Abstract
The activities of some glycosaminoglycan-degrading enzymes in uterine leiomyomas.
Both normal human myometrium and uterine leiomyoma contain several glycosaminoglycans
(GAGs). In contrast to many normal and tumour tissues the amount of hyaluronic acid
(HA) is very low and the proportional amount of sulphated glycosaminoglycans is distinctly
higher. We compared the activity of GAG-degrading enzymes in normal myometrium and
in uterine leiomyomas. Growth of uterine leiomyomas results in significant reduction
in the activities of neutral endoglycosidases degrading most of the sulphated glycosaminoglycans.
The activities of acid endoglycosidases also decreased (with the exception of chondroitin-6-sulphate).
Thus, the differentiated activity of glycosidases degrading glycosaminoglycans can
be a factor modifying the quantity of GAGs.
Keywords
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śniakach macicy.Article info
Publication history
Accepted:
October 18,
2002
Received in revised form:
October 10,
2002
Received:
February 28,
2002
Identification
Copyright
© 2003 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
