Abstract
Objective: To examine the association between individual exposures due to occupation, environment
and lifestyle on sperm count, we conducted a case-control study among 92 fertile and
73 sub-fertile Caucasian males. Study Design: Data from questionnaires were analysed using simple univariate and multivariate
logistic regression models. Results: At risk for oligozoospermia are men exposed to pesticides (odds ratio (OR) 8.4;
95% confidence interval (CI) 1.3–52.1), welding (OR 2.8; CI 0.9–8.7), antibiotic use
(OR 15.4; CI 1.4–163), a history of mumps (OR 2.9; CI 1.3–6.7), gastrointestinal complaints
(OR 6.2; CI 1.4–26.8), decreased intake of fruits (OR 2.3; CI 1.0–5.1), vegetables
(OR 1.9; CI 0.7–5.0), or with female fertility disorders in their families (OR 8.4;
CI 1.7–41.9). Unlike other studies, no associations were observed between oligozoospermia
and exposure to paint or heat. Conclusion: This study suggests new risk factors oligozoospermia in man and confirms previously
reported results from others.
Keywords
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References
- Testicular function in DBCP exposed pesticide workers.J. Occup. Med. 1979; 21: 161-166
- Effects of exposure to ethylene glycol ethers on shipyard painters. II. Male reproduction.Am. J. Ind. Med. 1988; 14: 509-526
- Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract.Lancet. 1993; 341: 1392-1395
- Semen quality in welders exposed to radiant heat.Br. J. Ind. Med. 1992; 49: 5-10
- Stainless steel welding and semen quality.Reprod. Toxicol. 1988; 2: 213-215
- Semen analysis in alcohol dependence syndrome.Andrologia. 1985; 17: 558-563
- Cigarette smoking and semen quality.Fertil. Steril. 1996; 65: 835-842
- Occupational heat exposure and male fertility: a review.Hum. Reprod. 1998; 13: 2122-2125
- Changes in seminal quality following oral zinc therapy.Andrologia. 1988; 20: 21-22
- Vitamin D is necessary for reproductive functions of the male rat.J. Nutr. 1989; 119: 741-744
- Sperm quality and ascorbic acid concentration in rainbow trout semen are affected by dietary vitamin C: an across-season study.Biol. Reprod. 1995; 52: 982-988
- Selenium-vitamin E supplementation in infertile men. Effects on semen parameters and micronutrient levels and distribution.Biol. Trace Elem. Res. 1996; 53: 65-83
- Antibiotics: potential hazards to male fertility.Fertil. Steril. 1991; 55: 235-242
- Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility.Int. J. Androl. 1993; 16: 1-13
Forman R, Gilmour-White S, Forman S. Antibiotics. In: Forman R, Gilmour-White S, Forman N, editors. Drug-induced infertility and sexual dysfunction. Cambridge: Cambridge University Press; 1996. p. 85–91.
- Coeliac disease and reproductive disorders: a neglected association.Eur. J. Obstet. Gynecol. Reprod. Biol. 2001; 96: 146-149
- Chromosome studies in 1792 males prior to intra-cytoplasmic sperm injection: The Dutch experience.Eur. J. Hum. Genet. 1998; 6: 194-200
- Effects of folic acid and zinc sulfate on male factor sub-fertility: a double-blind, randomized, placebo-controlled trial.Fertil. Steril. 2002; 77: 491-498
World Health Organization. Laboratory Manual for the examination of human semen and semen-cervical mucus interaction. Cambridge: Cambridge University Press; 1992.
- Intra-individual variability and redundancy of semen parameters.Epidemiology. 1997; 8: 99-103
- Effects of pesticide exposure on time to pregnancy. Results of a multicenter study in France and Denmark.Am. J. Epidemiol. 1999; 150: 157-163
- The effect of antibiotics on bacteria in semen and on motility and fertilizing ability of chicken spermatozoa.Am. J. Vet. Res. 1958; 19: 945-949
- Influence of antibiotics on spermatogenesis.J. Urol. 1974; 112: 348-349
- Side-effects of salazopyrin on male fertility.Eur. J. Obstet. Gynecol. Reprod. Biol. 1984; 18: 361-364
- Coeliac infertility—folic acid therapy.Lancet. 1970; 1: 4-12
Love AHG, Elmes M, Golden MK, et al. Zinc deficiency and coeliac disease. In: McNicoll B, McCarthy CF, Fotterll PF, editors. Perspectives in coeliac disease. Lancaster: MTP Press; 1978. p. 335–342.
- Male gonadal function in coeliac disease: sex hormones.Gut. 1983; 24: 127-135
Rostami K, Kerckhaert J, Werre JM, et al. High prevalence of coeliac disease in apparently healthy blood donor suggests a high prevalence of undiagnosed coeliac disease in the Dutch population. Scand J Gastroenterol 1999;34:276–9.
- Male factor sub-fertility: possible causes and the impact of nutritional factors.Fertil. Steril. 2000; 73: 435-442
- Semen quality in papaya workers with long-term exposure to ethylene dibromide.Br. J. Ind. Med. 1987; 44: 317-326
- Time to pregnancy and occupational exposure to pesticides in fruit growers in The Netherlands.Occup. Environ. Med. 1994; 51: 693-699
- Pesticide exposure and decreased fertilisation rates in vitro.Lancet. 1999; 354: 484-485
- Occupational hazards to male fecundity.Reprod. Med. Rev. 1995; 4: 59-73
- The effect of pesticide exposure on time to pregnancy.Epidemiology. 1999; 10: 112-117
- Occupational hazards for the male reproductive system.Crit. Rev. Toxicol. 1996; 26: 261-307
- Effects of occupational solvent exposure on fertility.Scand. J. Work Environ. Health. 1999; 25: 44-46
- Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case-control study.Br. J. Ind. Med. 1993; 50: 71-78
- Testicular heating and its possible contributions to male infertility: a review.Int. J. Androl. 1995; 18: 169-184
- External quality control in the andrology laboratory: an experimental multicenter trial.Fertil. Steril. 1990; 54: 308-314
Article Info
Publication History
Accepted:
February 10,
2003
Received in revised form:
December 27,
2002
Received:
August 14,
2002
Identification
Copyright
© 2003 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
