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Study of fetal tracheal fluid velocities using Doppler ultrasound

  • Gilles Grangé
    Correspondence
    Corresponding author at: Maternité Port Royal 123, Bd de Port Royal, 75014 Paris, France. Tel.: +33 1 58 41 20 46; fax: +33 1 58 41 14 32.
    Affiliations
    Maternité Port-Royal, Groupe Hospitalier Cochin Saint Vincent De Paul, APHP, Université Paris Descartes, Fondation PremUp, Paris, France
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  • Céline Bernabé-Dupont
    Affiliations
    Maternité Port-Royal, Groupe Hospitalier Cochin Saint Vincent De Paul, APHP, Université Paris Descartes, Fondation PremUp, Paris, France
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  • Dominique Cabrol
    Affiliations
    Maternité Port-Royal, Groupe Hospitalier Cochin Saint Vincent De Paul, APHP, Université Paris Descartes, Fondation PremUp, Paris, France
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Published:November 09, 2009DOI:https://doi.org/10.1016/j.ejogrb.2009.10.020

      Abstract

      Objective

      To characterize tracheal fluid flow during fetal breathing movements by Doppler ultrasound.

      Study design

      To use pulsed Doppler to measure flow velocity during inspiration and expiration in a cross-sectional study of 15 normal fetuses and determine the correlation, if any, between flow velocity and gestational age.

      Results

      Cyclic respiratory profiles – both regular and irregular – were observed. Intratracheal flow velocity was very elevated during inspiration, ranging from 10 to 80 cm/s and from 5 to 20 cm/s during expiration.

      Conclusion

      This technique enables the noninvasive semiquantitative evaluation of fetal breathing movements. This Doppler application opens the field for future studies to characterize the extent of pulmonary hypoplasia.

      Keywords

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      References

        • Dawes G.S.
        • Fox H.E.
        • Leduc B.M.
        • Liggins G.C.
        • Richards R.T.
        Respiratory movements and rapid eye movement sleep in the fetal lamb.
        J Physiol. 1972; 220: 119-143
        • Brace R.A.
        Physiology of amniotic fluid volume regulation.
        Clin Obstet Gynecol. 1997; 40: 280-289
        • Badalian S.
        • Fox H.E.
        • Zimmer E.Z.
        • Fifer W.P.
        • Stark R.I.
        Patterns of perinasal fluid flow and contractions of the diaphragm in the human fetus.
        Ultrasound Obstet Gynecol. 1996; 8: 109-113
        • Chiba Y.
        • Utsu M.
        • Kanzaki T.
        • Hasegawa T.
        Changes in venous flow and intra-tracheal flow in fetal breathing movements.
        Ultrasound Med Biol. 1985; 11: 43-49
        • Isaacson G.
        • Birnholz J.C.
        Ann Otol Rhinol Laryngol. 1991; 100: 743-747
        • Kalache K.D.
        • Franz M.
        • Chaoui R.
        • Bollmann R.
        Ultrasound measurements of the diameter of the fetal trachea, larynx and pharynx throughout gestation and applicability to prenatal diagnosis of obstructive anomalies of the upper respiratory-digestive tract.
        Prenat Diagn. 1999; 19: 211-218
        • Haddad B.
        • Fulla Y.
        • Genest F.
        • Richard B.
        • Cabrol D.
        Respiration of amniotic fluid in near-term foetal rabbit.
        Eur J Obstet Gynecol Reprod Biol. 1995; 62: 247-250
        • Galan H.L.
        • Tennant L.B.
        • Marsh D.R.
        • Creasy R.K.
        Paralysis of the preterm rabbit fetus inhibits the pulmonary uptake of intraamniotic iron dextran.
        Am J Obstet Gynecol. 1997; 177: 42-49
        • Pollack J.A.
        • Moise Jr., K.J.
        • Tyson W.R.
        • Galan H.L.
        The role of fetal breathing motions compared with gasping motions in pulmonary airway uptake of intraamniotic iron dextran.
        Am J Obstet Gynecol. 2003; 189: 958-962
        • Kalache K.D.
        • Chaoui R.
        • Marcks B.
        • et al.
        Differentiation between human fetal breathing patterns by investigation of breathing-related tracheal fluid flow velocity using Doppler sonography.
        Prenat Diagn. 2000; 20: 45-50
        • Doné E.
        • Gucciardo L.
        • Van Mieghem T.
        • et al.
        Prenatal diagnosis, prediction of outcome and in utero therapy of isolated congenital diaphragmatic hernia.
        Prenat Diagn. 2008; 28: 581-591
        • Bernabé-Dupont C.
        • Grangé G.
        • Cabrol D.
        Semiquantitative study of tracheal fluid flow in a fetus with pulmonary hypoplasia: a possible prognostic factor?.
        Ultrasound Obstet Gynecol. 2008; 32: 715-716
        • Kalache K.D.
        • Chaoui R.
        • Hartung J.
        • Wernecke K.D.
        • Bollmann R.
        Doppler assessment of tracheal fluid flow during fetal breathing movements in cases of congenital diaphragmatic hernia.
        Ultrasound Obstet Gynecol. 1998; 12: 27-32
        • Kalache K.D.
        • Chaoui R.
        • Marks B.
        • Wauer R.
        • Bollmann R.
        Does fetal tracheal fluid flow during fetal breathing movements change before the onset of labour.
        BJOG. 2002; 109: 514-519