Abstract
The purpose of this article is to create the first complete review concerning the
role of calprotectin, a calcium- and zinc-binding protein of the S100/calgranulins
family, in obstetrics and gynecology. A Medline search was conducted between 6 and
8 June 2009 using the term calprotectin and its synonyms combined with the following
ones: calprotectin, obstetrics and gynecology, breast cancer, ovarian cancer, endometrial
cancer, cervical cancer, menstrual cycle, pregnancy, fetal implantation, labor, intra-amniotic
inflammation, preeclampsia, HELLP syndrome, Rh(−) incompatibility.
We found 46 studies which referred to obstetrics and gynecology. We excluded 11 studies
which referred to obstetrics and gynecology but did not include enough information
about calprotectin, and another two which referred to calprotectin but were not related
to subjects of obstetrics and gynecology. Thus, we ended up with 33 studies which
contained sufficient information to extract data for this review. All the articles
were written in English. It was found that calprotectin is associated with many physiologic
and pathologic processes in obstetrics and gynecology, such as: breast cancer, ovarian
cancer, endometrial cancer, cervical cancer, cervical and vaginal physiology, menstrual
cycle, pregnancy and labor. The role of calprotectin in these conditions is significant.
In conclusion, the role of calprotectin seems to be important in several issues of
obstetrics and gynecology. For example, calprotectin could be used as a diagnostic,
prognostic or metastatic marker in several types of cancer, as a marker of inflammation
and as a pharmaceutical target in many conditions. Further studies must be conducted
to elucidate this role.
Keywords
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Article info
Publication history
Published online: March 25, 2010
Accepted:
March 10,
2010
Received in revised form:
February 27,
2010
Received:
August 21,
2009
Identification
Copyright
© 2010 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
