considered advisory and should not replace specific interdisciplinary consultation with specialists in maternal–fetal medicine, gynecologic oncology and pediatrics, as well as imaging and pathology, as needed.
      Second level ultrasound including Doppler is needed. MRI is not often necessary, and CA 125 is of low contribution. We suggest surgery be performed after 15 weeks gestation for ovarian masses which (1) persist into the second trimester, (2) are greater than 5–10 cm in diameter, or (3) have solid or mixed solid and cystic ultrasound characteristics. During the antepartum period surgical staging and debulking, unilateral salpingo-oophorectomy on the side with the tumour, peritoneal cytology and exploration are necessary. Women found to have advanced stage epithelial ovarian cancer should consider having completion of the debulking of the reproductive organs at the conclusion of the pregnancy. If chemotherapy is indicated, we recommend delaying administration, if possible, until after the delivery or at least after 20 weeks in order to minimize the potential fetal toxicity.

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