Abstract
Objective: To compare the efficacy and safety of misoprostol (prostaglandin E1 (PGE1)) with dinoprostone (prostaglandin E2 (PGE2)) for third trimester cervical ripening and labor induction. Study design: Patients requiring induction of labor were randomly assigned to receive either 50 μg of intravaginal misoprostol every 4 h or 0.5 mg of intracervical dinoprostone gel every 6 h. Eligibility criteria included gestation = 36 weeks. Primary outcome was the time
interval from induction to delivery; secondary outcomes were mode of delivery, perinatal
outcome, and interpretation of cardiotocogram (CTG) records. Results: Two hundred women were randomly enrolled to receive either misoprostol (n=100) or dinoprostone (n=100). Time induction-to-delivery at 12, 24 and 48 h and the need for oxytocin were reduced with misoprostol (P<0.05). Pathological CTG tracing according to FIGO and Melchior scores were more frequent
in the misoprostol-treated group (P<0.001). Conclusion: Misoprostol shortened the induction-to-delivery interval, but is associated with
a higher incidence of abnormal CTG than prostaglandin E2.
Keywords
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Article info
Publication history
Accepted:
January 15,
2004
Received:
May 25,
2003
Identification
Copyright
© 2004 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
