Comment on: “Campagne DM, Fact: antidepressants and anxiolytics are not safe during pregnancy” Eur J Obstet Gynecol Reprod Biol 2007 Dec;135(2):145–8

      We are writing in response to a paper recently published in your journal: “Campagne DM. Fact: Antidepressants and anxiolytics are not safe during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2007 Dec;135(2):145–8” [
      • Campagne D.M.
      Fact: antidepressants and anxiolytics are not safe during pregnancy.
      ]. We have many concerns with this piece, starting with the title, which is incorrect as this is definitely not a review, it is an editorial reflecting the author's personal views. A review is a systematic search of the literature, enabling the author to produce the best evidence-based information, to assist clinicians in treating their patients. His concern over the statement that I made, as well as other authors,“the body of evidence in the literature to date, suggests that psychotropic drugs as a group are relatively safe to take during pregnancy” (which is incorrectly cited) [
      • Einarson A.
      The safety of psychtopic drugs in pregnancy.
      ] is unwarranted and may cause harm to women who require these medications in pregnancy, as they may be afraid to take medications for even a severe depression, which the author does acknowledge is sometimes necessary.
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        Fact: antidepressants and anxiolytics are not safe during pregnancy.
        Eur J Obstet Gynecol Reprod Biol. 2007; 135: 145-148
        • Einarson A.
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        Problems with maternal antidepressant treatment and neonatal outcomes study.
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        SSRIs and birth defects.
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        Selective serotonin reuptake inhibitor use in pregnancy and fetal outcomes.
        American Psychiatric Association Meeting, San Diego, California, USA2007
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      Linked Article

      • Author's response: Antidepressants and anxiolytics in pregnancy: The facts stand
        European Journal of Obstetrics and Gynecology and Reproductive BiologyVol. 171Issue 2
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          The reaction of Nurse Einarson and colleagues helps us to get the problem of antidepressants and anxiolytics use during pregnancy under closer scientific and ethical scrutiny. She apparently is a staunch defender of the use of SSRIs and similar medications and, with funds from their manufacturers, has participated in studies of the effects of possibly teratogenic antidepressants on pregnant women. None of these studies considered non-pharmacologic ways to treat depression or anxiety. Indeed, these studies found that malformations occurred twice or three times as often in the SSRI or venlafaxine groups compared to the non-teratogenic group.
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