Advertisement
Research Article| Volume 95, ISSUE 2, P202-205, April 2001

Thrombophilia and fetal growth restriction

DOI:https://doi.org/10.1016/S0301-2115(00)00491-7
Thrombophilia and fetal growth restriction
Previous ArticleThe endothelium: vascular control of haemostasis
Next ArticleClotting disorders and placental abruption: homocysteine — a new risk factor
      Since the early nineties evidence is accumulating, indicating that thrombophilia has a negative impact on pregnancy [

      Kupfermince MJ, Eldor A, Steinman N, et al. Increased frequency of genetic thrombophilia in women with complications in pregnancy. N Engl J Med 1999;341:384.

      ,
      • Greer I.A.
      Thrombosis in pregnancy: maternal and fetal issues.
      Lancet. 1999; 353: 1258-1265
      ]. Women with a thrombophilic disorder experience more often spontaneous abortion or vascular complications such as fetal growth restriction (IUGR), placental abruption, pregnancy-induced hypertension and preeclampsia [
      • Sibai B.M.
      Thrombophilias and adverse outcomes of pregnancy.
      N. Engl. J. Med. 1999; 340: 50-52
      ,
      • Lockwood C.J.
      Heritable coagulopathies in pregnancy.
      Obstet. Gynecol. Survey. 1999; 54: 754-765
      ]. Also the incidence of intra-uterine fetal death has been reported increased, presumably in conjunction with acute events such as placental infarction or thrombosis. Conversely, a thrombophilic disorder was retrieved from up to 60% of the women with a history of one (or more) of these complications [

      Kupfermince MJ, Eldor A, Steinman N, et al. Increased frequency of genetic thrombophilia in women with complications in pregnancy. N Engl J Med 1999;341:384.

      ,
      • Spaanderman M.E.A.
      • Ekhart T.H.A.
      • de Leeuw P.W.
      • Peeters L.L.H.
      Latent hemodynamic abnormalities in symptom-free women with a history of preeclampsia.
      Am. J. Obstet. Gynecol. 2000; 182: 101-107
      ,

      Dekker GA, de Vries JJP, Doelitzsch PM, et al. Underlying disorders associated with severe preeclampsia. Am J Obstet Gynecol 1995;173:1042–8.

      ,

      Van Pampus MG, Dekker GA, Wolf H, et al. High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia. Am J Obstet Gynecol 1999;180:1146–50.

      ]. These epidemiological data support an association between thrombophilia and poor pregnancy outcome. This review attempts, on the basis of the limited available research data, to develop a hypothesis about the mechanism by which thrombophilia interferes with placentation and normal maternal adaptation to pregnancy, with emphasis on the development of IUGR.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Obstetrics and Gynecology and Reproductive Biology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

      1. Kupfermince MJ, Eldor A, Steinman N, et al. Increased frequency of genetic thrombophilia in women with complications in pregnancy. N Engl J Med 1999;341:384.

        View in Article
        • Greer I.A.
        Thrombosis in pregnancy: maternal and fetal issues.
        Lancet. 1999; 353: 1258-1265
        View in Article
        • Sibai B.M.
        Thrombophilias and adverse outcomes of pregnancy.
        N. Engl. J. Med. 1999; 340: 50-52
        View in Article
        • Spaanderman M.E.A.
        • Ekhart T.H.A.
        • de Leeuw P.W.
        • Peeters L.L.H.
        Latent hemodynamic abnormalities in symptom-free women with a history of preeclampsia.
        Am. J. Obstet. Gynecol. 2000; 182: 101-107
        View in Article

      5. Dekker GA, de Vries JJP, Doelitzsch PM, et al. Underlying disorders associated with severe preeclampsia. Am J Obstet Gynecol 1995;173:1042–8.

        View in Article

      6. Van Pampus MG, Dekker GA, Wolf H, et al. High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia. Am J Obstet Gynecol 1999;180:1146–50.

        View in Article
        • Bombell T.
        • Mueller M.
        • Haeberli A.
        Anticoagulant properties of the vascular endothelium.
        Thromb. Haemost. 1997; 77: 408-423
        View in Article
        • Bonnar J.
        • Daly L.
        • Sheppard B.L.
        Changes in the fibrinolytic system during pregnancy.
        Seminars Thromb. Hemost. 1990; 16: 221-229
        View in Article

      9. Clark P, Brennand J, Conkie JA, et al. Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy. Thromb Haemost 1998;79:1166–70.

        View in Article
        • Lockwood C.J.
        Heritable coagulopathies in pregnancy.
        Obstet. Gynecol. Survey. 1999; 54: 754-765
        View in Article
        • Rai R.
        • Regan L.
        Obstetrical complications of antiphospholipid antibodies.
        Curr. Opin. Obstet. Gynecol. 1997; 9: 387-390
        View in Article
        • Eliyahu S.
        • Shalev E.
        Essential thrombocythemia during pregnancy.
        Obstet. Gynecol. Survey. 1997; 52: 243-247
        View in Article

      13. Genbacev O, Joslin R, Damsky CH, et al. Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia. J Clin Invest 1996;97:540–50.

        View in Article
        • Jaffe R.
        • Jauniaux E.
        • Hustin J.
        Maternal circulation in the first-trimester human placenta — myth or reality?.
        Am. J. Obstet. Gynecol. 1997; 176: 695-705
        View in Article

      15. Caniggia I, Winter J, Lye SJ, Post M. Oxygen and placental development during the first trimester: implications for the pathophysiology of preeclampsia. Placenta 2000;(Suppl A):S25–S30.

        View in Article
        • Sheppard B.L.
        • Bonnar J.
        Uteroplacental hemostasis in intrauterine fetal growth retardation.
        Seminars Thromb. Hemost. 1999; 25: 443-446
        View in Article

      17. Myatt L, Kossenjans W, Sahay R, et al. Oxidative stress causes vascular dysfunction in the placenta. J Matern Fetal Med 2000;9:79–82.

        View in Article
        • Fitzpatrick T.E.
        • Graham C.H.
        Stimulation of plasminogen activator inhibitor-1 expression in immortalized human trophoblast cells cultured under low levels of oxygen.
        Exp. Cell Res. 1998; 245: 155-162
        View in Article
        • Kruithof E.K.O.
        • Baker M.S.
        • Bunn C.L.
        Biological and clinical aspects of plasminogen activator inhibitor type-2.
        Blood. 1995; 86: 4007-4024
        View in Article
        • Kingdom J.C.
        • Kaufman P.
        Oxygen and placental vascular development.
        Adv. Exp. Med. Biol. 1999; 474: 259-275
        View in Article

      Article info

      Identification

      DOI: https://doi.org/10.1016/S0301-2115(00)00491-7

      Copyright

      © 2001 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX