Research Article| Volume 116, ISSUE 1, P54-57, September 10, 2004

A trial of a new regimen with clomiphene citrate administration to reduce the antiestrogenic effects on reproductive end organs


      Objective: To determine the endocrinological and clinical outcomes of a 3-day clomiphene citrate (CC) regimen and compare it with the classical 5-day clomiphene citrate regimen. Study design: 59 patients, diagnosed with Class II ovulatory deficiency according to the criteria defined by WHO, were randomized into two groups. Patients in Group I received 50 mg per day of CC for 3 days starting on the first day of the cycle during 72 cycles. Group II received 50 mg per day of CC for 5 days starting on the fifth day during 64 cycles. Result(s): The ovulation rate was significantly higher in Group II (78.11%) compared to Group I (63.88%) (P<0.05). However, the implantation rate was higher in Group I than Group II. Conclusion: We observed that starting CC on the first day of the cycle for 3 days would lead to higher implantation rates compared to the classical 5-day CC therapy.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


        • Biljan M.M
        • Mahutte N.G
        • Tulandi T
        • Lin Tan S
        Prospective randomized double-blind trial of the correlation between time of administration and antiestrojenic effects of clomiphene citrate on reproductive end organs.
        Fertil Steril. 1997; 71: 633-638
      1. World Health Organization Scientific Group Report. Consultation on the diagnosis and treatment of endocrine forms of female infertility. World Health Organization Technical Report Series 514. Genava: World Health Organization; 1976.

        • Adashi E.Y
        Clomiphene citrate: mechanism(s) and site(s) of action—a hypothesis revisited.
        Fertil Steril. 1984; 42: 331-344
        • Marrs P.P
        • Vargyas J.M
        • Shangold G.M
        • Yee B
        The effect of time initiation of clomiphene citrate on multiple follicle development for human in vitro fertilization and embryo replacement procedures.
        Fertil Steril. 1984; 41: 682-685
        • Drake T.S
        • Tredway D.R
        • Buchanan G.C
        Continued clinical experience with an increasing dosage regimen of clomiphene citrate administration.
        Fertil Steril. 1978; 30: 274-277
        • Gysler M
        • March C.M
        • Mishell Jr., D.R
        • Bailey E.J
        A decade’s experience with an individualized clomiphene treatment regimen including its effect on the postcoital test.
        Fertil Steril. 1982; 37: 161-167
        • Whitelaw M.J
        • Grans L.R
        • Stamm W.J
        Clomiphene citrate: it’s uses and observations on it’s probable action.
        Am. J. Obstet. Gynecol. 1964; 90: 335-363
        • Van Campenhout J
        • Simard R
        • Leduc B
        Antiestrogenic effect of clomiphene in the human being.
        Fertil Steril. 1968; 19: 700-706
        • Markiewicz L
        • Laufer N
        • Gurpide E
        In vitro effects of clomiphene citrate on human endometrium.
        Fertil Steril. 1988; 50: 772-777
        • Nelson L.M
        • Hershlag A
        • Kurl R.S
        • Hall J.L
        • Stillman R.J
        Clomiphen citrate directly impairs endometrial receptivity in the mouse.
        Fertil Steril. 1990; 53: 727-734
        • Schreiber E
        • Johnson J.E
        • Plotz E.J
        • Weiner M
        Studies with Math Eq labelled clomiphene citrate.
        Clin Res. 1966; 14: 287-290
        • Wu C.H
        Plasma hormones in clomiphene citrate therapy.
        Obstet Gynecol. 1977; 49: 443-448
        • Mikkelson T.J
        • Kroboth P.D
        • Cameron W.J
        • Dittert L.W
        • Chungi V
        • Manberg P.J
        Single-dose pharmacokinetics of clomiphene citrate in normal volunteers.
        Fertil Steril. 1986; 46: 392-396
        • Göl K
        • Gürsoy R
        • Karabacak O
        • Yildirim M
        The effects of 3-day clomiphene citrate treatment on endocrine and ovulatory responses.
        Gynecol Endocrinol. 1966; 10: 171-176
        • Greenblatt R.B
        • Barfield W.E
        • Jungck E.C
        • Ray A.W
        Induction of ovulation with MRL/41.
        J. Am Med. Assoc. 1961; 178: 101-104
        • Pildes R.B
        Induction of ovulation with clomiphene.
        Am. J. Obstet. Gynecol. 1965; 91: 466-479
        • Marinko M
        • Biljan M.R.C.O.G
        • Mahutte N.G
        • Tulandi T
        • Seang Lin Tan F.R.C.O.G
        Propective randomized double-blind trial of the correlation between time of administration and antiestrogenic effects of clomiphene citrate on reproductive end organs.
        Fertil Smentteril. 1997; 71: 633-638
        • Zaidi J
        • Pittrof R
        • Shaker A
        • Kyei-Mensah A
        • Campbell S
        • Tan S.L
        Assessment of uterine artery blood flow on the day of human chorionic gonadotropin administration by transvaginal color Doppler ultrasound in an in vitro fertilization program.
        Fertil Steril. 1996; 65: 377-381
        • Fujii S
        • Fukui A
        • Fukushi Y
        • Kagiya A
        • Sato S
        • Saito Y
        The effects of clomiphene citrate on normally ovulatory women.
        Fertil Steril. 1997; 68: 997-999
      2. World Health Organization. Laboratory manual for the examination of human semen and semen-cervical mucus interaction. 2nd ed. Cambridge: The Press Syndicate of the University of Cambridge; 1987. p. 3–10.