Abstract
Objective
This study aims to evaluate the effect of raloxifene on the expression of human telomerase
reverse transcriptase (hTERT) in invasive ductal breast carcinoma of postmenopausal
women.
Study design
This study included 20 postmenopausal women with invasive, stage II, estrogen receptor-positive
ductal carcinoma diagnosed by incisional biopsy, who received 60 mg of raloxifene orally for 28 days prior to definitive surgery. On the 29th day of
treatment, definitive surgery was performed and a second tumor sample was taken for
analysis. The catalytic subunit of telomerase (hTERT) was evaluated semiquantitatively
by immunohistochemistry in the tumor samples obtained prior to and following raloxifene
use and the results were analyzed using the McNemar test (p < 0.05).
Results
The samples of 17 patients (85%) were classified as positive for telomerase expression
prior to raloxifene treatment, while only 6 (30%) remained positive following raloxifene
treatment (p < 0.0026).
Conclusion
In the present study, raloxifene significantly reduced the expression of hTERT in
estrogen receptor-positive breast tumors from postmenopausal women.
Keywords
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Article info
Publication history
Published online: June 27, 2011
Accepted:
June 9,
2011
Received in revised form:
April 28,
2011
Received:
February 3,
2011
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
