We read with interest the article of Pasquier et al. “Neonatal outcomes after elective delivery management of preterm premature rupture of the membranes before 34 weeks’ gestation (DOMINOS study)” in which they presented the result of a multicenter prospective study of women with pPROM between 241/7 and 336/7 weeks’ gestation (weeks). This study shows after logistic regression that elective delivery (OR 0.41, 95%CI: 0.19–0.87, P = 0.02) is associated with decreased neonatal morbidity. This conclusion suggests that elective delivery may be a better choice than expectant management before 34 weeks. We have however, some concerns about the methodology of the study and the factors introduced in the logistic regression that led to this conclusion.
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Published online: June 19, 2009
Received: March 9, 2009
© 2009 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.