Increase in APC-resistance (APC-r), also in the absence of factor V Leiden is a risk factor for venous thrombosis. There are several ways to measure the sensitivity of a plasma to the anticoagulant action of APC. One is the classical aPTT based test, another is the thromboplastin dependent thrombin generation in defibrinated plasma. Both tests are equally sensitive to the presence of factor V Leiden, but differ largely in their sensitivity to acquired conditions, such as oral contraceptive use and pregnancy. In the present study the influence of factor V Leiden, oral contraceptive use (also second versus third generation oral contraceptives) and pregnancy in women with or without a history of pre-eclampsia on the APC-r levels were determined.
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© 2001 Published by Elsevier Inc.