Objective: To elucidate whether endometriosis can be diagnosed clinically by assessing the differences between serum CA125 levels during menstruation and during the rest of the menstrual cycle. Methods: The study was performed in 28 patients who underwent laparoscopy to check for pelvic causes of infertility. Patients with endometriosis were selected as the study group, and patients with normal laparoscopic findings functioned as the control group. Blood specimens were taken for CA125 determination during menstruation and during the rest of the menstrual cycle. Mean serum CA125 concentrations were compared by the two-sample t-test for between-group comparisons and the paired t-test for within-group comparisons. The receiver operating characteristic curve was applied to assess the usefulness of CA125 level changes during the menstrual cycle in the clinical diagnosis of endometriosis. Results: The mean CA125 concentrations of healthy women during menstruation and during the rest of the menstrual cycle were 12.2 and 10 U ml−1, respectively. In this group, the mean CA125 concentration was an average of 22% higher during menstruation than during the rest of the menstrual cycle (P<0.001). The patients with endometriosis showed a similar pattern to that of normal women, but the levels differed by 198.3% in these patients (P<0.001). Mean CA125 concentrations of these patients during menstruation and in the rest of the cycle were 35.8 and 12 U ml−1, respectively. The mean CA125 concentration during menstruation was significantly higher in patients with endometriosis than in normal women (P<0.001), but CA125 concentrations at other points in the menstrual cycle were found to be similar in both groups (P>0.05). ROC curve analyses set a cutoff of 83% (percentage increment of CA125 level during menstruation compared with that on days without menstrual bleeding), which gives a sensitivity of 93% and specificity of 92%, with a corresponding likelihood ratio of 11.3. Conclusions: It may be possible to diagnose endometriosis clinically by assessment of the differences in CA125 level during menstruation as against the remainder of the menstrual cycle.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to European Journal of Obstetrics and Gynecology and Reproductive Biology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Tumor markers in endometriosis.Int J Gynaecol Obstet. 1999; 66: 19-22
- The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis.Fertil Steril. 1998; 70: 1101-1108
- Serum and peritoneal CA-125 levels as diagnostic test for endometriosis.Eur J Obstet Gynecol Reprod Biol. 1996; 66: 41-43
- Endometriosis and pelvic pain: relation to disease stage and localization.Fertil Steril. 1995; 65: 299-304
- Evaluation and management of women with endometriosis.Obstet Gynecol. 2003; 102: 397-408
- Magnetic resonance imaging characteristics of deep endometriosis.Hum Reprod. 1999; 14: 1080-1086
- Serum CA125 levels before, during and after treatment for endometriosis.Int J Obstet Gynecol. 1995; 50: 269-273
- Serum CA125 levels do not depend on ovarian steroidogenesis.Fertil Steril. 1990; 54: 415-418
- Tumor marker CA125 in tissues of the female reproductive tract and in serum during the normal menstrual cycle.Fertil Steril. 1993; 59: 1028-1035
- Elevated levels of CA125 in serum of patients’ suffering from ovarian hyperstimulation syndrome.Fertil Steril. 1987; 48: 675-678
- Drastic elevation of serum CA125, CA72-4 and CA19-9 levels during menses in a patient with probable endometriosis.Eur J Obstet Gynecol Reprod Biol. 1998; 78: 79-81
- The prognosis for live birth among untreated infertile couples.Fertil Steril. 1995; 64: 22-28
Accepted: February 23, 2004
Received in revised form: February 7, 2004
Received: August 8, 2003
© 2004 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.