Effect of palmitoylethanolamide–polydatin combination on chronic pelvic pain associated with endometriosis: Preliminary observations

  • Ugo Indraccolo
    Corresponding author at: Department of Surgical Sciences, Institute of Obstetrics and Gynaecology, University of Foggia, Via Montagnano 16, 62032 Camerino (MC), Italy. Tel.: +39 328 6180677 (mobile); fax: +39 0737 636668.
    Department of Surgical Sciences, Institute of Obstetrics and Gynaecology, University of Foggia. Via Pinto, 71100 Foggia, Italy

    Obstetrics and Gynaecology Unit, ULSS 17 – Veneto, Italy
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  • Fabrizio Barbieri
    Obstetrics and Gynaecology Unit, ULSS 17 – Veneto, Italy
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Published:February 11, 2010DOI:



      Endometriosis is a chronic oestrogen-dependent gynaecological disorder, the most common symptom of which is pain. Inflammation can be considered one of the major causes of pain in endometriosis. In particular, degranulating mast cells have been found in significantly greater quantities in endometriotic lesions than in unaffected tissues. The increase in activated and degranulating mast cells is closely associated with nerve structures in painful endometriotic lesions. These observations indicate that inflammation due to mast cells may contribute to the development of pain and hyperalgesia in endometriosis. Controlling mast-cell activation may therefore relieve the pain associated with endometriotic lesions.

      Study design

      Four patients presenting an endometriosis-related pain intensity ≥5 (visual analogue scale for pain, or VAS) were enrolled and monitored during 3 months of the following treatment: oral palmitoylethanolamide 400 mg and polydatin 40 mg, twice daily for 90 days. Deep dyspareunia, dyschezia, dysuria, dysmenorrhoea and analgesic drug use during the 3-month follow-up period were also monitored, with the aim of demonstrating a reliable reduction in chronic pelvic pain.


      The preliminary results indicate that all patients enrolled experienced pain relief as early as 1 month after starting treatment. Furthermore, a reduction in the analgesic drugs usually employed for pain control was observed in all subjects treated. Additionally, some improvements in endometriotic lesions seemed to be demonstrated by imaging.


      The palmitoylethanolamide–polydatin combination seems to be very useful in controlling chronic pelvic pain associated with endometriosis. As a result of these findings we have initiated a multi-centre pilot study to verify the effectiveness of this treatment in controlling the chronic pelvic pain associated with endometriosis.


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