A 26-year-old primigravida woman came to the clinic for prenatal care at 12 weeks
of pregnancy. History and examination were remarkable only for mild weakness of the
muscles of facial expression and myotonia in the hand muscles. An electromyogram showed
electrical myotonia in right abductor digiti quinti, brachioradialis, and interosseal
muscles. Genetic study confirmed the diagnosis of myotonic dystrophy showing more
than 50 CTG repeats in the 19q 13.3 locus. Genetic amniocentesis otherwise ruled out
the infant to have congenital myotonic dystrophy.
Keywords
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References
- Clinical effects of myotonic dystrophy on pregnancy and the neonate.Arch. Neurol. 1976; 33: 459-465
- Myotonic dystrophy and pregnancy: a review.Obstet. Gynecol. Surv. 1986; 41: 272-278
Ehring GR, Kerschbaum HH, Eder C, et al. A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signalling, and gene expression in T lymphocytes. J Exp Med 1998;188:1593–602.
- Possible role of apamin-sensitive K+ channels in myotonic dystrophy.Muscle Nerve. 1994; 17: 1264-1270
Article info
Publication history
Accepted:
June 10,
2000
Identification
Copyright
© 2001 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
