To determine an appropriate cutoff value to differentiate physiologic and pathologic birth weight discordance, to determine the prevalence of birth weight discordance ≥25% among twin pregnancies in different sub-populations, and to examine its clinical significance.
Historical cohort study of 147,262 twin sets registered in the United States between 1995 and 1997.
The prevalence of birth weight discordance ≥25% among twin pregnancies was 8.6%. The prevalence of birth weight discordance ≥25% was significantly decreased with increasing total twin birth weight deciles, was more frequently found in twins with discordant gender (9.1%) than in those twins with concordant gender (8.3%) and in mothers whose age was 30 years or older (9.1%) than those of younger mothers (8.1%). Birth weight discordance ≥25% was associated with earlier gestational age at delivery (35.0 weeks versus 36.0 weeks) and higher neonatal mortality (5.4% versus 2.3%) as compared to twins with lower birth weight discordance.
The prevalence of birth weight discordance ≥25% among twin pregnancies was 8.6%, which is associated with lower gestational age at delivery and higher neonatal mortality rates, and may represent a pathologic process.
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Accepted: October 11, 2004
Received in revised form: September 9, 2004
Received: June 25, 2004
© 2004 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.